Garcinia cambogia Fruit Extract: Reduces High-Fat Diet-Induced Visceral Fat Accumulation and Blood Lipid Levels in Preclinical Models

I. Introduction

Carnosine (chemical name: β-alanyl-L-histidine) is a dipeptide composed of β-alanine and L-histidine, widely present in human muscle and brain tissues. As a natural antioxidant, carnosine possesses functions such as scavenging free radicals, inhibiting glycation reactions, and protecting cell membranes, playing a crucial role in human health.

Characteristics:

• Strong antioxidant properties: Carnosine can neutralize reactive oxygen species (ROS), preventing lipid peroxidation and protein oxidative damage.
• Anti-glycation effects: By competing with sugars for binding, carnosine prevents protein glycation and reduces the formation of advanced glycation end products (AGEs).
• Promotion of cell regeneration: Carnosine extends the regeneration cycle of fibroblasts, enhancing collagen and elastin synthesis.
• Low toxicity: Carnosine is non-toxic and highly safe, suitable for long-term use.

II. Application Areas

1. Anti-aging:
   • Efficacy: Reduces wrinkles and fine lines, improves skin elasticity, and delays skin aging.
   • Application products: Anti-aging serums, creams, eye creams, etc.
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2. Whitening and spot-fading:
   • Efficacy: Inhibits melanin production, lightens pigmentation and acne marks, and evens out skin tone.
   • Application products: Whitening serums, spot-fading creams, whitening masks, etc.
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3. Acne prevention and treatment:
   • Efficacy: Regulates sebum secretion, reduces sebum overflow, and prevents acne recurrence.
   • Application products: Acne gels, repairing lotions, oil-controlling toners, etc.
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4. Improvement of cognitive function:
   • Efficacy: Protects nerve cells, improves memory and learning ability.
   • Application products: Neuroprotective health supplements (mainly used in research, not yet widely commercialized).
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5. Sports nutrition supplementation:
   • Efficacy: Enhances muscle endurance and strength, promotes post-exercise recovery.
   • Application products: Sports nutrition supplements, energy drinks, etc.
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6. Cardiovascular health:
   • Efficacy: Reduces oxidative stress and inflammation, protects the cardiovascular system.
   • Application products: Cardiovascular health supplements (added in some products).

III. Mechanism of Action

1. Antioxidant effects:
   Carnosine prevents oxidative damage to cell membranes and proteins by scavenging free radicals, delaying aging.

2. Anti-glycation effects:
   Carnosine competes with sugars for binding, preventing protein glycation and reducing AGEs, thus protecting collagen and elastin.

3. Promotion of cell regeneration:
   Carnosine extends the regeneration cycle of fibroblasts, promoting collagen and elastin synthesis, enhancing skin elasticity.

4. Regulation of immunity:
   Carnosine regulates cellular and humoral immunity, enhancing the body's immune function.