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Carazolol

Carazolol structure

CAS No:
57775-29-8
Formula:
C18H22N2O2
Chemical Name:
Carazolol
Synonyms:
2-Propanol,1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]-;1-(9H-Carbazol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol;Carazolol;BM 51052;Suacron Praemix;Suacron;(±)-Carazolol;DL-Carazolol;(R,S)-Carazolol;Racemic Carazolol;Conducton;1-((9H-Carbazol-4-yl)oxy)-3-(isopropylamino)propan-2-ol;69207-57-4
Categories:
Analytical Chemistry > Standard

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Description

Yellowish solid

Carazolol is a member of carbazoles.

Carazolol Basic Attributes

Molecular Weight：

298.38

Exact Mass：

298.38

EC Number：

260-945-1

HScode：

2933990090

Characteristics

PSA：

57.28000

XLogP3：

3.59

Appearance：

Yellowish solid

Density：

1.2±0.1 g/cm3

Melting Point：

133-137 °C

Boiling Point：

531.2±40.0 °C at 760 mmHg

Flash Point：

275.1±27.3 °C

Refractive Index：

1.652

Collision Cross Section：

165.5 Å² [M+H]+ [CCS Type: TW]|173.98 Å² [M-H]-

Safety Information

Hazard category：

6.1

Transport codes：

2811

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

RTECS Number：

UA8685000

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (97.44%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)

MeSH Entry Terms：

BM 51052

Carazolol Use and Manufacturing

Methods of Manufacturing

4-(2, 3-Epoxypropyloxy)carbazole is prepared by reacting 4-hydroxycarbazole with 3-chloro-1, 2-epoxypropane, and then reacting with isopropylamine to obtain carbazolol.

Uses

Carazolol is a high-affinity, lipophilic, non-selective ligand of the β-adrenergic receptors (Kis = 0.114 and 0.4 nM for β2- and β3-adrenoceptors, respectively). It acts as a receptor antagonist (beta blocker) or inverse agonist for β1 and β2 receptors but functions as an agonist at the β3-adrenergic receptor.

Use Classification：

Veterinary Drug -> -> JECFA Functional Classesbeta-ADRENOCEPTOR_BLOCKING_AGENT -> -> JECFA Functional Classes|Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

Food Additive Classes：

Veterinary Drug -> beta-ADRENOCEPTOR_BLOCKING_AGENT ->

Computed Properties

Molecular Weight:298.4
XLogP3:3.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:298.168127949
Monoisotopic Mass:298.168127949
Topological Polar Surface Area:57.3
Heavy Atom Count:22
Complexity:350
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Epichlorohydrin