Lumefantrine 82186-77-4

Focusing on innovative research, development, and production in the field of fine chemicals, we prioritize technology, quality, and market orientation. We collaborate with global partners to build a high-tech chemical industry chain and promote sustainable development in the industry.

The company's main products include pharmaceutical intermediates, food additives, essence, spices and plant extracts. The products have passed international certification and are exported to Europe, America, Japan, South Korea and Southeast Asia.

Product Name: Lumefantrine Synonyms: (9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-9H-fluorene-4-methanol;CPG-56695;Benwuchun;Benflumentol;benflumetol;Lumefantrine;BENFLUMETOL (OR LUMEFANTRINE);(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-a-[(dibutylamino)methyl]-9H-fluorene-4-methanol CAS: 82186-77-4 MF: C30H32Cl3NO MW: 528.94 EINECS: 617-303-4 Product Categories: Pharmaceutical intermediates;Antibiotics;Amines;Aromatics;Intermediates & Fine Chemicals;API;Pharmaceuticals;82186-77-4 Mol File: 82186-77-4.mol Lumefantrine Chemical Properties Melting point  129-131°C Boiling point  642.5±55.0 °C(Predicted) density  1.252 storage temp.  15-25°C solubility  DMSO: ≥20mg/mL form  powder pka 13.44±0.20(Predicted) color  yellow Merck  14,5597 InChIKey DYLGFOYVTXJFJP-MYYYXRDXSA-N SMILES C12C(C(CN(CCCC)CCCC)O)=CC(Cl)=CC=1/C(=C\C1C=CC(Cl)=CC=1)/C1C=C(Cl)C=CC2=1 CAS DataBase Reference 82186-77-4(CAS DataBase Reference) Safety Information WGK Germany  3 HS Code  29221950 Hazardous Substances Data 82186-77-4(Hazardous Substances Data) MSDS Information Lumefantrine Usage And Synthesis Antimalarial drug Benflumetol and artemether are the widely used antimalarial drugs currently in clinical , they are the main ingredients of the well-known anti-malarial drugs called Compound artemether of Novartis ,which can kill plasmodia asexual, insecticidal rate is high, the cure rate is about 95%, but it is invalid in the pre-erythrocytic stage and gametophyte . Animal experiments suggest it is drug with micro toxicity,but the mutagenic and teratogenic tests are negative. It is mainly used for the treatment of falciparum malaria in clinical, especially for the chloroquine-resistant falciparum malaria treatment. Physical and Chemical Properties Yellow crystalline powder, bitter almond smell, tasteless. Soluble in chloroform, slightly soluble in acetone, almost insoluble in alcohol, melting point of 125~131 ℃. Pharmacokinetics Oral absorption is slow, elimination is also slow,it can stay a long time in the body . Tmax after administration is 4~5h, t1/2 is 24~72h. Dosage 4d therapy: Adults eat 800mg at draught on the first day ,on day 2, 3, 4, each 400mg at draught; children daily take 8mg/kg at draught, and continue for 4d, the first dose is doubled, but the first dose does not exceed the maximum dose of 0.6g. The above information is edited by the chemicalbook of Tian Ye. Adverse reactions There are no significant adverse reactions, a small number of patients suffer with electrocardiographic Q~T interval transient mild extending. Precautions Patients with heart, kidney dysfunction,should use with caution. After symptoms are controlled in patients with malignant malaria and the parasite is killed in the pre-erythrocytic stage ,primaquine can be used to kill gametocytes. It is saved in the dark, sealed, cool and dry place. Description Lumefantrine is an antimalarial drug that is used in combination with artemether . The pairing of lumefantrine and artemether is a major form of oral artemisinin combination therapy used against uncomplicated P. falciparum malaria. Lumefantrine also blocks the rapidly activating delayed-rectifier potassium channel (IKr; IC50 = 8.1 μM). Chemical Properties Yellow Solid Uses A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human. Application Lumefantrine has been used: to study its effect on ex-vivo Plasmodium falciparum sensitivity using the tritiated hypoxanthine-based assay as a standard in the quantification of combined tablet formulation using HPTLC as a drug molecule in in vitro growth inhibition assay for in vitro B. caballi growth inhibition studies

First aid measures

General advice Consult a physician. Show this material safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Firefighting measures

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides Nitrogen oxides (NOx) Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.



——  Q&A  ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.