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2-Amino-3-benzyloxypyridine

2-Amino-3-benzyloxypyridine structure

CAS No:
24016-03-3
Formula:
C12H12N2O
Chemical Name:
2-Amino-3-benzyloxypyridine
Synonyms:
2-Pyridinamine,3-(phenylmethoxy)-;Pyridine,2-amino-3-(benzyloxy)-;3-(Phenylmethoxy)-2-pyridinamine;2-Amino-3-benzyloxypyridine;3-Benzyloxy-2-aminopyridine;[(3-(Benzyloxy)pyridin-2-yl])amine;3-Benzyloxypyridin-2-amine;NSC 298538;2-Amino-3-(benzoxy)pyridine
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

Brown crystalline powder

2-Amino-3-benzyloxypyridine Basic Attributes

Molecular Weight：

200.24

Exact Mass：

200.24

BRN：

392674

EC Number：

245-983-9

UNII：

IYW7T7718Z

NSC Number：

298538

DSSTox ID：

DTXSID50178748

HScode：

29221985

Characteristics

PSA：

48.1

XLogP3：

Appearance：

Green to brown Crystalline Powder

Density：

1.2±0.1 g/cm3

Melting Point：

89-91 °C @ Solvent: Ethanol

Boiling Point：

361.8°C at 760 mmHg

Flash Point：

172.6±23.7 °C

Refractive Index：

1.622

Storage Conditions：

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Vapor Pressure：

2.02E-05mmHg at 25°C

Safety Information

Transport codes：

UN2811

wgk germany：

hazard class code：

36/37/38-20/21/22

safety instructions：

26-37/39-24/25-36/37/39-22,26-36

Marks：

Xi,Xn

Hazard note：

Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2-Amino-3-benzyloxypyridine Use and Manufacturing

Methods of Manufacturing

temperature below 40 ° C, to the 300L stainless steel reactor 48L of purified water was added slowly stirring 48kg sodium hydroxide, stirring until dissolved.To sodium hydroxide solution followed by adding 16kg 2-amino-3-hydroxypyridine, 1.6kg tetrabutylammonium bromide, 17.92L benzyl chloride, plus warming to 70 ~ 75 ° C reaction 6 hours, stirring was stopped, Let stand, liquid separation; aqueous phase extraction with toluene (20Lx3);Purified water washing (30Lx2), the organic phase was collected, concentrated to a large amount of solid precipitation, temperature 0 ~ 5 ° C, crystallization was stirred for 2 hours, centrifuged, The filter cake was rinsed with 3.2 L of pre-cooled toluene and dried under vacuum at 50~55 ° C. for 3 hours to afford Intermediate II as a bright yellow solid, 22.5 kg of 2-amino-3-benzyloxypyridine, with a molar yield of 77.3percent , Purity 99.53percent.2-Amino-3-hydroxypyridine (11 g, 100 mmol), chlorobenzyl (12.66 mL, 110 mmol) and tetrabutylammonium bromide (3 g, 10 mmol) were dissolved in 50 mL of 40percent sodium hydroxide solution and 50 mL of dichloromethane The mixture was stirred at room temperature for 19 h. After the reaction is completed, liquid is dispensed, The aqueous phase is diluted with water and extracted three times with dichloromethane. Combine the organic phase, Drying with anhydrous sodium sulfate, Filter and concentrate, Column chromatography of the residue gave the title compound as a brown solid (12 g, 60percent yield).

Uses

2-Amino-3-benzyloxypyridine is used in preparation of pyridinyl/pyridazinyloxymethyl substituted Raf kinase inhibitors.

Computed Properties

Molecular Weight:200.24
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:200.094963011
Monoisotopic Mass:200.094963011
Topological Polar Surface Area:48.1
Heavy Atom Count:15
Complexity:181
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2-Amino-3-benzyloxypyridine

Shandong Ranhang Biotechnology Co., Ltd. Contact Supplier

CN
3 YRS

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2-Amino-3-benzyloxypyridine 24016-03-3

CAS No.: 24016-03-3

Content: 99.5%

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Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
4 YRS

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2-Amino-3-benzyloxypyridine 99%

CAS No.: 24016-03-3

Content: 99%

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Guide of 2-Amino-3-benzyloxypyridine

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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2-Amino-3-benzyloxypyridine

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