2-Chloro-4-nitrobenzenemethanol
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2-Chloro-4-nitrobenzenemethanol
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CAS No:
52301-88-9
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Formula:
C7H6ClNO3
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Chemical Name:
2-Chloro-4-nitrobenzenemethanol
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Synonyms:
Benzenemethanol,2-chloro-4-nitro-;Benzyl alcohol,2-chloro-4-nitro-;2-Chloro-4-nitrobenzenemethanol;p-Nitro-6-chlorobenzyl alcohol;2-Chloro-4-nitrobenzyl alcohol;(2-Chloro-4-nitrophenyl)methanol
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CAS No:
2-Chloro-4-nitrobenzenemethanol Basic Attributes
187.58044
187.58
257-828-2
DTXSID10200332
2906299090
Safety Information
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
2-Chloro-4-nitrobenzenemethanol Use and Manufacturing
In a 250 mL round bottom flask, methyl 2-chloro-4-nitrobenzoate (5 g, 23 mmol) was dissolved in anhydrous dichloromethane (100 mL). The solution was cooled to -78°C under nitrogen. Bis(2-methylpropyl)alumane (35 mL, 35mmol, 1 M in hexane) was added dropwise. The mixture was stirred at -78°C for 4 hours and quenched by addition of water (5 mL). The resulting mixture was warmed up to room temperature in 20 minutes. Naλ/, iV'-Carbonyldiimidazole (19.91 g, 122 mmol) is added batchwise to 2-chloro-4- nitrobenzoic acid (25 g, 90 percent purity, 111 mmol) in anhydrous THF (420 mL) at RT and stirred for 1 h. At 15 - 20 Starting with acid 52: a solution of 2-chloro-4-nitrobenzoic acid (15.95 g, 79 mmol, 1.0 equiv.) in THF (200 mL) was cooled to 0 Starting with acid chloride 51: 2-chloro-4-nitrobenzoylchloride 51 (6.22 g, 28.3 mmol, 1.0 equiv.) can be reduced by using NaBH
Computed Properties
Molecular Weight:187.58
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:187.0036207
Monoisotopic Mass:187.0036207
Topological Polar Surface Area:66
Heavy Atom Count:12
Complexity:171
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2-Chloro-4-nitrobenzenemethanol
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Business licensed Certified factoryManufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acidInquiryCAS No.: 52301-88-9Grade: Industrial GradeContent: 95%
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