 Home > Encyclopedia > 5-Bromo-2-ethoxypyridine

5-Bromo-2-ethoxypyridine

5-Bromo-2-ethoxypyridine structure

CAS No:
55849-30-4
Formula:
C7H8BrNO
Chemical Name:
5-Bromo-2-ethoxypyridine
Synonyms:
Pyridine,5-bromo-2-ethoxy-;5-Bromo-2-ethoxypyridine;3-Bromo-6-ethoxypyridine;6-Ethoxypyridin-3-yl bromide
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Request for Quotation

Description

Light yellow Cryst

5-Bromo-2-ethoxypyridine Basic Attributes

Molecular Weight：

202.05

Exact Mass：

202.05

DSSTox ID：

DTXSID50355774

HScode：

2933399090

Characteristics

PSA：

22.1

XLogP3：

2.2

Appearance：

Off-white to pale yellow Solid

Density：

1.5±0.1 g/cm3

Melting Point：

25 °C @ Solvent: Ethyl acetate

Boiling Point：

107°C/33mmHg(lit.)

Flash Point：

218 °F

Refractive Index：

1.534

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-37/38-41

safety instructions：

26-36/39

Marks：

Xn,Xi

Hazard note：

Harmful

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302-H315-H317-H318-H335

GHS Classification：

|Danger|H302 (97.73%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P333+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

5-Bromo-2-ethoxypyridine Use and Manufacturing

Freshly cut sodium (74 mg, 3.2 mmol) was dissolved in ethanol (1.2 ml) followed by addition of 2, 5-dibromopyridine (236 mg, lmmol) in DMF (3 ml). The mixture was stirred for Ih at 8OA solution of freshly prepared sodium ethoxide (sodium, 4.9 g, 210 mmol; absolute ethanol, 100 mL, room temperature) was treated with 2, 5-dibromopyridine (10 g, 42 mmol) and was heated at reflux for 18 h. After cooling to room temperature, the mixture was poured into aqueous saturated sodium bicarbonate solution, was extracted with diethyl ether, and the ether layer was washed with brine, was dried over magnesium sulfate, was concentrated in vacuo. Purification by silica gel chromatography (100:1 hexanes-ethyl acetate) gave 7.5 g (88percent yield) of the title compound. A solution of freshly prepared sodium ethoxide (sodium, 4.9g, 210 mmol; absolute ethanol, 100 mL, room temperature) was treated with 2, 5-dibromopyridine (10g, 42 mmol) and was heated at reflux for 18 hours. After cooling to room temperature, the mixture was poured into aqueous saturated sodium bicarbonate solution, was extracted with diethyl ether, and the ether layer was washed with brine, was dried over magnesium sulfate, was concentrated in vacuo. Purification by silica gel chromatography (100:1 hexanes-ethyl acetate) gave 7.5 g (88percent yield) of the title compound. General procedure: An oven-dried Schlenk tube was charged with Pd(OAc)2 (0.015 mmol, 3.4 mg), X-Phos (0.015 mmol, 7.2 mg), Cs2CO3 (0.9 mmol, 293 mg), substrate 1 (0.3 mmol) and 2 (0.4 mmol). The reaction vessel was evacuated and backfilled again with nitrogen gas, and 1, 4-dioxane (1 mL) was added via syringe under nitrogen. The reaction mixture was stirred at 100 C for 12 hours. The reaction mixture was then cooled to room temperature and diluted with EtOAc. The crude was nextfiltered through a plug of celite, which was washed with ethyl acetate. The solution was concentrated and further purifiedby flash column chromatography to afford the corresponding product.Freshly cut sodium (74 mg, 3.2 mmol) was dissolved in ethanol (1.2 ml) followed by addition of 2, 5-dibromopyridine (236 mg, lmmol) in DMF (3 ml). The mixture was stirred for Ih at 8O0C, and cooled to rt. The reaction was quenched with water (4 mL) and extracted with ether three times. The combined organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash column chromatography to afford the target product as a white solid (192 mg, 95%). MS (m/z) (M~+H): 202, 204.

Computed Properties

Molecular Weight:202.05
XLogP3:2.2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:200.97893
Monoisotopic Mass:200.97893
Topological Polar Surface Area:22.1
Heavy Atom Count:10
Complexity:99.6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 5-Bromo-2-ethoxypyridine

shanghai jinghui industrial co.ltd Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of Fluorine containing fine chemicals Pharmaceutical

5-Bromo-2-ethoxypyridine 99% colorless liquid JINGHUI

CAS No.: 55849-30-4

Content: 99%

Inquiry
Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

5-Bromo-2-ethoxypyridine 99%

CAS No.: 55849-30-4

Content: 99%

Inquiry
Changzhou Xuanming Pharmaceutical Techno Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Peptides,Chemicals,API,Additives

High Purity 5-Bromo-2-ethoxypyridine 55849-30-4

CAS No.: 55849-30-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high quality 5-Bromo-2-ethoxypyridine 99% transparent liquid KANBEI

CAS No.: 55849-30-4

Grade: Industrial Grade

Content: 99%

Inquiry