China Manufacturer Supply High Purity Doxycycline hyclate Powder CAS 24390-14-5

Doxycycline hyclate is a tetracycline antibiotic used to treat a wide range of bacterial infections. It is effective against both Gram-positive and Gram-negative bacteria and is commonly prescribed for conditions such as respiratory infections, skin infections, sexually transmitted infections, and as prophylaxis for malaria. Doxycycline hyclate also has applications in treating acne and certain inflammatory conditions due to its immunomodulatory properties.

Mechanism of Action

Doxycycline hyclate works by inhibiting bacterial protein synthesis. Its mechanism includes:
Binding to the 30S Ribosomal Subunit: Doxycycline binds to the 30S ribosomal subunit of bacteria, preventing the binding of aminoacyl-tRNA to the ribosomal A site. This action halts protein synthesis, effectively stopping bacterial growth (bacteriostatic effect) .
High Lipophilicity: Doxycycline's lipophilic nature allows it to penetrate cell membranes easily, enhancing its ability to reach target sites within various tissues.

Applications

Doxycycline hyclate is indicated for:
Bacterial Infections: Including respiratory tract infections, skin infections, and urinary tract infections.
Sexually Transmitted Infections: Such as chlamydia, syphilis, and gonorrhea.
Acne Treatment: Effective in managing acne vulgaris and rosacea.
Malaria Prophylaxis: Used to prevent malaria in travelers to endemic areas.
Other Infections: Including Lyme disease, cholera, tularemia, and Rickettsial infections.

Routes of Administration

Doxycycline hyclate is available in several formulations:
Oral Tablets/Capsules: Commonly prescribed for outpatient treatment.
Delayed-release Capsules/Tablets: Designed for sustained release.
Injectable Form: For intravenous use in hospital settings.
The typical oral dosage ranges from 100 mg to 200 mg daily, depending on the condition being treated.

Safety and Side Effects

Common Side Effects
Patients taking doxycycline may experience:
Nausea
Vomiting
Diarrhea
Photosensitivity (increased sensitivity to sunlight)
Skin rash or itching
Mild diarrhea.
Serious Side Effects
Serious adverse reactions can include:
Severe Allergic Reactions: Such as anaphylaxis.
Intracranial Hypertension: Symptoms include headache and blurred vision.
Esophageal Irritation or Ulceration: Particularly if taken without sufficient water.
Hepatic Injury: Rarely reported but can occur with prolonged use.

Pharmacokinetics

Absorption and Distribution
Doxycycline is well absorbed from the gastrointestinal tract, with peak plasma concentrations reached within 1–2 hours after oral administration. It has a high plasma protein binding rate (80–90%) and penetrates various tissues effectively.
Metabolism and Excretion
The drug is primarily metabolized in the liver and excreted through urine and feces. Its elimination half-life ranges from 15 to 30 hours, allowing for convenient dosing schedules.

Xian Harmonious Natural Bio- Technology Co., Ltd was founded in 2017, and located in Xian International Logistics Industrial Zone, Xian City. Shaanxi Province, China. Now it is the leading researcher and one of the biggest manufacturer in high technology APl area.

There are 8 experts in our research team. We insistin innovation and produce high quality products. And GMP standard workshop and complete stainless extraction equipment.

We have 2 sales deparments over 20 people and sell our products allover the word. We also have strong professional research and development team talented personnel and completely equipped laboratoy for the quality controlling. Various Detection Device is equipped in HNB company, such as HPLCGC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.
HNB mainly engaged in export of products incuding,without limitation., pharmaceutical raw materials both for vet and human, also Vitamins, Amino Acids minerals, peptides, plant extract, feed and food additives. Our company's business is based on Honest, Trustwortly, Constanty to Go Beyond and Achieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends from both home and abroad.
Passion to innovate, Power to deliver !

Q1 Can i get some samples?

A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2 How to start orders or make payments?

A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information.

Payment by T/T,or Paypal or Escrow(Alibaba).

Q3 How to confirm the Product Quality before placing orders?

A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier

to us and take the samples. You can send us your product specifications and requests,we will manufacture

the products according to your requests.

Q4 What’s your MOQ?

A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge

is 100% paid.

Q5 How about delivery leadtime?

A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)

Q6 Is there a discount?

A6 Different quantity has different discount.

Q7 How do you treat quality complaint?

A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem

caused by us, we will send you free goods for replacement or refund your loss.

Q8 How to contact us ?

A8 You can choose your interested products and send inquiry to us.