Eribulin Mesylate Intermediate CAS 2835443-65-5 NT

Eribulin Mesylate Intermediate (CAS 2835443-65-5) is a key synthetic intermediate in the production of Eribulin Mesylate, a potent non-taxane microtubule dynamics inhibitor used for the treatment of metastatic breast cancer . This compound is part of the complex polyether macrolide synthesis pathway, which involves a highly challenging, multi-step process to construct the structurally intricate Eribulin molecule.

Chemical Characteristics:

• Complex polyether structure with multiple stereocenters and protecting groups

• Features tert-butyldimethylsilyl (TBDMS) protecting groups, a tosylmethyl group, and a tetrahydropyran ring system

• Molecular formula: C₄₆H₈₀O₉SSi₂ 

• Molecular weight: 865.36 g/mol 

Role in Eribulin Synthesis:

Eribulin Mesylate is a synthetic analog of halichondrin B, a natural product originally isolated from the marine sponge Halichondria okadai. It functions by inhibiting microtubule dynamics, leading to cell cycle arrest and apoptosis in cancer cells. This intermediate contributes to the construction of the highly complex molecular architecture required for the drug's potent biological activity. US DMF (Drug Master File) documentation is available for this compound, supporting regulatory submissions for ANDA and DMF filings .

Key Features:

• High Purity: ≥ 98% (HPLC), meeting rigorous quality standards

• Key Intermediate: Essential for the synthesis of Eribulin Mesylate API

• Regulatory Support: US DMF available for pharmaceutical filings 

• Well-characterized with available analytical data

• Advanced synthesis capability (ultra-low temperature, anhydrous, oxygen-free, hydrogenation, and fluorination reactions available) 

Applications:

• Pharmaceutical R&D: As a key intermediate in the synthesis of Eribulin Mesylate API

• Anticancer Research: Used in studies involving microtubule dynamics and breast cancer therapies

• Regulatory Submissions: Used in ANDA and DMF filings for Eribulin-related drug products

• Organic Synthesis: Advanced polyether synthesis and complex molecule construction

Packaging: ___ (e.g.: 1g, 5g, 10g, 25kg per package, as per customer's request)

Storage: Powder: -20°C for up to 3 years; 4°C for up to 2 years. In solvent: -80°C for 6 months; -20°C for 1 month. Protect from light and moisture. Keep sealed in dry conditions.

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