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2-Fluoroaniline CAS:348-54-9

Name: 2-Fluoroaniline CAS:348-54-9
Brand: Orient
SKU: pr2511261299
Price: 5 USD
Availability: InStock

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CAS No.:

348-54-9

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-26

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information

Description

2-Fluoroaniline Basic information

Product Name:	2-Fluoroaniline
Synonyms:	2-FLUOROANILINE;2-Fluoranilin;Benzenamine, 2-fluoro-;1-AMINO-2-FLUOROBENZENE;AKOS 91139;AKOS BBS-00003628;LABOTEST-BB LTBB000714;FLUOROANILINE-2
CAS:	348-54-9
MF:	C6H6FN
MW:	111.12
EINECS:	206-478-9
Product Categories:	Fluoro-Aromatics;Anilines, Aromatic Amines and Nitro Compounds;Fluorobenzene;Heterocyclic Compounds;Benzene derivatives;Fluorobenzene Series;Fluorine series;amine \| alkyl Fluorine
Mol File:	348-54-9.mol

2-Fluoroaniline Chemical Properties

Melting point	-29 °C
Boiling point	182-183 °C(lit.)
density	1.151 g/mL at 25 °C(lit.)
vapor pressure	1 hPa (20 °C)
refractive index	n20/D 1.544(lit.)
Fp	140 °F
storage temp.	Store below +30°C.
solubility	17g/l
pka	3.2(at 25℃)
form	Liquid
color	Clear colorless
Specific Gravity	1.151
Water Solubility	17 g/L (20°C)
BRN	1524219
CAS DataBase Reference	348-54-9(CAS DataBase Reference)
NIST Chemistry Reference	Benzenamine, 2-fluoro-(348-54-9)
EPA Substance Registry System	o-Fluoroaniline (348-54-9)

Safety Information

Hazard Codes	Xn,T,Xi
Risk Statements	22-37/38-41-36/38-33-23/24/25
Safety Statements	26-39-37/39-45-36/37-28
RIDADR	UN 2941 6.1/PG 3
WGK Germany	2
RTECS	BY1390000
Autoignition Temperature	600 °C
Hazard Note	Toxic/Irritant
TSCA	T
HazardClass	6.1
PackingGroup	III
HS Code	29214210

2-Fluoroaniline Usage And Synthesis

Chemical Properties	2-Fluoroaniline is a clear colorless to brown liquid, toxic, insoluble in water, soluble in ethanol and ether, its vapor and air can form an explosive mixture, which can cause combustion and explosion in case of fire and high heat. Reacts with oxidants. Decomposed by high heat to release toxic gases.
Uses	2-Fluoroaniline (cas# 348-54-9) is a useful reagent for the synthesis of insecticides.
Application	2-Fluoroaniline can be used to synthesize thermosensitive dye FH-102, which is a black thermosensitive dye with wide application and excellent performance. The dye can be used in the production of terminal output printing paper of electronic computer, EEG recording paper, telephone fax paper and transparent thermal film for oil field.
Definition	ChEBI: 2-fluoroaniline is a derivative of aniline in which the hydrogen at position 2 has been substituted by fluorine. It is used as a pharmaceutical intermediate It is a primary arylamine and a fluoroaniline.
Synthesis Reference(s)	Tetrahedron Letters, 25, p. 3415, 1984 DOI: 10.1016/S0040-4039(01)91034-2
General Description	Clear liquid with a mild sweet odor. Sinks in and mixes slowly with water.
Air & Water Reactions	Water soluble.
Reactivity Profile	2-Fluoroaniline is a base. Neutralizes acids to form salts plus water in an exothermic reaction. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard	Inhalation or ingestion causes bluish tint to fingernails, lips and ears indicative of cyanosis; headache, drowsiness, and nausea, followed by unconsciousness. Liquid can be absorbed through skin and cause similar symptoms. Contact with eyes causes irritation.
Fire Hazard	Special Hazards of Combustion Products: Irritating and toxic hydrogen fluoride and oxides of nitrogen may form in fires.
Biological Activity	The metabolism and excretion of the xenobiotic compound 2-fluoroaniline is important due to human exposure in manufacturing. It is found to be very efficiently metabolized, primarily by 4-hydroxylation with subsequent sulfate or glucuronide formation. N-Acetylation is also observed. at least 80% of the dose is excreted in the urine within 24 hr. 2-Fluoroaniline exerts its nephrotoxic effect through 4-hyroxylation and subsequent p-benzoquinonimine formation.
Metabolic pathway	2-Fluoro and 3-fluoroanilines are preferentially hydroxylated at the para-position, and 4-fluoroaniline is both p- and o-hydroxylated to a significant extent by rat liver microsomes and is not accompanied with an NIH shift to give 4-hydroxyl-3-fluoroaniline.

2-Fluoroaniline Preparation Products And Raw materials

Raw materials	Hydrogen-->2-Nitrochlorobenzene-->Potassium fluoride-->Ethyl 2-fluoropropionate-->5-BROMO-2-FLUOROANILINE-->4-Bromo-1-fluoro-2-nitrobenzene
Preparation Products	Flufenoxuron-->carfentrazone-ethyl-->4-Bromo-2-fluorobenzonitrile-->1-(2-FLUOROPHENYL)PIPERAZINE HYDROCHLORIDE-->2-FLUOROPHENYL ISOCYANATE-->4-Chloro-2-fluoroaniline-->3-Bromofluorobenzene-->N,N-Dimethyltryptamine-->(S)-3-AMINO-5-METHYL-2,3-DIHYDROBENZO[B][1,4]OXAZEPIN-4(5H)-ONE HCL-->2-Fluoro-N-methylaniline-->2-Bromo-3-fluoroaniline

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

2-Fluoroaniline

Other Name:

Benzenamine,2-fluoro-;Aniline,o-fluoro-;2-Fluorobenzenamine;o-Fluoroaniline;2-Fluoroaniline;1-Amino-2-fluorobenzene;2-Fluorophenylamine;NSC 10299

CAS No.:

348-54-9

Molecular Formula:

C6H6FN

InChIKeys:

InChIKey=FTZQXOJYPFINKJ-UHFFFAOYSA-N

Molecular Weight:

111.12

Exact Mass:

111.12

BRN:

1524219

EC Number:

206-478-9

UNII:

SE32ZK6617

NSC Number:

10299

UN Number:

2941

DSSTox ID:

DTXSID8059843

HScode:

29214210

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

XLogP3:

1.26

Appearance:

Clear colorless Liquid

Density:

1.1476 g/cm³ @ Temp: 25.00 °C

Melting Point:

-34.6 °C

Boiling Point:

175 °C

Flash Point:

140 °F

Refractive Index:

1.548

Water Solubility:

17 g/L (20°C)

Storage Conditions:

2-8°C

Vapor Pressure:

1 hPa (20 °C)

PKA:

3.2(at 25 °C)

Dissociation Constants:

3.2 (at 25 °C)

Air and Water Reactions:

Water soluble.

Reactive Group:

Aryl Halides

Reactivity Profile:

2-FLUOROANILINE is a base. Neutralizes acids to form salts plus water in an exothermic reaction. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

See More 2-Fluoroaniline Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Skin sensitization, Category 1

Serious eye damage, Category 1

Acute toxicity - Category 3, Inhalation

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 2

Specific target organ toxicity â repeated exposure, Category 1

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H311 Toxic in contact with skin H317 May cause an allergic skin reaction H318 Causes serious eye damage H331 Toxic if inhaled H341 Suspected of causing genetic defects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P203 Obtain, read and follow all safety instructions before use. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P316 Get emergency medical help immediately. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P333+P317 If skin irritation or rash occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell. P391 Collect spillage.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 2-Fluoroaniline Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221
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2-Fluoroaniline CAS:348-54-9

Product Description

Seller Information