Name | Lactoferrin |
CAS number | 146897-68-9 |
Description | Lactoferrin is a multifunctional iron-binding glycoprotein belonging to the transferrin family, and the CAS number 146897-68-9 is specifically associated with the bovine (cow) version of this protein . |
Structural formula |  |
Molecular Formula | C141H224N46O29S3 |
Molecular Weight | 3123.82 g/mol |
Appearance | White powder |
Quality Standard | 99% |
Storage Condition | Cool dry place( away from the light) |
Shelf Life | >2 years if stored properly |
Sample package | Aluminium foil bag |
Commercial package | Aluminium Tin, Fiber drum |
Origin | China |
Lactoferrin More Info
Lactoferrin is a multifunctional iron-binding glycoprotein belonging to the transferrin family, and the CAS number 146897-68-9 is specifically associated with the bovine (cow) version of this protein . It is a naturally occurring protein abundantly found in mammalian milk, particularly bovine milk, as well as in other bodily secretions such as tears, saliva, and bile . Structurally, it is a globular glycoprotein with a molecular weight of approximately 80 kDa and is composed of a single polypeptide chain that folds into two homologous lobes, known as the N-lobe and C-lobe, each capable of reversibly binding one ferric iron ion .
The primary biological function of lactoferrin is its high-affinity binding to iron, which plays a crucial role in regulating free iron concentrations in the body and various bodily fluids . This iron-sequestering ability is fundamental to its antimicrobial mechanism, as it inhibits the growth of a wide range of iron-dependent microorganisms, including various bacteria, viruses, fungi, and protozoa, by depriving them of this essential nutrient . Beyond this static effect, lactoferrin also exhibits direct antimicrobial activity by interacting with microbial membranes, leading to the disruption of their integrity and subsequent cell death .
In addition to its antimicrobial properties, lactoferrin is recognized for its diverse bioactivities, which have made it a significant subject of scientific research. It has been shown to possess immunomodulatory properties, helping to regulate cytokine production and modulate inflammatory responses . Furthermore, studies have highlighted its potential roles in promoting wound healing, supporting gastrointestinal health, and exhibiting anticancer properties, which may be mediated through mechanisms such as the inhibition of angiogenesis and modulation of cellular proliferation .
Lactoferrin for research and laboratory use is available from various sources, including those derived from natural bovine milk and those produced via recombinant technology, such as expression in genetically modified rice . As a certified reference material (CRM), it is used as a starting material for calibrators or controls in a variety of analytical testing applications, including LC-MS/MS for allergen testing, infant formula analysis, and nutritional or diagnostic testing . It is typically supplied as a pinkish to light red powder, and proper storage conditions, generally at 2-8°C or -20°C for long-term preservation, are essential for maintaining its stability . It is crucial to note that this product is intended for research, laboratory, or manufacturing use only and is not approved for direct human or therapeutic use .
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