Factory Direct Supply High Purity 99%+ KissPeptin-10 KissPeptin 10 high quality

Kisspetin 10 (often abbreviated as kisspeptin-10) is a naturally occurring peptide hormone in the human body that plays a key role in regulating reproductive endocrine function by activating its receptor, GPR54. This hormone stimulates the secretion of gonadotropin-releasing hormone (GnRH), thereby activating the hypothalamic-pituitary-gonadal axis, a key signal for the onset of puberty and regulation of fertility.

Main Actions and Functions:
Regulating Reproductive Function: Kisspeptin-10 is a key hormone in regulating reproductive endocrine function in both women and men, activating the hypothalamic-pituitary-gonadal axis by stimulating GnRH secretion.
Initiating Puberty: Kisspeptin-10 is a key hormone initiating puberty.
Inducing Ovulation: During in vitro fertilization (IVF) treatment, exogenous administration of kisspeptin-10 can induce physiological GnRH release, thereby triggering ovulation and oocyte maturation.
Relevance to Various Diseases: The kisspeptin system plays a role in a variety of reproductive endocrine disorders, providing new research insights into the treatment of conditions such as polycystic ovary syndrome and hyperprolactinemia.

Kisspeptin-10 (mouse, rat) is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10 (mouse, rat) is a ligand for the kissin receptor GPR54 (also known as KISS1). Kisspeptin-10 reduces methotrexate-induced reproductive toxicity and has potential antioxidant activity.

 Applications and Effects:

① Reproductive Regulation: Kisspeptin-10 plays a crucial role in reproductive biology and is a key regulator of the hypothalamic-pituitary-gonadal axis. It primarily regulates gonadal function and the reproductive cycle by binding to the kissin receptor GPR54 (also known as KISS1), influencing the secretion of gonadotropin-releasing hormone (GnRH). In rodent models, kisspeptin-10 plays a crucial role in the onset of puberty and the maintenance of reproductive function.

② Vasoconstriction and Angiogenesis: Kisspeptin-10 not only plays a role in the reproductive system but also has potential effects on the cardiovascular system. Studies have shown that kisspeptin-10 can increase cardiac contractility and induce fibrosis and changes in mitochondrial structure in rat heart tissue. These changes suggest that kisspeptin-10 may play a key role in the pathogenesis of heart disease.

③ Antioxidant Activity: Studies have shown that kisspeptin-10 also has potential antioxidant activity, potentially reducing the reproductive toxicity induced by certain drugs, such as methotrexate, this makes kisspeptin-10 a potential therapeutic peptide that can be used to improve sexual desire, muscle growth, and other aspects.