Name | Maltolate |
CAS number | 108560-70-9 |
Description | maltolate is a coordination complex with the CAS Registry Number 108560-70-9. This complex is formed from, a group IIIa metal, and three maltol ligands, which are organic molecules derived from the natural compound 3-hydroxy-2-methyl-4-pyrone. |
Structural formula |  |
Molecular Formula | C18H9GaO15 |
Molecular Weight | 534.97 g/mol |
Appearance | White powder |
Quality Standard | 99% |
Storage Condition | Cool dry place( away from the light) |
Shelf Life | >2 years if stored properly |
Sample package | Aluminium foil bag |
Commercial package | Aluminium Tin, Fiber drum |
Origin | China |
maltolate is a coordination complex with the CAS Registry Number 108560-70-9. This complex is formed from gallium, a group IIIa metal, and three maltol ligands, which are organic molecules derived from the natural compound 3-hydroxy-2-methyl-4-pyrone. The resulting structure is a neutral, highly lipid-soluble complex that is notably stable under physiological conditions, allowing for efficient absorption and bioavailability.
The primary mechanism of action for maltolate is believed to be its ability to disrupt cellular iron metabolism. Due to its chemical similarity to ferric iron (Fe³⁺), can be mistaken for iron by cellular uptake systems and incorporated into iron-dependent proteins. Most significantly, it cannot be reduced under physiological conditions, which prevents its proper incorporation into protoporphyrin IX to form heme. This disruption is particularly detrimental to rapidly dividing cells, such as cancer cells and certain inflammatory cells, which have a high demand for iron.
The most prominent clinical application under investigation for maltolate is in the field of oncology. It is being studied as an oral anti-neoplastic agent for various cancers, including hepatocellular carcinoma, non-small cell lung cancer, and bladder carcinoma. Its ability to target iron-dependent processes also makes it a candidate for therapeutic use in diseases characterized by pathological inflammation or pathogenic microorganisms that are highly iron-dependent.
From a pharmaceutical perspective, maltolate is typically administered as an oral solid dosage form, such as a capsule. Its high lipid solubility contributes to its favorable oral bioavailability, a significant advantage over earlier ionic formulations like nitrate, which required intravenous infusion. This oral availability facilitates its use in extended outpatient treatment regimens and clinical trials.
The safety profile of maltolate is characterized by side effects that are generally manageable. The most common adverse effects observed in clinical trials are related to gastrointestinal irritation, including nausea and constipation. Unlike traditional cytotoxic chemotherapy, it does not cause significant myelosuppression (bone marrow suppression), representing a different and often better-tolerated side effect profile. Its development represents a novel approach to targeting cellular metabolism in proliferative diseases.
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