—— Product Specifications ——

—— Product Detail ——

• • • • • • • • • • • • • • • • • • • • • • • Product Overview

                                              Amphotericin B is a polyene macrolide antifungal antibiotic with the molecular formula C₄₇H₇₃NO₁₇ and a molecular weight of 924.08 g/mol. This yellow to orange-yellow crystalline powder is a naturally occurring compound produced by the bacterium Streptomyces nodosus, serving as one of the most potent antifungal agents known. The compound is widely used in microbiology research as a selective agent for fungi, as it binds to ergosterol in fungal cell membranes, forming pores that lead to cell death. In pharmaceutical research, amphotericin B is used as a reference standard for antifungal susceptibility testing and as a lead compound for the development of antifungal therapeutics.

                                              Synthetic Process

                                              Amphotericin B is obtained through the following routes:

                                              • Fermentation: Produced by submerged fermentation of Streptomyces nodosus under controlled conditions, followed by extraction and purification.

                                              • Isolation and Purification: The compound is extracted from the fermentation broth using organic solvents and purified by chromatography to obtain high-purity crystalline material.

                                              Mechanism of Action / Application Principles

                                              • Antifungal Activity: Binds to ergosterol in fungal cell membranes, forming ion channels that disrupt membrane integrity and lead to cell death.

                                              • Microbiology Research: Used as a selective agent for fungi in culture media and susceptibility testing.

                                              • Drug Development: Serves as a lead compound for the development of new antifungal agents.

                                              Quality Specifications

                                              
                                              

                                              
                                              

                                              Parameter	Specification
                                              Assay (HPLC)	≥98.0%
                                              Appearance	Yellow to orange-yellow crystalline powder
                                              Specific Rotation [α]²⁰/D	+160° to +180° (c=0.05, DMSO)
                                              Loss on Drying	≤5.0%
                                              Residue on Ignition	≤0.1%

                                              Each batch is accompanied by a Certificate of Analysis (COA).

                                              Packaging & Storage

                                              • Research quantities: 50mg, 100mg amber glass vials

                                              • Bulk quantities: 500mg, 1g amber glass vials

                                              Storage conditions: Store in a tightly sealed container at -20°C or below, protected from light and moisture. Under recommended conditions, shelf life is 24 months.

                                              
                                              

— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.