(2-BROMOBENZYL)METHYLAMINE

Part A. Example 47 Part A. A solution of 2-bromobenzylbromide (9 g, 36.1 mmol) in [MEOH] (60 [ML)] was added dropwise over 30 min. to a solution of methylamine in [MEOH] (200 [ML] of a 2.0 M solution, 0.4 mol). The resulting solution was stirred at rt for 2h and concentrated. The residue obtained was dissolved in DCM (100 mL) and successively washed with saturated aqueous sodium carbonate, dried over sodium sulphate, and concentrated. The resulting oil was distilled to afford the title compound (7g, 95percent) as a colorless oil (b. p. [110°C] at 0.1 mm Hg, [LC/MS] retention time = 1.22 min.; [M+ =] 201.92, Column: Phenominex 4.6mm x [50MM.] Solvent A = 10percent [MEOH, ] 90percent H2O, lOmM NH4Ac; Solvent B = 90percent [MEOH, ] 10percent [H20, ] lOnM NH4Ac, Flow rate: 4 mL/min, Gradient: 0percent B-100percent B 4 min.).EXAMPLE

Molecular Weight:200.08
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:198.99966
Monoisotopic Mass:198.99966
Topological Polar Surface Area:12
Heavy Atom Count:10
Complexity:95.3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes