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Sodium methoxide124-41-4

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$33-34/MT FOB

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CAS No.:

124-41-4

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-17

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Qingdao Orient Chemical Co.,LTD

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Trader

Location:

China

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pharmaceutical intermediates,peptides,electronic chemicals

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Description

Product Detail

Sodium Methoxide Basic information

Outline Soda process for producing sodium methylate Sodium process for producing sodium methylate The comparison soda process with sodium process Solution quality reference standard How to separate solid sodium hydroxide and sodium methylate Production Process Identification test Chemical properties Uses Production method Category

Product Name:	Sodium Methoxide
Synonyms:	feldalatnm;Methanol, sodium salt;Methanol,sodiumsalt;methoxysodium;methylatedesodium(french);Sodium methoxide, anhydrous powder, pure;Sodium methoxide, titrant, (0.5 M in methanol), pure;SODIUM METHOXIDE 25% in METHYL ALCOHOL
CAS:	124-41-4
MF:	CH3NaO
MW:	54.02
EINECS:	204-699-5
Product Categories:	Sodium Methylate (30% solution in methanol);Classes of Metal Compounds;Organics;Na (Sodium) Compounds (excluding simple sodium salts);Typical Metal Compounds;metal alkoxide;124-41-4
Mol File:	124-41-4.mol

Sodium Methoxide Chemical Properties

Melting point	-98 °C
Boiling point	65 °C
bulk density	500-600kg/m3
density	0.97 g/mL at 20 °C
vapor density	1.1 (vs air)
vapor pressure	50 mm Hg ( 20 °C)
refractive index	1.3700
Fp	11 °C
storage temp.	Store at +5°C to +30°C.
solubility	Miscible with ethanol, methanol, fats and esters.Immiscible with hydrocarbons and organic solvents.
pka	15.17[at 20 ℃]
form	Powder
color	clarity
Specific Gravity	0.945
PH	11 (20°C, 20g/L in H2O)
explosive limit	36%
Water Solubility	reacts
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
Merck	14,8643
BRN	3592982
Exposure limits	ACGIH: Ceiling 2 mg/m3 OSHA: TWA 2 mg/m3 NIOSH: IDLH 10 mg/m3; Ceiling 2 mg/m3
Dielectric constant	1.5（Ambient）
Stability:	Stability Highly flammable. Reacts violently with water. Keep container dry. Incompatible with water, acids, chlorinated solvents.
InChI	1S/CH3O.Na/c1-2;/h1H3;/q-1;+1
InChIKey	WQDUMFSSJAZKTM-UHFFFAOYSA-N
SMILES	[Na+].C[O-]
LogP	-0.77 at 25℃
CAS DataBase Reference	124-41-4(CAS DataBase Reference)
NIST Chemistry Reference	Sodium methoxide(124-41-4)
EPA Substance Registry System	Sodium methoxide (124-41-4)

Safety Information

Hazard Codes	F,T,C
Risk Statements	11-23/24/25-34-39/23/24/25-36/38-14-36/37/38-22-10
Safety Statements	8-16-26-43-45-7-36/37-7/8-36/37/39
RIDADR	UN 1289 3/PG II/III (SODIUM METHYLATE SOLUTION in alcohol)
RIDADR	UN 1431 4.2/PG II (SODIUM METHYLATE)
WGK Germany	1
RTECS	PC3570000
F	9-21
Autoignition Temperature	878 °F
TSCA	TSCA listed
HazardClass	4.2
PackingGroup	II
HS Code	29051900
Storage Class	4.2 - Pyrophoric and self-heating hazardous materials
Hazard Classifications	Acute Tox. 4 Oral Flam. Sol. 1 Met. Corr. 1 Self-heat. 1 Skin Corr. 1A
Hazardous Substances Data	124-41-4(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 2037 mg/kg LD50 dermal Rat > 2000 mg/kg

MSDS Information

Provider	Language
Sodium methanolate	English
SigmaAldrich	English
ACROS	English
ALFA	English

