Frag 17-23

Name:  Lynn
Wechat：  15914422644

Tel：+86  15914422644

Whatsapp: +852 6252 8290

Email：    guangsheng 5   @zgguangsheng.com

1. Core Molecular & Physicochemical Specifications

2. Mechanism of Action

1. Cell Migration & Proliferation: Promotes migration and proliferation of fibroblasts, endothelial cells, and keratinocytes, accelerating wound closure and tissue repair.
2. Angiogenesis: Stimulates endothelial cell growth and tube formation, enhancing nutrient/oxygen delivery to damaged tissues via new blood vessel formation.
3. Anti-Inflammatory Activity: Modulates pro-inflammatory cytokines (e.g., TNF-α, IL-6) and reduces inflammatory cell infiltration, alleviating swelling and tissue damage.
4. Collagen Synthesis: Enhances fibroblast-derived collagen production, improving extracellular matrix (ECM) reconstruction and tissue structural integrity.
5. ECM Remodeling: Regulates matrix metalloproteinases (MMPs) to balance ECM degradation and synthesis, preventing excessive fibrosis.

3. Key Research Applications

3.1 Tissue Repair & Regeneration

• Wound Healing: Accelerates skin wound closure, reduces scar formation, and improves healing quality in preclinical models.
• Musculoskeletal Recovery: Promotes repair of muscle strains, tendon/ligament injuries, and bone fractures by enhancing cell migration and angiogenesis.
• Organ Protection: Preclinical studies show potential in reducing myocardial infarction size, improving renal function after injury, and mitigating liver fibrosis via anti-inflammatory and anti-fibrotic effects.

3.2 Anti-Inflammation & Fibrosis

• Inflammatory Diseases: Investigated for treating rheumatoid arthritis, inflammatory bowel disease (IBD), and asthma by suppressing excessive immune responses.
• Fibrosis Prevention: Inhibits collagen deposition in organs like the heart, kidneys, and lungs, reducing fibrotic tissue formation.

3.3 Other Research Directions

• Neurological Repair: Explored for neuroprotective effects in stroke, spinal cord injury, and neurodegenerative disease models via angiogenesis and anti-apoptosis.
• Sports Science: Studied for enhancing recovery from sports-related injuries (misuse in sports may violate anti-doping regulations).

4. Production & Quality Control

4.1 Manufacturing Process

• Solid-Phase Peptide Synthesis (SPPS): Uses Fmoc/t-Boc chemistry to assemble the 7-amino acid sequence, with N-terminal acetylation for stability.
• Purification: Reverse-phase high-performance liquid chromatography (RP-HPLC) to achieve ≥98% purity; lyophilization for long-term storage.

4.2 Quality Testing

• Purity: RP-HPLC confirms ≥98% purity; mass spectrometry (MS) verifies molecular weight.
• Identity: Amino acid analysis and peptide mapping confirm sequence accuracy.
• Safety: Sterility, endotoxin, and residual solvent testing to meet research standards.
• Stability: Accelerated stability testing ensures shelf-life under recommended storage conditions.

5. Safety & Precautions

5.1 Preclinical Safety Profile

• Low Toxicity: No significant acute toxicity reported in animal studies at typical research doses.
• Immunogenicity: Low risk of antibody formation due to short sequence and natural origin.
• Side Effects: Mild local reactions (injection site redness/pain) may occur; no systemic adverse effects observed in preclinical trials.

5.2 Handling Guidelines

• Research-Only Use: Not approved for human clinical use; restricted to in vitro and preclinical animal studies.
• Storage: Keep at -20°C (long-term) or 2–8°C (short-term); avoid light and moisture.
• Administration: Intramuscular (IM), subcutaneous (SC), or local injection in animal models; dosage varies by species and application (typically 0.1–1 mg/kg).