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Droxinostat

Droxinostat structure

CAS No:
99873-43-5
Formula:
C11H14ClNO3
Chemical Name:
Droxinostat
Synonyms:
Droxinostat;4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide;NS 41080;ButanaMide, 4-(4-chloro-2-Methylphenoxy)-N-hydroxy-
Categories:
Biochemical Engineering > Inhibitors

Description

Droxinostat(NS41080) is a selective inhibitor of HDAC3, HDAC6, and HDAC8 with IC50 of 16.9, 2.47 and 1.46 μM, respectively; > 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.IC50 Value: 16.9 μM(HDAC3); 2.47 μM(HDAC6); 1.46 μM(HDAC8)Target: HDAC3/6/8in vitro: Droxinostat is originally identified as a sensitizer of PPC-1 cells to FAS and TRAIL by downregulating the expression of c-Fas-associated death domain-like interleukin-1-converting enzyme-like inhibit

4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide is an aromatic ether.

Droxinostat Basic Attributes

Molecular Weight：

243.68676

Exact Mass：

243.06600

DSSTox ID：

DTXSID20340899

Characteristics

PSA：

58.6

XLogP3：

2.8

Appearance：

white to off-white

Density：

1.252 g/cm3

Water Solubility：

DMSO: ≥20mg/mL

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-37/38-41

safety instructions：

26-39

Marks：

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302-H315-H318-H335

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide

Droxinostat Use and Manufacturing

Droxinostat is a histone deacetylase selective inhibitor and is used in cancer therapy and cancer research. Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8.

Computed Properties

Molecular Weight:243.68
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:243.0662210
Monoisotopic Mass:243.0662210
Topological Polar Surface Area:58.6
Heavy Atom Count:16
Complexity:225
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Droxinostat

CAS No.: 99873-43-5

Content: 0.98%

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