Sodium Methoxide Usage And Synthesis

Outline	Sodium methanolate is one of alkoxides that are generated by methanol. Its chemical formula is CH3ONa. It is strong base that is commonly used in organic synthesis. Sodium methanolate is often stored in methanol, ethanol or the like alcohol solvent. It can generate suspension when it dissolves in ether. It can decompose into methanol and sodium hydroxide with water: CH3ONa + H2O→CH3OH + NaOH Sodium methanolate product has two forms: solid and liquid. Solid is pure sodium methanolate. The liquid is methanol solution of sodium methanolate and the content of sodium methylate is 27.5% to 31%. Liquid sodium methanolate is colorless or slightly yellow viscous liquid. It is sensitive to oxygen. It is flammable, explosive and easily hygroscopic. It is soluble in methanol and ethanol, and can decompose into methanol and sodium hydroxide with water. It decomposes at 126.6℃ in the air. It is not soluble in benzene and toluene. It is strong irritant and highly corrosive. Sodium methanolate can be used as condensing agent, strong alkaline catalyst and methoxy agent for the preparation of vitamin B1, vitamin A, sulfadiazine and other drugs. Few can be used in production of pesticides. It can also be used as catalyst in processing edible fats and oils (especially processing lard). It is used as analytical reagent. Solid sodium methanolate is colorless amorphous powder. It is sensitive to oxygen, and it is flammable. It is soluble in methanol and ethanol, and can decompose into methanol and sodium hydroxide with water. It decomposes at 126.6℃ in the air. It is mainly used for the production of sulfa drugs, VB6 and VA. Sodium methylate is a kind of catalyst for organic synthesis. It can be used for the production of pesticides and oil processing industries. Solid sodium methanolate and sodium methoxide methanol solution Sodium methylate is a kind of mature chemical products. It has several decades of production history in China. The overall price is high in the south than in the north. Its price is 4500 yuan/T in the southwest, and 4,000 yuan/T in Shandong. Its price changed little with the increase of methanol’s price in 2004. The profit of per ton of product is 500 to 700.
Soda process for producing sodium methylate	Sodium methylate is prepared by the reaction of methanol with sodium hydroxide for soda method. Their reaction is as follows: CH3OH + NaOH→CH3ONa + H2O 1. The preparation of methanol lye Crush the solid sodium hydroxide. Then add it into melting pot base containing methanol (99.8%) in proportion. Start circulating pump, and dissolve the sodium hydroxide below 70℃. When its content is 20% to 23%, cool down to 40℃ and inject into the settling tank. Stand 12h and spare. 2. The preparation of sodium methylate Pass into the steam to the vaporization pot and reaction tower mezzanine. Heat it and control the temperature at 85~100℃. Add anhydrous methanol to vaporization pot at the flow rate of 180L/h. Meanwhile add methanol lye in the top of the reaction tower at the flow rate of 25kg/h. Methanol gas containing 2% of water produced by the reaction from the reaction distill the reaction tower overhead into the purification distillation column to remove water. Then it becomes absolute methanol recycling. Control the temperature of reaction bottoms (i.e. vaporization pot) at 65~70℃, and check the bottoms. When containing 27%~31% Sodium methanolate, 1% or less of the free base, products are obtained. The yield is 86% (as sodium hydroxide). Fixed consumption of the process is as follows: methanol (95%) 973kg/t, sodium hydroxide (99.5%) 209kg/t. The above information is edited by the chemicalbook of Ge Qian.


Solution quality reference standard	Item Index Appearance colorless to pale yellow viscous liquid Content (total base number) 29.5%～31.0% Sodium methoxide (NaOCH3) 28.9%～31.0% Sodium hydroxide (NaOH) ≤0.5% Sodium carbonate (Na2CO3) ≤0.1% Water (H2O) ≤0.2% Methanol 69.0%～70.7%
How to separate solid sodium hydroxide and sodium methylate	1. Dissolved in water (sodium alcoholate reacts violently with water to generate alcohol and sodium hydroxide) 2. Distillation (separate alcohol) 3. Evaporation (separate sodium hydroxide) 4. Try to dry alcohol to anhydrous state (repeated distillation) 6. Distill alcohol to get solid alcohol sodium. (It should be avoided being exposed to the air when distilling. If it is exposed to the air or it is taken down before drying up and cooling, the state of alcohol sodium that is separated out is not well. The good one is white. if not, it will be tan is. But it doesn’t have any great impact. It is easy to be prepared.)
Production Process	Solid sodium hydroxide and methanol mix at a certain proportion. After stirring the mixture to dissolve, solid impurities are removed by sedimentation and clarification. The clear liquid is pumped into the top of the dehydration reaction column, while the refined methanol vapor is added from the bottom of the tower with continuous dehydration reaction. Then the product can be obtained from tower bottom. Aqueous methanol vapor is purified from the top of the column into the distillation system, while anhydrous methanol can be used repeatedly.
Identification test	It can react with oxygen and carbon dioxide. It decomposes in water. Sodium test of the solution (IT-28) is positive. After placing 5min, add 0.2ml 25% sodium sulfite solution and 3ml sulfate. Then add 0.2ml chromium changed acid solution (TS-l66). The solution is amaranth to purple.
Chemical properties	Colorless amorphous fine powder. Dissolved in methanol, ethanol.
Uses	1. Sodium methoxide can be used as alkaline condensing agent and catalyst in organic synthesis. It can be used to synthesize perfumes, dyes and the like. It is also the raw material of vitamin B1, A and sulfadiazine. 2. It can be used as condensing agent in organic synthesis and catalyst in edible oil process. It is also the important raw material to synthesize sulfadiazine, sulfamethoxazole, sulfa synergist and the like. 3. It is the main raw material used for medicine, pesticide. It is also used in dyes and chemical fiber industry. 4. Fatty transesterification catalyst. It can change the fat structure so that it is suitable for margarine. It must be removed in the final food. 5. It is mainly used as condensing agent, strong alkaline catalyst and methoxy agent. It can be used for the preparation of vitamin B1 and A, sulfadiazine and other drugs. And little can be used in the production of pesticides. It can also be used as the catalyst for processing edible fats and oils (especially processing lard). It can also be used as analytical reagent. 6. It is widely used in perfumes, dyes and other industries. It is mainly used as condensing agent, strong alkaline catalyst and methoxy agent for the preparation of vitamin B1 and A, sulfadiazine and other drugs. Little can be used in the production of pesticides. It can also be used as the catalyst for processing edible fats and oils (especially processing lard). It can also be used as analytical reagent. 7. It can be used as condensing agent in organic synthesis.
Production method	It can be obtained by the reaction of sodium hydroxide and methanol in benzene.
Category	Corrosive materials
Chemical Properties	white powder
Uses	Sodium methoxide is mainly used as a condensation agent, a strong alkaline catalyst and a methoxylating agent for the production of B1 and A, sulfadiazine and other , and in small quantities for the production of pesticides. It is also used as a catalyst for treatment ofedible fats and oils, as an intermediate inmany synthetic reactions, to prepare ; and as a reagent in chemicalanalysis.
General Description	Sodium methylate is a white amorphous powder. It reacts with water to form sodium hydroxide, a corrosive material, and methyl alcohol, a flammable liquid. The heat from this reaction may be sufficient to ignite surrounding combustible material or the sodium methylate itself if the water is present in only small amounts. It is used to process edible fats and oils, and to make other chemicals.
Air & Water Reactions	Highly flammable. Ignites in moist air [Wischmeyer 1966]. Reacts with water to produce a mixed solution of sodium hydroxide and methyl alcohol.
Reactivity Profile	SODIUM METHYLATE is a strong base. Reacts with light metals forming H2 gas, with fire and explosion hazards. Sodium methoxide is incompatible with 4-chloronitrobenzene and fluorinated cyclopropenyl methyl ethers, such as perfluoromethoxycyclopropene. The reactions are vigorous and may initiate ignition [Bretherick, 1995, pg. 191].
Hazard	(Solid) Flammable when exposed to heat or flame. (Solution) Flammable, moderate fire risk.

Fire Hazard	Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Flammability and Explosibility	Flammable
Safety Profile	A corrosive and irritating material. It hydrolyzes into methanol and sodlum hydroxide. May ignite spontaneously in moist air. Flammable when exposed to heat or flame. Ignites on contact with water, When heated to decomposition it emits toxic fumes of Na2O.
Purification Methods	It behaves in the same way as sodium ethoxide. It is hygroscopic and is hydrolysed by moist air to NaOH and MeOH. Material that has been kept under N2 should be used.
Toxics Screening Level	The ITSL for sodium methylate has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time.

Sodium Methoxide Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Methanol-->Benzene

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Basic Info

Product Name:

Sodium methoxide

Other Name:

Methanol,sodium salt (1:1);Sodium methoxide;Methanol,sodium salt;Sodium methylate;Sodium methanolate;Feldalat NM;Methoxysodium;SM 24;Sodium methoxylate;SM 28;27419-20-1;879636-47-2;1633026-84-2

CAS No.:

124-41-4

UN No.:

1431

Molecular Formula:

CH4O.Na

InChIKeys:

InChIKey=YWOITFUKFOYODT-UHFFFAOYSA-N

Molecular Weight:

54.02370

Exact Mass:

54.00820

EC Number:

204-699-5

UNII:

IG663U5EMC

ICSC Number:

0771

UN Number:

1431

DSSTox ID:

DTXSID8027030

Color/Form:

Amorphous, free flowing powder|Tetragonal crystals

HScode:

2905199090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

23.06000

XLogP3:

0.04670

Appearance:

Sodium methylate is a white amorphous powder. It reacts with water to form sodium hydroxide, a corrosive material, and methyl alcohol, a flammable liquid. The heat from this reaction may be sufficient to ignite surrounding combustible material or the sodium methylate itself if the water is present in only small amounts. It is used to process edible fats and oils, and to make other chemicals.

Density:

0.45 g/cm³

Melting Point:

127 °C (decomp)

Boiling Point:

80 °C (approx) @ Press: 0.4 Torr

Flash Point:

11ºC

Refractive Index:

1.37

Water Solubility:

Solubility in water: reaction

Storage Conditions:

Flammables area

Vapor Pressure:

50 mm Hg ( 20 °C)

Vapor Density:

1.1 (vs air)

Explosive limit:

vol% in air: 7.3 36

Experimental Properties:

Decomposes in air above 127 °C|Reacts violently with water forming flammable methanol and corrosive sodium hydroxide|White powder /Solvated form/

Air and Water Reactions:

Ignites in moist air [Wischmeyer 1966]. with moist air, autoignition is possible; strong reducing agent; reacts with light metals forming H2 gas, with fire and explosion hazards; reacts violently with water to form methanol and sodium hydroxide, and with acids, causing hazard of methanol ignition [Handling Chemicals Safely 1980 p. 850].

Reactive Group:

Bases, Strong

Reactivity Alerts:

Strong Reducing Agent

Reactivity Profile:

SODIUM METHYLATE is a strong base. Reacts with light metals forming H2 gas, with fire and explosion hazards. Too rapid addition of sodium methylate to a mixture of chloroform and methanol initiated an uncontrolled exothermic reaction between the chloroform and the methylate that caused a violent explosion [MCA Case History 693 1961]. Sodium methoxide is incompatible with 4-chloronitrobenzene and fluorinated cyclopropenyl methyl ethers, such as perfluoromethoxycyclopropene. The reactions are vigorous and may initiate ignition [Bretherick, 5th Ed., 1995].

Autoignition Temperature:

240 °C|>50 °C

Physical Dangers:

Dust explosion possible if in powder or granular form, mixed with air.

See More Sodium methoxide Properties 

Hazard Identification

Classification of the substance or mixture

Self- heating substances and mixtures, Category 1

Skin corrosion, Sub-category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H251 Self-heating; may catch fire H314 Causes severe skin burns and eye damage
Prevention	P235 Keep cool. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling.
Response	P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	P407 Maintain air gap between stacks or pallets. P410 Protect from sunlight. P413 Store bulk masses greater than â¦ kg/â¦lbs at temperatures not exceeding â¦Â°C/â¦Â°F. P420 Store separately. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames, NO sparks and NO smoking. NO contact with water. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants, acids, metals and food and feedstuffs. Dry. Cool. Well closed. Store in an area having corrosion resistant concrete floor. Store in an area without drain or sewer access.

See More Sodium methoxide Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

7 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Sodium Methoxide	50 MT	Aug 5, 2024
Brazil	sodium methoxide 30% solution	1 L	Jun 17, 2025
India	Sodium Methoxide	450 MT	Apr 17, 2025
India	Sodium Methoxide	300 MT	Feb 5, 2025
India	Sodium Methoxide	300 MT	Jan 8, 2025
Oman	Sodium Methoxide	1000 TON	Oct 15, 2023
Sweden	Sodium methoxide 99% Industrial Grade Colorless amorphous powder	20 MT	Aug 24, 2023

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Sodium methoxide124-41-4

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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