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2-Phenylacetamide 103-81-1

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Unit Price: Get Latest Price
CAS No.:

103-81-1

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

1KG, 5KG, 25KG

Price valid (until):

2026-01-26

Company Type:
Trader
Location:
China
Qualification:
Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

  • Product Description

  • Seller Information

  • Inquiry History

  • Description
    Product Name: 2-Phenylacetamide
    Synonyms: PHENYLACETAMIDE;2-PHENYLACETAMIDE;ALPHA-TOLUAMIDE;ALPHA-PHENYLACETAMIDE;2-phenyl-acetamid;Acetamide, 2-phenyl-;alpha-toluimidicacid;Benzeneacetamide
    CAS: 103-81-1
    MF: C8H9NO
    MW: 135.16
    EINECS: 203-147-0
    Product Categories: Pharmaceutical intermediates;amine series;103-81-1
    Mol File: 103-81-1.mol
    Shop 2-Phenylacetamide 103-81-1-Detailed Image 1

    2-Phenylacetamide Chemical Properties
    Melting point  156 °C
    Boiling point  280-290 °C (dec.)
    density  1.1031 (rough estimate)
    refractive index  1.5589 (estimate)
    storage temp.  Refrigerator
    solubility  Soluble in methanol.
    pka 16.21±0.40(Predicted)
    form  Solid
    color  Plates or leaflets
    Merck  14,7266
    InChI InChI=1S/C8H9NO/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)
    InChIKey LSBDFXRDZJMBSC-UHFFFAOYSA-N
    SMILES C1(CC(N)=O)=CC=CC=C1
    CAS DataBase Reference 103-81-1(CAS DataBase Reference)
    NIST Chemistry Reference Benzeneacetamide(103-81-1)
    EPA Substance Registry System Benzeneacetamide (103-81-1)

    Safety Information
    Hazard Codes  Xi
    Risk Statements  22-36
    Safety Statements  22-24/25-60-36-26
    RTECS  AC7705000
    TSCA  Yes
    HazardClass  IRRITANT
    HS Code  29242990
    Toxicity LD50 ipr-mus: 430 mg/kg PCJOAU 10,579,76
    MSDS Information


    2-Phenylacetamide Usage And Synthesis
    Chemical Properties 2-Phenylacetamide, also known as alpha-toluamide or benzeneacetamide, belongs to the class of organic compounds known as phenylacetamides. These are amide derivatives of phenylacetic acids. Pure crystals are plate shaped and colorless to white. soluble in hot water, ethanol, slightly soluble in cold water, ether and benzene.
    Uses 2-Phenylacetamide is used as a pharmaceutical intermediate in the production of penicillin G and phenobarbital, etc. It is also used in organic synthesis.
    Uses In agriculture, 2-Phenylacetamid can be used in the production of many important intermediates of pesticides, such as carbamine. In the field of dyes: it can react with some monomers with color to produce some important raw materials for blue and purple dyes. In the field of fragrances, it can be used as an important raw material for the synthesis of certain spices and flavors. 2-Phenylacetamide can also be used in the synthesis of organometallic, organic peroxide, organic peroxide ester, and other compounds, and can be used as a crosslinking agent for polymers, a film forming agent for coatings, a plasticizer for plastics, etc.
    Definition ChEBI: 2-phenylacetamide is a monocarboxylic acid amide that is acetamide substituted by a phenyl group at position 2. It has a role as a mouse metabolite. It derives from a phenylacetic acid.
    Preparation Synthesis of 2-phenylacetamide: Add concentrated hydrochloric acid to phenylacetonitrile, stir to dissolve, and react at 50°C for half an hour. Then slowly add water under cooling to separate out crystals, filter after cooling, wash with ice water to obtain crude product. The crude product was washed with sodium carbonate solution, then washed with ice water, and dried to obtain purer phenylacetamide.
    Synthesis Reference(s) Journal of the American Chemical Society, 75, p. 740, 1953 DOI: 10.1021/ja01099a504
    The Journal of Organic Chemistry, 43, p. 402, 1978 DOI: 10.1021/jo00397a005
    Organic Syntheses, Coll. Vol. 4, p. 760, 1963
    Biological Activity 2-Phenylacetamide, the main compound isolated from the seeds of Lepidium apetalum Willd (LA) with estrogenic activities, increases the expression of Estrogen receptorα (ERα), ERβ and GPR30 in the uterus and MCF-7 cells.
    Safety Profile Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.

    First aid measures

    If inhaled

    Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

    Following skin contact

    Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

    Following eye contact

    Rinse with pure water for at least 15 minutes. Consult a doctor.

    Following ingestion

    Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

    Accidental release measures


    Personal precautions, protective equipment and emergency procedures

    Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

    Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

    Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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    ——  Q&A  ——

    Q1:Do you provide sample?

    A: Yes, we can provide free sample, you only need pay the shipping cost.

    Q2: What is the lead time?

    A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

    Q3: How can I buy? What is the payment method?

    A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer, 

    Q4:What if there are quality issues?

    A:We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.



    Certificates

    Basic Info
    Product Name:

    Benzeneacetamide

    Other Name:

    Benzeneacetamide;Acetamide,2-phenyl-;Benzenediacetamide;2-Phenylacetamide;Phenylacetic acid amide;α-Toluamide;α-Phenylacetamide;α-Toluimidic acid;Phenyl-β-acetylamine;Phenacetamide;NSC 1877;4463-20-1

    CAS No.:

    103-81-1

    Molecular Formula:

    C8H9NO

    InChIKeys:

    InChIKey=LSBDFXRDZJMBSC-UHFFFAOYSA-N

    Molecular Weight:

    135.16300

    Exact Mass:

    135.16

    EC Number:

    203-147-0

    UNII:

    5R219M9TJF

    NSC Number:

    1877

    DSSTox ID:

    DTXSID1059282

    HScode:

    3004909090

    Characteristics
    PSA:

    43.09000

    XLogP3:

    1.41470

    Appearance:

    Solid

    Density:

    1.098 g/cm3

    Melting Point:

    157 °C

    Boiling Point:

    244-279 °C

    Flash Point:

    142.6ºC

    Refractive Index:

    1.552

    Water Solubility:

    soluble in methanol.

    Vapor Pressure:

    0.000537mmHg at 25°C

    Toxicity:

    LD50 ipr-mus: 430 mg/kg PCJOAU 10,579,76

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 4, Oral

    Eye irritation, Category 2

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H302 Harmful if swallowed

    H319 Causes serious eye irritation

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    Response

    P301+P317 IF SWALLOWED: Get medical help.

    P330 Rinse mouth.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    Storage

    none

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    pharmaceutical intermediates,peptides,electronic chemicals

    Location:

    Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

    Payment Terms:

    100% TT in advance

    Average lead Time:

    10

    Total Annual Revenue:

    $10 million-$25 million

    Total Employees:

    51-100

    Year of Establishment:

    2024

    A reliable supplier is like insurance.

    We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals,food additives, and other fine chemical products.
    Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

    Website: orientchem.cc
    Email: scarlett@orientchem.cc
    WhatsApp: +86 17753254221

  • Inquiry History
    1 Inquiries
    Country Product Purchase Quantity Date Posted
    Switzerland

    2-Phenylacetamide

    20000 MT Sep 5, 2023
    Post an enquiry for this product
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