Exatecan Intermediate 2 (N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide) CAS 182182-31-6 NT

Exatecan Intermediate 2 (CAS 182182-31-6), also known as N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide or compound B, is a key synthetic intermediate in the production of Exatecan (DX-8951). Exatecan is a potent camptothecin analog that functions as a DNA topoisomerase I inhibitor (IC₅₀ = 2.2 μM, 0.975 μg/mL).

Role in Exatecan Synthesis:

Exatecan is a water-soluble camptothecin analog and a non-prodrug that exhibits potent antitumor activity. It is commonly used as a cytotoxin payload in antibody-drug conjugates (ADCs) for targeted cancer therapy. This compound serves as a key building block in the multi-step synthesis of the API, introducing the substituted tetrahydronaphthalenone core structure essential for the drug's biological activity.

Key Features:

• High Purity: ≥ 98% (HPLC), meeting rigorous quality standards

• Key Intermediate: Essential for the synthesis of Exatecan API

• ADC Payload Precursor: Used in the development of antibody-drug conjugates

• Well-characterized with available analytical data (NMR, HPLC, GC, etc.)

Applications:

• Pharmaceutical R&D: As a key intermediate in the synthesis of Exatecan API and ADC payload development

• Analytical R&D: Serves as a reference standard for quality control (QC) and analytical method development (AMV)

• Cancer Research: Used in studies involving topoisomerase I inhibition and targeted cancer therapy

Packaging: ___ (e.g.: 1g, 5g, 10g, 25kg per package, as per customer's request)

Storage: Powder: -20°C for up to 3 years; 4°C for up to 2 years. In solvent: -80°C for 6 months; -20°C for 1 month. Protect from light and moisture.

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