2-CHLORO-3-METHOXYQUINOXALINE

General procedure: A mixture of sodium (1 mmol, 0.023 g) and alcohol (3 mL) was stirred for 15 min at room temperature. Then 2, 3-dichloroquinoxaline (1 mmol, 0.199 g) was added to the mixture until the complete consumption of the starting materials, monitored by TLC. After evaporation of the solvent, the resulting precipitate was washed with H2O; it did not require any further purification.Reference Example 20 To a suspension of 2, 3-dichloroquinoxaline (300 mg, 1.51 mmol) in methanol (15 mL) and N, N-dimethylformamide (1.0 mL) was added sodium methoxide (28percent in methanol, 309 mg, 1.66 mmol) dropwise at 0 General procedure: A mixture of a 3-substituted-2-chloroquinoxaline 2(1 mmol), a secondary amine (3 mmol), Pd(PPh3)2Cl2 (0.05 mmol, 0.036 g), CuI (0.1 mmol, 0.019 g), sodium dodecyl sulfate (0.1 mmol, 0.029 g), and K2CO3 (3 mmol, 0.414 g) was stirred in H2O (5 mL) at room temperature under an argon atmosphere. Propargyl alcohol(1.2 mmol, 0.067 g) was then added, and the resulting mixture was stirred at 80 C for 18 h. After completion of the reaction, the mixture was filtered, and the resulting solid was washed with H2O and dried. The crude product was purified by column chromatography (silica gel 100) using CHCl3-CH3OH (99:1) as the eluent.

Molecular Weight:194.62
XLogP3:2.5
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:194.0246905
Monoisotopic Mass:194.0246905
Topological Polar Surface Area:35
Heavy Atom Count:13
Complexity:179
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes