5-Bromo-7-nitro-1H-indazole

Starting material 20a (1.00 g, 4.32 mmol) was dissolved in 15 mL of AcOH.An aqueous solution (2 mL) of sodium nitrite (0.66 mg, 9.52 mmol) was added at 0 °C.After the addition, rt was stirred for 6 hours.The TLC monitors the reaction of the starting material completely, spins the reaction solution, extracts, and the crude product is purified by column chromatography.An orange powder compound 20b (0.5 mg, 2.07 mmol) was obtained in a yield: 47.7percent.Starting material 10 (1.00 g, 4.32 mmol) was dissolved in 15 mL of AcOH. An aqueous solution (2 mL) of sodium nitrite (0.66 mg, 9.52 mmol) was added at 0 °C. After the addition, rt was stirred for 6 hours. TLC monitors the reaction of the starting material completely, spins the reaction solution, and extracts. The crude product was purified by column chromatography. Obtained an orange powder compound 2 (0.5 mg, 2.07 mmol), Yield: 47.7percent.

Molecular Weight:242.03
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:240.94869
Monoisotopic Mass:240.94869
Topological Polar Surface Area:74.5
Heavy Atom Count:13
Complexity:220
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes