3,4,5-Trichlorophenol

197.45

197.45

210-183-0

2JF54EGE7O

243667

2020

DTXSID4026212

Needles from ligroin

2908199090

20.2

4.01

3,4,5-trichlorophenol appears as needles (from ligroin) or off-white solid. (NTP, 1992)

1.6±0.1 g/cm3

101 °C

275 °C

123.9±25.9 °C

1.609

Sol in ether; slightly sol in water

0-6°C

pKa= 7.84

As a group, the chlorophenols are characterized by an odor which has been described as unpleasant, medicinal, pungent, phenolic, strong, or persistent. /Chlorinated phenols/

Insoluble in water.

Phenols and Cresols

3,4,5-TRICHLOROPHENOL may be incompatible with acid chlorides, acid anhydrides and oxidizing agents. (NTP, 1992).

UN30779/PG3

3

20/21/22-36/37/38-50/53-41-37/38

26-36-61-60

SN1650000

Xn,N

Stable. Probably combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides.

P261-P273-P280-P305 + P351 + P338-P501

H302 + H312 + H332-H315-H318-H335-H410

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced. /Trichlorophenols/

Nat'l Research Council Canada; Chlorinated Phenols (1982) NRCC No. 18578.|Scientific Criteria Document For Standard Development. Chlorinated Phenols In The Aquatic Environment No. 2-84 (1984).|Environmental Protection Service. Chlorophenols and Their Impurities in the Canadian Environment Report EPS 3-EC-81-2 (1981).|USEPA; Reviews of the Environmental Effects of Pollutants: XI. Chlorophenols (1979) EPA 600/1-79-012.|For more Special Reports (Complete) data for 3,4,5-TRICHLOROPHENOL (6 total), please visit the HSDB record page.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

|Danger|H302+H312+H332 (92.68%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P362, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 42 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical under ambient temperatures, and keep it away from oxidizing materials. (NTP, 1992)

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Non combustible /Trichlorophenol/

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn, or burns with difficulty. /Trichlorophenol/

Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner. /Trichlorophenol/|Environmental considerations: Water spill: Use natural deep water pockets, excavated lagoons, or sand bag barriers to trap material at bottom. If dissolved, apply activated carbon at ten times the spilled amount in region of 10 ppm or greater concentration. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /Trichlorophenol/|ACTIVATED CARBON IS A GOOD METHOD FOR REMOVING CHLOROPHENOLS FROM WATER. COMPETITIVE ADSORPTION OCCURS BETWEEN CHLOROPHENOLS & HUMIC SUBSTANCES PRESENT IN NEARLY ALL MUNICIPAL WATER SUPPLIES. THIS COMPETITION DECR THE CAPACITY OF CARBON FOR CHLOROPHENOLS. /CHLOROPHENOLS/

If material not on fire and not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary. /Trichlorophenol/|Personnel protection: Avoid breathing vapors. Keep upwind or dusts. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Trichlorophenol/

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Chlorophenols, liquid; Chlorophenols, solid/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Chlorophenols, liquid; Chlorophenols, solid/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Chlorophenols, liquid; Chlorophenols, solid/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Chlorophenols, liquid; Chlorophenols, solid/|For more DOT Emergency Guidelines (Complete) data for 3,4,5-TRICHLOROPHENOL (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

TRICHLOROPHENOLS ... PRODUCE REDNESS & EDEMA ON SKIN CONTACT & ON PROLONGED EXPOSURE EVEN MILD TO MODERATE CHEMICAL BURNS ON SKIN OF MAN. IN THE EYE THEY INDUCE CONJUNCTIVAL IRRITATION & SOMETIMES CORNEAL INJURY & IRITIS. DUSTS ARE IRRITATING TO NOSE & PHARYNX. /TRICHLOROPHENOLS/

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Chlorophenols is produced, as an intermediate or final product, by process units covered under this subpart. /Chlorophenols/

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

F027; Discarded unused formulations containing tri-, tetra-, or pentachlorophenol or discarded unused formulations containing compounds derived from these chlorophenols are classified as a hazardous waste from a nonspecific source and must be managed according to Federal and/or State hazardous waste regulations. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (see 40 CFR 261.5).

Biologically treated effluent samples from 9 Canadian bleached softwood kraft mills were analyzed for chlorinated phenolic content. Chlorinated phenolics, including 3,4,5-trichlorophenol, present in effluent discharged from bleached kraft mills are not expected to contribute an off-odor to recipient waters.|3,4,5-Trichlorophenol was detected in the effluent of a sewage treatment plant in the UK at concns of 0.17-7.23 ug/l(1). 3,4,5-Trichlorophenol was detected in the effluent of a metal reclamation facility at a concn of 0.1 ug/cu m(2). 3,4,5-Trichlorophenol was identified, not quantified, in the effluent of pulp mills in Canada(3).

3,4,5-Trichlorophenol was detected in sludge samples in the UK at concns of 0.07-1.52 mg/kg(1). 3,4,5-Trichlorophenol was identified, not quantified, in sediment from Lake Ladoga, Russia(2). 3,4,5-Trichlorophenol was detected in the sediment from a brook in Finland at concns of less than 1 ng/g to 177 ng/g(3). 3,4,5-Trichlorophenol was detected in soil at three wood-preserving facilities in Finland at concns ranging from less than 0.1 to 8.1 mg/kg dry wt(4) and in soil within the area of two sawmills in Finland at concns of 0.003-0.092 mg/kg fresh wt(5). 3,4,5-Trichlorophenol was detected in sediment from the Weser Estuary (Germany) at a concn of 0.434 mg/kg wet wt and 0.050-0.330 mg/kg wet wt in suspended matter(6). 3,4,5-Trichlorophenol was detected in sediment taken from Lake Ketelmeer (The Netherlands), 17 samples, 82% pos., max concn 19 ug/kg dry wt, median concn 1.2 ug/L(4) and in sediments taken from 19 other sites in The Netherlands, <0.02-1.7 mg/kg dry wt(7).

3,4,5-Trichlorophenol was detected at concns of less than 0.2 ug/cu m in urban air in Germany(1).

Trichlorophenols /including 3,4,5-trichlorophenol/ are known to occur naturally in the environment, in aquatic plants, ... and in raw domestic sewage.

Chlorophenols may be produced inadvertently by chlorination reactions which take place during the disinfection of wastewater effluents or drinking water sources. Chlorinated phenols represent important compounds with regard to potential point source and non-point source water contamination. /Chlorinated phenols/|3,4,5-Trichlorophenol may form in the environment as the result of the degradation of pentachlorophenol or 2,3,4,5-tetrachlorophenol(1,2). 3,4,5-Trichlorophenol may also be released in emission from some municipal incinerators(3). This compound may also be released to the environment as a result of the chlorination of phenol-containing wastewater or drinking water and from the bleaching process in pulp and paper mills(4).

TERRESTRIAL FATE: Based on a pKa of 7.8(1), 3,4,5-trichlorophenol is expected to dissociate somewhat in moist soil surfaces(SRC). Based on a recommended classification scheme(2), a Koc value of 2,900(3), measured in marine sediment, indicates that 3,4,5-trichlorophenol is expected to have low mobility in soil, but the mobility of the anion is expected to be greater than that of the neutral species(4). Volatilization of 3,4,5-trichlorophenol is not expected from moist soil surfaces(SRC) given a Henry's Law constant of 2.3X10-7 atm-cu determined from a fragment constant estimation method(5). 3,4,5-Trichlorophenol is not expected to volatilize from dry soil surfaces given its vapor pressure of 0.002 mm Hg at 25 °C(6,SRC). This compound was biodegraded 17% in a clay loam soil over a 160 day incubation period(7).|AQUATIC FATE: Based on a pKa of 7.8(1), 3,4,5-trichlorophenol is expected to dissociate somewhat in aquatic systems. Based on a recommended classification scheme(2), a Koc value of 2,900(3), measured in marine sediment, indicates that 3,4,5-trichlorophenol is expected to adsorb to suspended solids and sediment in water(SRC). 3,4,5-Trichlorophenol is expected to volatilize slowly from water surfaces(4,SRC) based on the esetimated Henry's Law constant of 2.3X10-7 atm-cu m/mole(SRC), determined from a fragment constant estimation method(5). Estimated volatilization half-lives of 3,4,5-trichlorophenol for a model river and model lake are 127 and 927 days, respectively(4,SRC). According to a classification scheme(6), the potential for bioconcentration in aquatic organisms is considered high based upon a BCF value of 650(4,SRC) determined from a log Kow of 4.01(7). 3,4,5-Trichlorophenol was biodegraded in anaerobic estuarine sediment with a biodegradation half-life of about 22 days(8).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 3,4,5-trichlorophenol, which has an estimated vapor pressure of 0.002 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 3,4,5-trichlorophenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 3 days(3,SRC).

As a chemical class, the phenols are susceptible to photooxidations in sunlit natural water via reactions with peroxy and hydroxyl radicals(1); half-lives for phenol are on the order of 0.8 days of sunlight for peroxy radicals and 100 hours of sunlight for hydroxyl radicals(1); half-lives for the trichlorophenols can be expected to be slower due to the halogen substitutions, but may still have some importance with respect to overall environmental degradation(SRC).|The rate constant for the vapor-phase reaction of 3,4,5-trichlorophenol with photochemically-produced hydroxyl radicals is 2.1X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 3 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). A pKa value of 7.8(2) indicates that 3,4,5-trichlorophenol will dissociate somewhat to 3,4,5-trichlorophenolate in moist soils and water(SRC).

A BCF value of 650 was calculated for 3,4,5-trichlorophenol(SRC), using a log Kow of 4.01(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is high(SRC).

3.63e+03 L/kg|Based on a recommended classification scheme(1), a Koc value of 2,900 measured in marine sediment(2), indicates that 3,4,5-trichlorophenol is expected to have slight mobility in soil surfaces. Based on a pKa value of 7.8(3), 3,4,5-trichlorophenol is expected to dissociate somewhat in moist soil surfaces and the mobility of the anion is expected to be greater than that of the neutral species(4).

In water, 3,4,5-trichlorophenol is expected to dissociate somewhat to 3,4,5-trichlorophenolate based on a pKa value of 7.8(1). The Henry's Law constant for 3,4,5-trichlorophenol is estimated as 2.3X10-7 atm-cu m/mole(SRC), determined from a fragment constant estimation method(2). This value indicates that 3,4,5-trichlorophenol will volatilize slowly from water surfaces(3,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 127 days(4,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 927 days(3,SRC). 3,4,5-Trichlorophenol's Henry's Law constant indicates that volatilization from moist soil surfaces is not expected. 3,4,5-Trichlorophenol is not expected to volatilize from dry soil surfaces(SRC) based on an estimated vapor pressure of 0.002 mm Hg at 25 °C(4,SRC).

SURFACE WATER: 3,4,5-Trichlorophenol was detected in the Rhine River at Lobith (The Netherlands) during 1976, 52 samples 6% pos, max concn 0.07 ug/l and during 1977, 52 samples, 29% pos, max concn 0.37 ug/l(1). 3,4,5-Trichlorophenol was detected in the Ijssel River near Kampen (The Netherlands) between March 1979 and March 1980, 13 samples, 54% pos, max concn 0.31 ug/l(2). 3,4,5-Trichlorophenol was detected at concns of less than 1 ng/l to 306 ng/l in a brook in Finland(3). 3,4,5-Trichlorophenol was identified, not quantified, in Lake Ladoga, Russia(4).|GROUNDWATER: 3,4,5-Trichlorophenol was detected at a median concn of 0.07 ug/l and a maximum concn of 0.34 ug/l(1).

... Exposure for humans is through the food chain, as a result of the ingestion by grazing animals of the chlorophenoxy acid herbicides 2,4,5-T or Silvex (2-(2,4,5-trichlorophenoxy) propionic acid).|Trichlorophenols can occur in tap water as a result of standard chlorination treatment(1). Therefore, the general population may be exposed to 3,4,5-trichlorophenol through oral consumption or dermal contact with chlorinated tap water(SRC).

The compounds are absorbed from the gastroenteric tract and from parenteral sites of injection. /Chlorophenols/

CHLORINATED PHENOLS ... ARE VERY EFFECTIVE (... IN VITRO) AS UNCOUPLERS OF OXIDATIVE PHOSPHORYLATION. THEY THUS PREVENT INCORPORATION OF INORGANIC PHOSPHATE INTO ATP WITHOUT EFFECTING ELECTRON TRANSPORT. AS A RESULT OF THIS ACTION, WHICH IS BELIEVED TO OCCUR @ MITOCHONDRIAL /MEMBRANE/, CELLS CONTINUE TO RESPIRE BUT SOON ARE DEPLETED OF ATP NECESSARY FOR GROWTH. /CHLOROPHENOLS/|A set of reference compounds was used in attempts to identify compounds that act by specific chemical mechanism to disturb the spindle function in cell line V79. Among compounds that are particularly active in relation to their lipophilic character are some chlorophenols, caffeine, diamide, diethylmaleate, 1-chloro-2,4-dinitrobenzene and tert-butylhydroperoxide. This points to Ca-sequestering by mitochondria and/or cellular pH regulation (chlorophenols), Ca release and sequestering by the endoplasmic reticulum (caffeine), enzymic conjugation to GSH (diethylmaleate, chlorodinitrobenzene) and hydroperoxide metabolism (tert-butylhydroperoxide) as important target functions for specific activity. /Chlorophenols/

POLYCHLORINATED DIBENZOFURANS WERE IDENTIFIED IN COMMERCIAL CHLOROPHENOL FORMULATIONS. 2,4,6-TRICHLOROPHENATE SHOWED 1,2,4,6,8,9-HEXA-, 1,2,3,4,6,8-HEXA-, 1,2,4,6,7,8-HEXA-, & 1,2,4,6,8-PENTACHLORODIBENZOFURAN. /CHLOROPHENOL/|CONTAMINATION WITH 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; 2,7-DICHLORODIBENZO-P-DIOXIN; 1,3,6,8-TETRACHLORODIBENZO-P-DIOXIN; AND PENTACHLORODIBENZO-P-DIOXIN AT LEVELS OF 0.07 TO 6.2 PPM.

SYMPTOMS: Symptoms of exposure to this compound may include redness and edema on skin contact. In the eyes, it induces conjunctival irritation, corneal injury and iritis. It may also cause irritation of the nose and pharynx. ACUTE/CHRONIC HAZARDS: This compound is an irritant of the skin, eyes, nose and throat. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Phenols are very toxic poisons AND corrosive and irritating, so that inducing vomiting may make medical problems worse. IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

For advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W TKO /SRP: To keep open, "minimal flow rate"/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam (Valium). ... Use proparacaine hydrochloride to assist eye irrigation ... . /Phenols and related compounds/|For basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Administer activated charcoal ... . Dilution may be contraindicated because it may increase absorption. Do not use emetics ... . Cover skin burns with dry, sterile dressings after decontamination ... . Maintain body temperature. /Phenols and related compounds/

TRICHLOROPHENOLS ... PRODUCE REDNESS & EDEMA ON SKIN CONTACT & ON PROLONGED EXPOSURE EVEN MILD TO MODERATE CHEMICAL BURNS OF SKIN OF MAN. IN EYE THEY INDUCE CONJUNCTIVAL IRRITATION & SOMETIMES CORNEAL INJURY & IRITIS. DUSTS ARE IRRITATING TO NOSE & PHARYNX. SYSTEMIC EFFECTS ... PRESUMABLY RESEMBLE ... PHENOL ... . /TRICHLOROPHENOLS/|Symptoms and pulmonary function were evaluated in 7 subjects exposed to trichlorophenol. Symptoms from upper airways and chest were more common among exposed than in control subjects (60% and 10%). Significantly reduced forced expiratory flow at 75% of vital capacity and incr closing vol were measured, while other spirometric variables and the transfer factor of the lung for carbon monoxide were normal. Incr elastic recoil pressure of the lung and x-ray signs of lung tissue involvement were noticed in 2 subjects. The findings suggest an irritating effect on the lung of trichlorophenol, and it cannot be excluded that long-term exposure may produce pulmonary fibrosis. /Trichlorophenols/|Adverse health effects have been seen in workers exposed to chlorophenols contaminated with 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) or to products synthesized from trichlorophenol. These effects, probably due to TCDD, include persistent chloracne, liver dysfunction, neuromuscular weakness, porphyria, and psychological changes. /Chlorophenols/|ALL /TRICHLOROPHENOLS/ ARE LESS TOXIC THAN SIMPLE PHENOL. /TRICHLOROPHENOLS/

3,4,5-TCP

/Trichlorophenols exist/ as 6 isomers (2,4,5-; 3,4,5-; 2,4,6-; 2,3,4-; 2,3,5- and 2,3,6-) ... .

Determination in water: Methylene chloride extraction followed by gas chromatography with flame ionization or electron capture detection or gas chromatography plus mass spectrometry. /Trichlorophenols/|TRACE DETERMINATION OF PHENOLIC COMPOUNDS IN WATER BY REVERSED PHASE LIQUID CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION. 1 PPB LEVELS WERE DETECTED. /PHENOLIC COMPOUNDS/|GAS CHROMATOGRAPHIC ANALYSIS OF TRACE PHENOLS BY DIRECT ACETYLATION IN AQUEOUS SOLUTION. /PHENOLS/|CHLOROPHENOLIC POLLUTANTS DETERMINED BY HIGH PRESSURE LIQ CHROMATOGRAPHY. /CHLOROPHENOLIC POLLUTANTS/|For more Analytic Laboratory Methods (Complete) data for 3,4,5-TRICHLOROPHENOL (6 total), please visit the HSDB record page.

GAS CHROMATOGRAPHIC DETERMINATION OF PHENOLIC COMPOUNDS, INCLUDING 2,6-DICHLOROPHENOL, IN URINE OF INDUSTRIALLY EXPOSED WORKERS. THE DETECTION LIMITS IN URINE RANGE FROM 0.1 MG/L URINE FOR PHENOL TO 1 MG/L FOR THE DI- & TRICHLOROPHENOLS. /TRICHLOROPHENOLS/|CHLORINATED PHENOLS IN URINE ARE ISOLATED BY SORPTION ONTO SMALL COLUMN OF MACRORETICULAR RESIN. THE PHENOLS WERE ELUTED FROM COLUMN WITH 2-PROPANOL IN HEXANE; SOLN CONCENTRATED & THE PHENOLS WERE SEPARATED & ANALYZED BY GC. /CHLORINATED PHENOLS/|A METHOD IS DESCRIBED FOR THE CONFIRMATION OF CHLOROPHENOLS IN HYDROLYZED URINE (HUMAN) USING GAS CHROMATOGRAPHY & LIQ CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION. /CHLOROPHENOLS/|BLOOD SERUM FROM 58 FEMALES FROM DADE COUNTY, FL WERE ANALYZED FOR PRESENCE OF 2,4-DICHLOROPHENOL & OTHER PHENOLIC COMPOUNDS BY GLC. DRINKING WATER USAGE PATTERNS WERE MAINTAINED FOR 5 YR; 33 DRANK MUNICIPAL CHLORINATED WATER WHILE REMAINING GENERALLY USED NON-CHLORINATED WELL WATER. FAUCET SAMPLES FROM 12 OF THE CHLORINATED & 10 FROM NON-CHLORINATED DRINKING WATER SUPPLIES & 10 SAMPLES OF ADIPOSE TISSUE FROM AUTOPSIES WERE ALSO ANALYZED. NO 2,4-DICHLOROPHENOL WAS FOUND. TRICHLOROPHENOL WAS DETECTED IN WATER & BIOLOGICAL TISSUES. /PHENOLIC CMPD/|For more Clinical Laboratory Methods (Complete) data for 3,4,5-TRICHLOROPHENOL (6 total), please visit the HSDB record page.