5-Iodo-3-nitro-2-pyridinamine

A 250 ml three-necked flask was charged with 2-amino-3-nitropyridine (10.0 g, 72.0 mmol), Acetic acid (44 mL) and water (10 mL).90 when addedPeriodic acid (3.28 g, 14.4 mmol)And the mass percentage concentration of 98percent concentrated sulfuric acid(1.3 mL); after stirring for 10 minutes, iodine (9.1 g, 36.0 mmol), Continue stirring at this temperature for 60 minutes. After cooling to room temperature, The reaction solution was added to a saturated aqueous solution of sodium thiosulfate (100 mL); separated by filtration, The solid was washed with saturated brine (50 mL x 2) and petroleum ether (50 mL x 2).The crude product was recrystallized from a mixture of petroleum ether and ethyl acetate (volume ratio: 5: 1)A yellow solid, high purity compound 1 (17.57 g, 69.1 mmol, 96percent) was obtained.a) 5-Iodo-3-nitropyridin-2-amineTo a solution of 3-nitropyridin-2-amine (1.2 g, 8.63 mmol) in acetic acid (5 ml), water (1 ml) and sulfuric acid (0.2 ml) was added periodic acid (0.4 g, 1.72 mmol, 0.2 eq.) and the mixture was stirred at 90 °C for 15 min. Iodine (0.87 g, 3.45 mmol, 0.4 eq.) was added portionwise and the mixture was heated at 90 °C for 1 h. The mixture was quenched by the addition of water and extracted with ethylacetate (3 To a solution of 3-nitropyridin-2-amine (1.2 g, 8.63 mmol) in acetic acid (5 ml), water (1 ml) and sulfuric acid (0.2 ml) was added periodic acid (0.4 g, 1.72 mmol, 0.2 eq.) and the mixture was stirred at 90° C. for 15 min. 5-Iodo-3-nitro-2-aminopyridine

Molecular Weight:265.01
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Exact Mass:264.93482
Monoisotopic Mass:264.93482
Topological Polar Surface Area:84.7
Heavy Atom Count:11
Complexity:160
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes