Fenpropi-morph

ChEBI: A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a 3-(p-tert-butylphenyl)-2-methylpropyl group.

4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine is a member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a 3-(p-tert-butylphenyl)-2-methylpropyl group.

In the Vilsmeier reaction, dimethylformamide is used as the solvent. Phosphorus oxychloride is added to the solvent at 20°C, the temperature is increased, 4-tert-butylacetophenone is added dropwise at 70～80°C, the reaction is 5h, and the reaction is completed. % Sodium hydroxide is treated to obtain 96% 4-tert-butylphenyl-1-chloro-2-methacrylaldehyde. Reduction reaction 4-tert-butylphenyl-1-chloro-2-methacrolein is hydrogenated and reduced under palladium/carbon catalysis to produce 4-tert-butylphenyl isobutyraldehyde. The synthesis of fenmorpholine 4-tert-butylphenyl isobutyraldehyde reacts with 2, 6-dimethylmorpholine to synthesize fenmorpholine.

Morpholine fungicides have protective, therapeutic and systemic effects. The sterol reduction inhibitor can be used for powdery mildew, smut, rust, cotton wilt and cereal smut of cereal crops, beans and sugar beets. The recommended dose is 7.5g active ingredient/100m2.

Molecular Weight:303.5
XLogP3:5.2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:303.256214676
Monoisotopic Mass:303.256214676
Topological Polar Surface Area:12.5
Heavy Atom Count:22
Complexity:317
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes