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I. Angiopep-2 (the most commonly used research carrier peptide, abbreviated as AP2)
Mechanism of action
A 19-amino acid targeting peptide specifically binds to the vascular endothelium and the LRP1 receptor on the blood-brain barrier, mediating transcellular transport. It is mainly used for in vitro model studies of drug delivery. Kopeček / ... 。
The function of penetrating the blood-brain barrier carrier
It can pass through the brain blood vessel barrier and assist in the entry of large molecules, drugs, and nanoparticles into the brain tissue; used in in vitro experiments for Alzheimer's disease, glioma of the brain, and drug delivery for brain nerves, solving the problem that most molecules cannot enter the brain. Wiley Onli... 。
Targeting brain tumor cells enrichment
Brain tumor cells highly express LRP1, and AP2 can directionally carry active substances to accumulate in the lesion area, increasing the effective concentration of brain lesion sites and reducing exposure of unrelated tissues throughout the body.
General carrier for transvascular endothelial transport
All vascular endothelia in the body have corresponding receptors, and in vitro vascular tissue models can promote the penetration of substances through the vascular wall, used for the development of targeted drugs for blood vessels and plaques.
Neural cell delivery assistance
Helping nutrients and antioxidant substances enter neurons, used for brain cell protection and research on the mechanism of nerve injury repair.
II. Ma source anti-caries antibacterial peptide AP2 (Oral Antibacterial Specific Peptide)
Action principle
Rich in tryptophan and arginine cationic peptides, they destroy the structure of bacterial cell membranes. They are stable in saliva environment and have low cytotoxicity.
Strongly kill cariogenic Streptococcus mutans
At extremely low concentrations, they can destroy the cell membranes of cariogenic bacteria and eliminate the core pathogenic bacteria of dental plaque, inhibiting the proliferation of the source bacteria of tooth decay.
Inhibiting the formation of dental plaque biofilm
Below the killing concentration, they can still block bacterial aggregation and film formation, reducing the accumulation of dental calculus and dental plaque.
Oral mild antibacterial, low irritation
The damage to human oral cells due to hemolysis is extremely low, and it does not destroy the normal beneficial bacterial flora in the mouth, different from high-stimulation chemical antibacterial agents.
In vitro effect of caries prevention
In vitro experiments on dental tissue can significantly reduce the probability of acidic corrosion and enamel demineralization, used for the screening of anti-splashing mouthwashes and oral care raw materials.
III. Bee source intestinal antibacterial peptide AP2 (Apidaecin IB optimized peptide)
Action principle
Targeting the ribosomes of Gram-negative bacteria, blocking the synthesis of bacterial proteins, and regulating the stability of intestinal flora.
Inhibiting intestinal pathogenic bacteria
Specifically inhibiting harmful intestinal bacteria such as Salmonella and Escherichia coli, blocking the invasion of pathogenic bacteria into intestinal epithelial cells, reducing the damage of intestinal infection.
Regulating the balance of intestinal probiotics
Increasing the abundance of beneficial bacteria such as bifidobacteria, balancing the structure of intestinal flora, and reducing the excessive reproduction of pathogenic bacteria that causes low-level inflammation in the intestine.
Intestinal anti-inflammatory repair
Down-regulating the inflammatory factors induced by infection, alleviating intestinal mucosal congestion and damage, and reducing the proportion of intestinal tissue apoptosis.
Resisting foodborne intestinal infections
In vitro intestinal tissue models can reduce the colonization of bacteria and the release of toxins, reducing the systemic stress response caused by the body.
IV. PAR2 agonist peptide AP2 (Immune regulatory peptide)
Action principle
Activating proteinase-activated receptor 2, regulating the maturation and migration pathways of dendritic cells and T lymphocytes PMC.
Promoting the maturation and activation of immune cells
Accelerating the migration of dendritic cells to lymphoid tissues, enhancing antigen presentation ability, assisting T cell activation, and enhancing the specific immune response of the body.
Skin immune inflammation regulation
In vitro experiments on epidermal cells regulate local immune signals in the skin, used for the research of allergic dermatitis and contact inflammation mechanisms.
Assisting immune response enhancement
Improving the efficiency of the body's recognition and clearance of exogenous foreign substances and pathogens, and screening raw materials for vaccine adjuvants in vitro.
Hazard Identification
Classification of the substance or mixture
GHS label elements, including precautionary statements
| Pictogram(s) | no data available |
| Signal word | no data available |
| Hazard statement(s) | no data available |
| Precautionary statement(s) |
| Prevention | no data available |
| Response | no data available |
| Storage | no data available |
| Disposal | no data available |
Other hazards which do not result in classification
no data available
Handling and Storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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