6-Chloro-3-nitroimidazo[1,2-b]pyridazine

6-Chloroimidazo[l, 2-b]pyridazine (4.95 g, 31.6 mmol) [purchased from Combi-Blocks] was dissolved in 60 mL concentrated sulfuric acid, cooled in an ice bath, and nitric acid (9.9 mL, 158 mmol) was added dropwise while stirring. The reaction was stirred at 0 In a 500 ml single-necked round bottom flask was added3-Amino-6-chloropyridazine(38.86 g, 300 mmol), 40percent aqueous chloroacetaldehyde (58.88 g, 300 mmol), sodium bicarbonate (30.24 g, 360 mmol) and 260 mLTert-butanol, start magnetic stirrer, the reaction flask was stirred at 80 ° C for 7 hours.TLC detection of raw materials 3-amino-6-chloropyridazine reaction is completed, Nitric acid (22.68 g, 360 mmol) was added and reacted for a further 4 hours with stirring.TLC and GC analysis confirmed that the intermediate 6-chloroimidazo [1, 2-b] pyridazine was completely reacted. The reaction mixture was suction filtered and the filter cake was recrystallized from ethyl acetate: n-hexane = 1: 3 to give the pure product 3-nitro-6-chloroimidazo [1, 2-b] pyridazine. The filtrate was extracted with ethyl acetate , The extract was removed by rotary evaporation to give the crude product, which was recrystallized from ethyl acetate: n-hexane = 1: 3 to obtain the pure product3-nitro-6-chloroimidazo [1, 2-b] pyridazine, After drying, the yield was calculated 86.30percent, purity 99.31percentIntermediate 29 6-Chloro-3-nitro-imidazo[1 , 2-b] pyridazine; To 6-chloro-imidazo[1 , 2-b]pyridazine [WO 2007/013673 A1 Page 42, Preparation 38], (5.0 g, 32.55 mmol) was added concentrated sulfuric acid (7.0 ml_, 131.40 mmol). The resulting solution was cooled to 5

Molecular Weight:198.57
XLogP3:1.4
Hydrogen Bond Acceptor Count:4
Exact Mass:197.9944530
Monoisotopic Mass:197.9944530
Topological Polar Surface Area:76
Heavy Atom Count:13
Complexity:221
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes