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Clofoctol

Clofoctol structure

CAS No:
37693-01-9
Formula:
C21H26Cl2O
Chemical Name:
Clofoctol
Synonyms:
Phenol,2-[(2,4-dichlorophenyl)methyl]-4-(1,1,3,3-tetramethylbutyl)-;2-[(2,4-Dichlorophenyl)methyl]-4-(1,1,3,3-tetramethylbutyl)phenol;2-(2,4-Dichlorobenzyl)-4-(1,1,3,3-tetramethylbutyl)phenol;2-(2,4-Dichlorobenzyl)-4-(2,4,4-trimethyl-2-pentyl)phenol;Clofoctol;Octofene;2-[(2,4-Dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol
Categories:
Analytical Chemistry > Standard

Description

Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. It is only functional against Gram-positive bacteria, It penetrates into human lung tissue.

2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol is a diarylmethane.|Clofoctol is a bacteriostatic antibiotic with activity against Gram-positive bacteria. Clofoctol is used in the treatment of upper and lower respiratory tract infections.

Clofoctol Basic Attributes

Molecular Weight：

365.34

Exact Mass：

365.34

EC Number：

253-632-6

UNII：

704083NI0R

NSC Number：

758389

DSSTox ID：

DTXSID5045889

NCI Thesaurus Code：

C78048

ATC Code：

J - Antiinfectives for systemic use

Characteristics

PSA：

20.2

XLogP3：

7.00360

Density：

1.127 g/cm3

Melting Point：

78 °C

Boiling Point：

447.7ºC at 760 mmHg

Flash Point：

160.4ºC

Refractive Index：

1.555

Storage Conditions：

2-8°C

Toxicity：

LD50 orally in male rats: >4 g/kg (Debat)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

SL0533000

GHS Classification：

H413 (100%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]|P273, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

clofoctol

Clofoctol Use and Manufacturing

antibacterial

Computed Properties

Molecular Weight:365.3
XLogP3:8.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:5
Exact Mass:364.1360708
Monoisotopic Mass:364.1360708
Topological Polar Surface Area:20.2
Heavy Atom Count:24
Complexity:401
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes