Sodium ethoxide | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | CAS 141-52-6

Sodium ethoxide Basic information
Product Name: Sodium ethoxide
Synonyms: Sodium ethoxide 95%;Sodium ethoxide 96%;Sodium ethoxide solution;sodium ethylate solution;Sodiumethoxideinethanol;Sodium ethoxide, 21% in ethanol, pure;SODIUM ETHYLATE SOLUTION, ~21% IN ETHYL ALCOHOL, DENAT.;SODIUM ETHOXIDE, 21 WT. % SOLUTION IN DE NATURED ETHYL ALCOHOL
CAS: 141-52-6
MF: C2H5NaO
MW: 68.05
EINECS: 205-487-5
Product Categories: Organics;metal alkoxide;Classes of Metal Compounds;Na (Sodium) Compounds (excluding simple sodium salts);Typical Metal Compounds;141-52-6;K00001
Mol File: 141-52-6.mol
Shop Sodium ethoxide141-52-6C2H5NaO-Detailed Image 1

Sodium ethoxide Chemical Properties
Melting point 260 °C
Boiling point 91°C
bulk density 300kg/m3
density 0.868 g/mL at 25 °C
vapor density 1.6 (vs air)
vapor pressure <0.1 mm Hg ( 20 °C)
refractive index n20/D 1.386
Fp 48 °F
storage temp. Store at +15°C to +25°C.
solubility Soluble in ethanol and methanol.
form Liquid
color Yellow to brown
Specific Gravity 0.868
PH 13 (5g/l, H2O, 20℃)
explosive limit 2.6-19% (v/v)
Water Solubility Miscible
Sensitive Moisture Sensitive
Hydrolytic Sensitivity 7: reacts slowly with moisture/water
Merck 14,8539
BRN 3593646
Stability: Reacts violently with acids, water. Incompatible with chlorinated solvents, moisture. Absorbs carbon dioxide from the air. Highly flammable.
InChI 1S/C2H5O.Na/c1-2-3;/h2H2,1H3;/q-1;+1
InChIKey QDRKDTQENPPHOJ-UHFFFAOYSA-N
SMILES [Na+].CC[O-]
CAS DataBase Reference 141-52-6(CAS DataBase Reference)
EPA Substance Registry System Ethanol, sodium salt (141-52-6)

Safety Information
Hazard Codes F,C,Xi,N
Risk Statements 11-14-34-36/37/38-68/20/21/22-51/53-20/21/22
Safety Statements 8-16-26-43-45-36/37/39-36-61
RIDADR UN 3274 3/PG 2
WGK Germany 1
F 3-8-10-23
Autoignition Temperature 30 - 50 °C
TSCA TSCA listed
HazardClass 4.2
PackingGroup II
HS Code 29051900
Storage Class 4.2 - Pyrophoric and self-heating hazardous materials
Hazard Classifications Flam. Sol. 1
Self-heat. 1
Skin Corr. 1A
Hazardous Substances Data 141-52-6(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 598 mg/kg
MSDS Information
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Sodium ethoxide Usage And Synthesis
Chemical Properties White powder, sometimes having brownish tinge; readily hydrolyzes to alcohol and sodium hydroxide.
Physical properties White or yellowish powder; hygroscopic; darkens and decomposes on exposure to air; decomposes in water forming sodium hydroxide and ethanol; dissolves in absolute ethanol.
Uses Sodium ethoxide is used in organic synthesis for condensation reactions. It also is a catalyst in many organic reactions.
Uses Sodium ethoxide, 21% w/w in ethanol is used as a strong base in organic synthesis. It finds application in various chemical reactions such as condensation, esterification, alkoxylation and etherifcation. It is actively involved in Claisen condensation, Stobbe reaction and Wolf-kishner reduction. It is an important starting material for the synthesis of ethyl ester and diethyl ester of malonic acid. In Williamson ether synthesis, it reacts with ethyl bromide to form diethyl ether.
Preparation Sodium ethoxide is prepared by reacting sodium with absolute ethanol:
2Na + 2C2H5OH → 2C2H5ONa + H2
Sodium in small quantities is added to absolute alcohol at 10°C. The temperature is raised to warming (to about 38°C). The mixture is cooled again and sodium and absolute alcohol are added gradually followed by careful warming. The process is repeated to obtain a sufficient yield of the p
Definition ChEBI: An organic monosodium salt that has ethoxide as the counterion.
General Description Sodium ethoxide is an alkoxide salt mainly used as a strong base in organic reactions such as deprotonation, dehydration and dehalogenation.
Hazard As for caustic soda, ethanol. Sodium hydroxide is formed when sodium ethylate is exposed to moisture.
Flammability and Explosibility Highly flammable
Purification Methods It is a hygroscopic powder which should be stored under N2 in a cool place. A likely impurity is EtOH which can be removed by warming at 60-80o under high vacuum. It is hydrolysed by H2O to yield NaOH and EtOH. Other impurities, if kept in air for long periods are NaOH and Na2CO3. In this case the powder cannot be used if these impurities affect the reactivity, and a fresh sample should be acquired [IR: Seubold J Org Chem 21 156 1956]. [Beilstein 1 H 311, 1 IV 1289.]

Sodium ethoxide Preparation Products And Raw materials
Raw materials Ethanol-->Sodium hydroxide-->Sodium-->Cyclohexane-->Dehydrolyzing agent-->DL-1-Phenethylalcohol
Preparation Products -->2-METHYLUNDECANAL-->2-METHOXYPROPANDIOIC ACID ETHYL METHYL ESTER-->---->Ethyl 3-methyl-3-phenylglycidate-->2-Amino-4,6-dihydroxypyrimidine-->2-HYDRAZINO-6-METHYLPYRIMIDIN-4-OL-->2-ETHOXY-MALONIC ACID DIETHYL ESTER-->N4-Methylcytosine-->4-(4-FLUOROBENZYLOXY)BENZALDEHYDE-->4-TERT-BUTYL-2,6-DIMETHYL BENZYL ACETATE-->Diethyl isoamylmalonate-->2，2-dichloro-1-(4-ethyoxy phenyl)cy-clopropane carboxylic acid-->polysorbate 40-->Diethyl butylmalonate-->Triethyl 1,1,2-ethanetricarboxylate-->->2-(2-MORPHOLIN-4-YLETHOXY)ANILINE-->Cyclobutanemethanol--->3-CARBETHOXY-2-PIPERIDONE-->Quinazoline, 2-methyl- (6CI,7CI,8CI,9CI)-->ETHYL ISONICOTINOYLACETATE-->2,4,6-TRIAMINO-5-NITROPYRIMIDINE-->DIETHYL 2-(2-CYANOETHYL)MALONATE-->2,4-DIETHOXYPYRIMIDINE-->3-Furoic acid-->P-AMINO-DL-PHENYLALANINE-->Diethyl dipropylmalonate-->3-Aminopyrrolidine-->HYDROXYLAMINE-->Methyltriethoxysilane-->Dimethyl ethylmalonate-->FEMA 2310-->Polysorbate 20-->nony phenyl polyoxyethylene (50～150) ether-->2-Ethoxythiazole-->2-Methoxy-3-methylpyrazine