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Triphenylphosphine CAS:603-35-0

Name: Triphenylphosphine CAS:603-35-0
Brand: Orient
SKU: pr2511261473
Price: 2 USD
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CAS No.:

603-35-0

Grade:

Industrial Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-26

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Inquiry History

Description

Triphenylphosphine Chemical Properties

Melting point	79-81 °C(lit.)
Boiling point	377 °C(lit.)
bulk density	500-600kg/m3
density	1.132
vapor density	9 (vs air)
vapor pressure	5 mm Hg ( 20 °C)
refractive index	1.6358
Fp	181 °C
storage temp.	Store below +30°C.
solubility	water: soluble0.00017 g/L at 22°C
form	Crystals, Crystalline Powder or Flakes
color	White
Specific Gravity	1.132
Odor	odorless
Water Solubility	Insoluble
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
Merck	14,9743
BRN	610776
Stability:	Stable. Incompatible with oxidizing agents, acids.
InChIKey	RIOQSEWOXXDEQQ-UHFFFAOYSA-N
CAS DataBase Reference	603-35-0(CAS DataBase Reference)
NIST Chemistry Reference	Phosphine, triphenyl-(603-35-0)
EPA Substance Registry System	Triphenylphosphine (603-35-0)

Triphenylphosphine Usage And Synthesis

Chemical properties	Triphenylphosphine is a common organophosphorus compound with the formula P(C6H5)3 - often abbreviated to PPh3 or Ph3P. It is widely used in the synthesis of organic and organometallic compounds. PPh3 exists as relatively air stable, colorless to pale yellow monoclinic crystals at room temperature. It is a colorless to pale yellow transparent oily liquid above the room temperature with skin irritation and a pungent odour. It dissolves in non-polar organic solvents such as benzene and diethyl ether.
Name Reactions	Mitsunobu reactions The triphenylphosphine combines with DEAD to generate a phosphonium intermediate that binds to the alcohol oxygen, activating it as a leaving group. Substitution by the carboxylate, mercaptyl, or other nucleophile completes the process. Ozonolysis reactions Ozonolysis allows the cleavage of alkene double bonds by reaction with ozone. Depending on the work up, different products may be isolated: reductive work-up gives either alcohols or carbonyl compounds, while oxidative work-up leads to carboxylic acids or ketones. Staudinger reactions Triphenylphosphine reacts with the azide to generate a phosphazide, which loses N2 to form an iminophosphorane. Aqueous work up leads to the amine and the very stable phosphine oxide. Appel reactions The reaction of triphenylphosphine and tetrahalomethanes (CCl4, CBr4) with alcohols is a ready method to convert an alcohol to the corresponding alkyl halide under mild conditions. The yields are normally high. This reaction is somewhat similar to the Mitsunobu Reaction, where the combination of a phosphine, a diazo compound as a coupling reagent, and a nucleophile are used to invert the stereochemistry of an alcohol or displace it.
Uses	Triphenylphosphine is first sulfonated with oleum to form the trisulfonic acid. Triphenylphosphine can be used in Wittig synthesis. It is a standard ligand in homogeneous catalysis. Triphenylphosphine is used in the synthesis of an organophosphorus intermediate, trimethyl phosphite in ester exchange method. And then a series of organophosphorus pesticides such as dichlorvos, monocrotophos and phosphamidon can be further obtained. In addition, it can be used as stabilizers in the synthesis of rubber and resins, antioxidants in polyvinyl chloride, and raw material in the synthesis of alkyd resins and polyester resins.
Production methods	In this preparation method, phenol and phosphorus trichloride was used as raw materials. After esterification and vacuum distillation, the product namely triphenyl phosphite can be obtained. 3C6H5OH + PCl3 [15~20 ℃] → (C3H5O) 3P + 3HCl Specific process can be classified into batch and continuous processes. (1) Batch process The phenol was added into the reactor, after warming to melt phosphorus trichloride was added to react with phenol at 70~90 ℃. After the phosphorus trichloride addition was completed, the temperature of reaction mixture was raised to about 150 ℃. After the removal of hydrogen chloride and unreacted phenol dissolved under reduced pressure at a high temperature, the product can be achieved. (2) The use of a tower reactor Phenol was feeding under the condenser located in the upper portion of the tower, while phosphorus trichloride enters above the receptacle located in the lower portion of the tower. Both reacted in the tower, and the product was collected in the receiver, meanwhile by-product hydrogen chloride was introduced into the absorber tower via the upper end of the condenser. After some process of the crude ester such as distillation, the product can be obtained.
Description	Triphenylphosphine: a member of tertiary phosphines Triphenylphosphine (TPP) is a member of tertiary phosphines, which is phosphane, in which the three hydrogens are replaced by phenyl groups. It has a role as a reducing agent and an NMR chemical shift reference compound. It is a crucial ligand utilized in the Wittig reaction for alkene synthesis. This reaction involves the formation of alkyliden-etriphenylphosphoranes from the action of butyllithium or another base on the quarternary halide. Triphenylphosphine is used to synthesise organic compounds due to its nucleophilicity and reducing character.
Chemical Properties	Triphenylphosphine is a white to light tan flaked solid. Insoluble inwater; slightly soluble in alcohol; soluble in benzene, acetone, carbon tetrachloride. Combustible.
Uses	Triphenylphosphine is a versatile and efficient compound with a wide range of applications. It serves as a crucial ligand in homogeneous catalysts for petrochemical and fine chemical production, and as a co-catalyst in the production of isobutanol and n-butanol. It is also the basic raw material for rhodium phosphine complex catalysts, such as Wilkinson's catalyst (RhCl(PPh3)3) for alkene hydrogenation and tetrakis(triphenylphosphine)palladium(0) for C-C coupling reactions in organic synthesis. In the dye industry, it is utilized as a sensitizer, heat stabilizer, light stabilizer, antioxidant, flame retardant, antistatic agent, rubber antiozonant, and analytical reagent. The rhodium and triphenylphosphine catalyst system is employed in the hydroformylation of vegetable oils and their methyl esters, and polymer-supported triphenylphosphine catalyzes the γ-addition of pronucleophiles to alkynoates. It also participates in the Heck reaction of 4-bromoanisole and ethyl acrylate in ionic liquids. Triphenylphosphine can be sulfonated to form trisulfonic acid and is used in Wittig synthesis as a standard ligand in homogeneous catalysis. It is involved in the synthesis of trimethyl phosphite, leading to the production of organophosphorus pesticides like dichlorvos, monocrotophos, and phosphamidon. Furthermore, it is used as a stabilizer in rubber and resin synthesis, an antioxidant in polyvinyl chloride, and a raw material in the synthesis of alkyd resins and polyester resins. Triphenylphosphine is also used in the synthesis of Chlorambucil, a cytotoxic agent for breast and pancreatic cancers, and in the preparation of α-Tocopherol analogues for monitoring antioxidant status.
Production Methods	Triphenylphosphine is one of the most widely used phosphorus-containing reagents in organic synthesis for many types of transformations such as the Mitsunobu, the Wittig, and the Staudinger reaction. Triphenylphosphine can be prepared in the laboratory by treatment of phosphorus trichloride with phenylmagnesium bromide or phenyllithium. The industrial synthesis involves the reaction between phosphorus trichloride, chlorobenzene, and sodium. PCl3 + 3 PhCl + 6 Na → PPh3 + 6 NaCl

