5-bromo-4-(trifluoromethyl)pyrimidin-2-amine

To a solution of 2-amino-4-trifluoromethylpyrimidine (25 g, 0.15 mol) in CHTo a solution of 2-amino-4-trifluoromethylpyrimidine (25 g, 0.15 mol) in CHMethod 9; Synthesis of 5-bromo-4-(trifluoromethyl)pyrimidin-2-amine; [0249] To a solution of 2-amino-4-trifluoromethylpyrimidine (8.0 g, 49.1 mmol) in chloroform (300 mL) was added N-bromosuccinimide (8.9 g, 50 mmol). The solution was stirred in the dark for 16 hours, at which time additional N-bromosuccinimide (4.0 g, 22.5 mmol) was added. After stirring for an additional 4 hours the solution was added toCH[0250] To a solution of 2-amino-4-trifluoromethylpyrimidine (8.0 g, 49.1 mmol) in chloroform (300 mL) was added N-bromosuccinimide (8.9 g, 50 mmol). The solution was stirred in the dark for 16 hours, at which time additional N-bromosuccinimide (4.0 g, 22.5 mmol) was added. After stirring for an additional 4 hours the solution was added to CH2CI2 (200 mL) and IN NaOH (200 mL). Upon mixing, the layers were separated and [0092] Synthesis -bromo-4-(trifluoromethyl)pyrimidin-2-amine[0093] To a solution of 2-amino-4-trifluoromethylpyrimidine (8.0 g, 49.1 mmol) in chloroform (300 mL) was added N-bromosuccinimide (8.9 g, 50 mmol). The solution was stirred in the dark for 16 hours, at which time additional N-bromosuccinimide (4.0 g, 22.5 mmol) was added. After stirring for an additional 4 hours the solution was added to CH4-(Trifluoromethyl)pyrimidin-2-ylamine (2 g, 12.3 mmol) was suspended in chloroform (70 ml) followed by the addition of N-bromosuccinimide (3.3 g, 18.4 mmol) and the resulting mixture was stirred at 50° C. for 5 hours and then at room temperature for 15 hours. A mixture of methylene chloride (50 ml) and 1 M sodium hydroxide (50 ml) was added, the resulting mixture was stirred, and then the organic layer was fractionated and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound (2.2 g, 75percent) as a pale orange solid.To a solution of compound 31(500mg, 3.06 mmol) in DCM (60 mL) was added NBS (1.66g, 9.32 mmol). The solution was stirred in the dark for 2d at rt. Then the reaction was quenched with iN NaOH (50 mL) and extracted with DCM (50 mL). The organic phase was washed with brine (100 mL), dried over Na2SO4, filtered and concentrated to give the title compound 32 as a white solid (530 mg, 73percent yield), which was used directly in the next step without further purification. ‘H NIVIR (CDC13): 8.52(s, 1H), 5.29(bs, 2H).

Molecular Weight:242.00
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Exact Mass:240.94624
Monoisotopic Mass:240.94624
Topological Polar Surface Area:51.8
Heavy Atom Count:12
Complexity:163
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes