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Tinoridine

Tinoridine structure

CAS No:
24237-54-5
Formula:
C17H20N2O2S
Chemical Name:
Tinoridine
Synonyms:
Thieno[2,3-c]pyridine-3-carboxylic acid,2-amino-4,5,6,7-tetrahydro-6-(phenylmethyl)-,ethyl ester;Thieno[2,3-c]pyridine-3-carboxylic acid,2-amino-6-benzyl-4,5,6,7-tetrahydro-,ethyl ester;2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine;2-Amino-3-ethoxycarboxyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine;2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,4-tetrahydrothieno[2,3-c]pyridine;Y 3642;Tinoridine;NSC 158555;2-Amino-6-benzyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Tinoridine is a thienopyridine.|Tinoridine is under investigation in clinical trial NCT01224756 (Efficacy of Tinoridine in Treating Pain and Inflammation in Adults).

Tinoridine Basic Attributes

Molecular Weight：

317.40596

Exact Mass：

316.42

EC Number：

246-102-0

UNII：

C9Z9ICZ7YR

NSC Number：

158555

DSSTox ID：

DTXSID9023677

HScode：

2934999090

Characteristics

PSA：

83.8

XLogP3：

3.58440

Density：

1.256 g/cm3

Melting Point：

112.5 °C

Boiling Point：

493.5ºC at 760 mmHg

Flash Point：

252.3ºC

Vapor Pressure：

7E-10mmHg at 25°C

Toxicity：

LD50 in mice, rats (mg/kg): 5400, >10200 orally; 1600, 1250 i.p. (Nakanishi, 1970)

Safety Information

Hazard category：

IRRITANT

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

2-amino-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)-pyridine-3-carboxylic acid ethyl ester

Computed Properties

Molecular Weight:316.4
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:316.12454906
Monoisotopic Mass:316.12454906
Topological Polar Surface Area:83.8
Heavy Atom Count:22
Complexity:387
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes