1,3-Propanedisulfonic acid
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1,3-Propanedisulfonic acid
structure -
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CAS No:
21668-77-9
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Formula:
C3H8O6S2
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Chemical Name:
1,3-Propanedisulfonic acid
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Synonyms:
1,3-Propanedisulfonic acid;Eprodisate
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CAS No:
Description
Eprodisate is a new compound designed to interfere with interactions between amyloidogenic proteins and glycosaminoglycans and thereby inhibit polymerization of amyloid fibrils and deposition of the fibrils in tissues[1]. Eprodisate slow the progression of AA amyloidosis-related renal disease and has possible applicability to other types of amyloidosis[2].
Eprodisate slows the decline of renal function in AA amyloidosis.
Safety Information
III
8
3265
3
36/37/38-34-20/21/22
26-36-45-36/37/39-27
Xi,C
P280-P305 + P351 + P338-P310
H302 + H312 + H332-H314
Drug Information
Investigated for use/treatment in amyloidosis.
Decline in renal function associated with Amyloid A (AA) amyloidosis can be slowed by eprodisate (Kiacta), a drug that inhibits the deposit of the complex protein in tissues. AA amyloidosis is a serious, frequently fatal disorder involving deposits of amyloid fibrils in various organs and tissues. It is a complication of many chronic inflammatory disorders, but little is known about its etiology or natural history. Eprodisate delays the progression of AA amyloidosis-associated renal disease.
eprodisate
1,3-Propanedisulfonic acid Use and Manufacturing
Treatment of secondary (AA) amyloidosis.
Human drugs -> Rare disease (orphan)
Computed Properties
Molecular Weight:204.2
XLogP3:-1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:203.97623032
Monoisotopic Mass:203.97623032
Topological Polar Surface Area:126
Heavy Atom Count:11
Complexity:254
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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