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Certificates

Basic Info

Product Name:

Triphenylphosphine

Other Name:

Phosphine,triphenyl-;Triphenylphosphine;Triphenylphosphorus;Triphenylphosphide;PP 360;P 100;P 100 (accelerator);JC 263;Triphenylphosphane;TPP;NSC 10;NSC 215203;EPCAT-P;PP 200;PPh3;Hokko TPP;T 0519;112771-47-8;630403-25-7;1198579-87-1

CAS No.:

603-35-0

Molecular Formula:

C18H15P

InChIKeys:

InChIKey=RIOQSEWOXXDEQQ-UHFFFAOYSA-N

Molecular Weight:

262.28500

Exact Mass:

262.29

EC Number:

238-154-8

UNII:

26D26OA393

ICSC Number:

0700

NSC Number:

215203|10

UN Number:

3077

DSSTox ID:

DTXSID5026251

Color/Form:

MONOCLINIC PLATELETS OR PRISMS FROM ETHER|WHITE CRYSTALLINE SOLID

HScode:

2919900090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

13.59000

XLogP3:

3.44480

Appearance:

Triphenyl phosphine appears as white crystals. (NTP, 1992)

Density:

1.075 g/cm³ @ Temp: 80 °C

Melting Point:

80.5 °C

Boiling Point:

>360 °C

Flash Point:

181ºC

Refractive Index:

1.5918 (20ºC)

Water Solubility:

H2O: Insoluble

Storage Conditions:

Store at RT.

Vapor Pressure:

5 mm Hg ( 20 °C)

Vapor Density:

9 (vs air)

Toxicity:

LD50 orally in Rabbit: 700 mg/kg LD50 dermal Rabbit > 4000 mg/kg

Odor:

ODORLESS

Experimental Properties:

TRIBOLUMINESCENT

Air and Water Reactions:

Triphenylphosphine is a flammable solid which slowly oxidizes in air to form triphenylphosphine oxide. It is insoluble in water.

Reactive Group:

Amines, Phosphines, and Pyridines

Reactivity Alerts:

Highly Flammable

Reactivity Profile:

TRIPHENYL PHOSPHINE reacts vigorously with oxidizing materials. (NTP, 1992).

Autoignition Temperature:

425 °C

Physical Dangers:

Dust explosion possible if in powder or granular form, mixed with air.

See More Triphenylphosphine Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Skin sensitization, Sub-category 1B

Specific target organ toxicity â repeated exposure, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H317 May cause an allergic skin reaction H373 May cause damage to organs through prolonged or repeated exposure
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P317 If skin irritation or rash occurs: Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P319 Get medical help if you feel unwell.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from oxidants and acids. Keep in a well-ventilated room.

See More Triphenylphosphine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
Malaysia	Triphenylphosphine	10000 KG	Feb 18, 2025
Russia	Triphenylphosphine	10 MT	Jan 14, 2026
Malaysia	Triphenylphosphine (TPP) Flakes	50 MT	Dec 31, 2024
Russia	Triphenylphosphine	1 MT	May 6, 2024

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Triphenylphosphine CAS:603-35-0

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