Natural Fisetin Free Radical Scavenging Calming Firming Complex Beauty Essence

1. Description

Fisetin is a naturally occurring flavonoid compound widely found in fruits and vegetables such as strawberries, apples, persimmons, grapes, onions, and cucumbers. Its molecular formula is C₁₅H₁₀O₆, and its molecular weight is approximately 286.24 g/mol. It appears as yellow needle-like crystals or yellowish-brown to yellow powder, with a melting point of 330°C (decomposition). Regarding solubility, it is soluble in DMSO (28.62 mg/mL), ethanol (2.86 mg/mL), acetone, and acetic acid, but is practically insoluble in water, benzene, and petroleum ether. It should be stored in a sealed container at 2–8°C, protected from light. This compound exhibits oral bioavailability and is a multi-target natural product that acts on various signaling pathways, including CDK6, PI3K/Akt/mTOR, and NF-κB. It possesses multiple biological activities, including antioxidant, anti-inflammatory, anti-aging, and neuroprotective effects.

2. Application

(1) Research on anti-aging and extending healthy lifespan: As senotherapeutic agents, these compounds are studied for their ability to clear senescent cells, slow the aging process, and extend healthy lifespan.

(2) Research on neurodegenerative diseases: Studies are conducted on their neuroprotective effects in diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, exploring their potential to improve cognitive function and slow disease progression.

(3) Oncology Research: Studies on the anti-proliferative and pro-apoptotic mechanisms in various cancers (such as prostate cancer, liver cancer, and melanoma), exerting antitumor activity by inhibiting pathways such as CDK6, PI3K/Akt, and mTOR.

(4) Inflammation and Immunology Research: Studies on anti-inflammatory mechanisms in inflammatory diseases such as acute pancreatitis, deep vein thrombosis, and neuroinflammation, exerting effects by regulating signaling pathways such as NF-κB and MAPK.

(5) Cardiovascular Disease Research: Studies on the protective effects against cardiovascular diseases such as atherosclerosis and ischemia-reperfusion injury, improving disease progression through mechanisms such as the inhibition of ferroptosis-related oxidative stress.

(6) Metabolic Disease Research: Used in studies on the regulation of metabolic disorders such as diabetes and obesity, involving the activation of the AMPK signaling pathway.

(7) Analytical Standards and Research Tools: Serves as an analytical standard for content determination, pharmacological experiments, and bioactivity screening, and is used for research purposes such as cell-based drug delivery and animal experiments.

3. Main Efficacy

(1) Antioxidant effects: Effectively scavenges free radicals and protects cells from oxidative stress damage; upregulates glutathione levels and enhances the endogenous antioxidant defense system.

(2) Anti-inflammatory effects: Inhibits the production of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6); exerts anti-inflammatory effects by inhibiting the activation of nuclear factor κB (NF-κB).

(3) Anti-aging effects: Acts as a senolytic agent, selectively eliminating senescent cells, reducing the senescence-associated secretory phenotype (SASP), and delaying tissue aging.

(4) Neuroprotective effects: Demonstrates neuron-protective effects in various neurodegenerative disease models, including Huntington’s disease; activates the ERK signaling pathway to improve long-term memory.

(5) Antitumor activity: Inhibits the proliferation of various cancer cells, including prostate cancer; induces apoptosis by inhibiting signaling pathways such as CDK6, PI3K/Akt, and mTOR.

(6) Cardiovascular protection: Inhibits the progression of atherosclerosis and alleviates myocardial ischemia-reperfusion injury; exerts a protective effect by inhibiting oxidative stress associated with ferroptosis.

(7) Enzyme inhibitory activity: Inhibits the activity of various enzymes, including cyclin-dependent kinase 6 (CDK6) and fatty acid synthase (FASN); also inhibits DNA methyltransferase 1 (DNMT1).