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Promegestone

Promegestone structure

CAS No:
34184-77-5
Formula:
C22H30O2
Chemical Name:
Promegestone
Synonyms:
Estra-4,9-dien-3-one,17-methyl-17-(1-oxopropyl)-,(17β)-;Estra-4,9-dien-3-one,17α-methyl-17-propionyl-;(17β)-17-Methyl-17-(1-oxopropyl)estra-4,9-dien-3-one;17,21-Dimethyl-19-nor-4,9-pregnadiene-3,20-dione;R 5020;Promegestone;RU 5020;U 56217;Surgestone;51922-93-1;1050678-85-7
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

ChEBI: A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.

Promegestone is a progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group. It has a role as a progestin, a progesterone receptor agonist and an antineoplastic agent. It is a 3-oxo-Delta(4) steroid and a 20-oxo steroid. It derives from a hydride of an estrane.|A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.

Promegestone Basic Attributes

Molecular Weight：

326.47

Exact Mass：

326.47

UNII：

9XE0V2SQYX

DSSTox ID：

DTXSID4036510

ATC Code：

G - Genito urinary system and sex hormones

Characteristics

PSA：

34.1

XLogP3：

5.17780

Density：

1.09 g/cm3

Melting Point：

512 °C

Boiling Point：

486.8ºC at 760 mmHg

Flash Point：

180.4ºC

Refractive Index：

1.553

Specific rotation：

D20 -262° (c = 0.5 in ethanol)

Safety Information

Precautionary statement(s)：

P201, P202, P281, P308+P313, P405, P501

Hazard Statements：

H340

GHS Classification：

|Danger|H340 (97.44%): May cause genetic defects [Danger Germ cell mutagenicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

17,21-Dimethyl-19-nor-4,9-pregnadiene-3,20-dione

Promegestone Use and Manufacturing

As radioligand for the progestin receptor.

Computed Properties

Molecular Weight:326.5
XLogP3:3.3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:326.224580195
Monoisotopic Mass:326.224580195
Topological Polar Surface Area:34.1
Heavy Atom Count:24
Complexity:668
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes