Hexylamine

101.19

101.19

1731298

203-851-8

CI4E002ZV8

1443

2590

2734|2924

DTXSID3021930

Water-white liquid|Colorless liquid

29211980

26

1.52/2.34

Clear colorless to slightly yellow Liquid

0.77 g/cm³

-22.9 °C

131-132 °C

27 °C

n 20/D 1.418(lit.)

H2O: 14 g/L (20 ºC)

Flammables area

Vapour pressure, kPa at 20°C: 0.87

Relative vapour density (air = 1): 3.5

Oral-Rat LD50: 670 mg/kg

Inflammable in case of open flame, high temperature, oxidant; burning produces toxic nitrogen oxide fumes

2.1-9.3%(V)

Fishy aroma

pH of 1% w/v aqueous solution was 12.9 at 30 °C

2.68e-05 atm-m3/mole|Henry's Law constant = 2.68X10-5 atm-cu m/mole at 25 °C

pKa of the conjugate acid (C6H13-NH3+) = 10.64 at 25 °C|pKb = 3.44 at 25 °C

In water solution, all of the simple alkyl amines share the property of forming ammonium ions; this is due to the ability of the free electron pair on the amine nitrogen to pick up a proton from water and form a hydroxide ion raising the solution pH.|Hydroxyl radical reaction rate constant = 3.7X10-11 cu-cm/molc sec at 25 °C (est)

Highly flammable. Slightly soluble in water.

Amines, Phosphines, and Pyridines

Highly Flammable

HEXYLAMINE neutralize acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

-3.998X10+9 J/kmol

Lower flammable limit: 2.1% by volume; Upper flammable limit: 9.3% by volume

36.54 kJ/mol (at boiling pt); 45.10 kJ/mol at 25 °C

Citical temperature: 592.3 K. critical pressure: 3.4 MPa

II

8

UN 2734 8/PG 1

1

10-21/22-35-20/21/22-51/53

26-36/37/39-45-16-61

MQ4540000

C,F,Xi,N

The warehouse is ventilated, low temperature and dry; stored separately from oxidants and acids

Irritant/Flammable/Corrosive/Air Sensitive

Stable. Incompatible with acids, acid anhydrides, acid chlorides, carbon dioxide, strong oxidizing agents.

P273-P280-P301 + P310-P305 + P351 + P338-P310

H226-H301 + H311-H314-H411

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.|Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product

Vapors may form explosive mixture with air.|Incompatible materials: Acids, Acid chlorides, Acid anhydrides, Strong oxidizing agents, Carbon dioxide (CO2).

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)|Flammable. Gives off irritating or toxic fumes (or gases) in a fire. Above 29 °C explosive vapour/air mixtures may be formed.|Flammable - 3rd degree

|Danger|H226 (99.62%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P264, P270, P273, P280, P301+P310, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P361, P363, P370+P378, P391, P403+P235, P405, and P501|Aggregated GHS information provided by 264 companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P264, P270, P273, P280, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P361, P363, P370+P378, P391, P403+P235, P405, and P501

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: Fully encapsulating, vapor-protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material and transfer to containers (except for Hydrazine). Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. (ERG, 2016)|Eye/face protection: Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).|Skin protection: Handle with gloves.|Body Protection: Complete suit protecting against chemicals. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.|Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Dangerous fire hazard when exposed to heat or flame ... .|Flammable.

Vapors may form explosive mixture with air.|Upper explosion limit: 9.3 %(V); Lower explosion limit: 2.1 %(V).

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical, or carbon dioxide.|Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.|Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.

Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx).

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

It material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock-down vapors.|Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.|Do not eat, drink, or smoke during work.|Use ventilation, local exhaust or breathing protection.|For more Preventive Measures (Complete) data for 1-Hexylamine (11 total), please visit the HSDB record page.

Hexylamine is a moderate to severe irritant for the skin, eyes, and mucous membranes.

Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Wash away remainder with plenty of water. Do NOT wash away into sewer.

Fireproof. Separated from strong oxidants and strong acids.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema. The effects may be delayed. Medical observation is indicated.

NO open flames, NO sparks and NO smoking. Above 29 °C use a closed system, ventilation and explosion-proof electrical equipment.

PREVENT GENERATION OF MISTS! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Gasoline and diesel fueled engine exhaust from automobiles was analyzed for aliphatic amines (including hexylamine) and total amine emission was less than 1 ug/km(1).

SOIL: Hexylamine was qualitatively detected in volatile distillates (100 °C) collected from a loam soil collected from the Moscow region of Russia that was not under cultivation(1).

Hexylamine has reportedly been identified in tobacco(1) and tobacco smoke(1-3).

moderately toxic

IDENTIFICATION AND USE: Hexylamine is used in organic syntheses. HUMAN STUDIES: Hexylamine is a moderate to severe irritant for the skin, eyes, and mucous membranes. ANIMAL STUDIES: Hexylamine was a severe skin irritant when tested in rabbits for 24 hr. Hexylamine in the concentration of 144.9 ug/mL without metabolic activation and 640.9 ug/mL with metabolic activation does not cause genetic chromosome aberrations when Chinese hamster lung cells are exposed for 6 and 24 hr.

The effect of mersalyl on the relaxation of catch by various monoamines was studied in the anterior byssal retractor muscle of Mytilus. As has already been reported, mersalyl blocked the relaxing response to indoleamines but not block that to catecholamines. The relaxations in response to catecholamine-related compounds (dopa, octopamine, tyramine, phenylephrine, beta-phenylethylamine and phenylethanolamine) and hexylamine were, however, antagonized more or less effectively with mersalyl. It was suggested that the catecholamine-related compounds and hexylamine can act on relaxing nerve endings to increase neurotransmitter serotonin in the junctional clefts, and mersalyl antagonizes the relaxation in response to these compounds by blocking the serotonin.

LD50 Rabbit dermal 318.48 mg/kg bw|LD50 Rat (male) oral 670 mg/kg

Hexylamine has been identified in Latakia tobacco leaf voltiiles(1) and in obnoxious plant smells created by volatile amines from hogweed, cow parsnip (Heracleum sphondylium), bear's-foot (Helleborus foetidus), cuckoopint (Arum Maculatum) and hawhorn (Crataegus oxyacantha)(2).

Hexylamine's production and use in organic syntheses(1) and as a flavor/odor additive in foods(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 147(SRC), determined from a structure estimation method(2), indicates that hexylamine is expected to have high mobility in soil(SRC). The pKa of hexylamine (conjugate acid) is 10.64(3), indicating that this compound will exist almost entirely in cation form in the environment at pH 4-8 and mostly to partially in cation form at pH 8-10 and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of cationic hexylamine from moist soil surfaces is not expected to be an important fate process since cations do not volatilize(SRC). Volatilization of neutral hexylamine from moist soil surfaces may occur given a measured Henry's Law constant of 2.68X10-5 atm-cu m/mole(5). Hexylamine is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 7.95 mm Hg at 20 °C(6). Most primary amines, including hexylamine, are considered to be readily biodegradable(7). The analogous compounds pentylamine and hexanediamine, present at 100 mg/L, reached 75 and 55% of their theoretical BOD in 2 and 3 weeks, respectively, using an activated sludge inoculum at 30 mg/L in the Japanese MITI test which classified both as readily biodegradable(8).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 147(SRC), determined from a structure estimation method(2), indicates that hexylamine is not expected to adsorb to suspended solids and sediment(SRC). The pKa of hexylamine (conjugate acid) is 10.64(3), indicating that this compound will exist almost entirely in cation form in the environment at pH 4-8 and mostly to partially in cation form at pH 8-10. Volatilization of cationic hexylamine from water surfaces is not expected to be an important fate process since cations do not volatilize(SRC). Volatilization of neutral hexylamine from water surfaces is expected(4) based upon a measured Henry's Law constant of 2.68X10-5 atm-cu m/mole at 25 °C(5). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 1.5 and 14 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 11(SRC), from its log Kow of 2.06(7) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Most primary amines, including hexylamine, are considered to be readily biodegradable(8). The analogous compounds pentylamine and hexanediamine, present at 100 mg/L, reached 75 and 55% of their theoretical BOD in 2 and 3 weeks, respectively, using an activated sludge inoculum at 30 mg/L in the Japanese MITI test which classified both as readily biodegradable(9). Aliphatic amines are considered stable to hydrolysis, as the molecules do not contain any functional group sensitive to hydrolysis(8).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hexylamine, which has a vapor pressure of 7.95 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Gas-phase hexylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 10.3 hours(SRC), calculated from its rate constant of 3.7X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Hexylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of hexylamine with photochemically-produced hydroxyl radicals has been estimated as 3.7X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 10.3 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Aliphatic amines are considered stable to hydrolysis, as the molecules do not contain any functional group sensitive to hydrolysis(2). The rate constant for the estimated OH radical reaction of hexylamine with hydroxyl radicals in aqueous solutions at pH 1 is 1.3X10+10 L/mol-sec(3); this corresponds to an aquatic half-life of 62 days at an aquatic concentration of 1X10-17 hydroxyl radicals per liter(4). Hexylamine does not contain chromophores that absorb at wavelengths >290 nm(2) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 11 was calculated in fish for hexylamine(SRC), using a log Kow of 2.06(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of hexylamine can be estimated to be 147(SRC). According to a classification scheme(2), this estimated Koc value suggests that hexylamine is expected to have high mobility in soil. The pKa of hexylamine is 10.64(3), indicating that this compound will exist almost entirely to partially in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

The pKa of hexylamine (conjugate acid) is 10.64 at 25 °C(1). The dissociation curve of hexylamine in water indicates the compound will exist almost entirely in cation form at pH values of 1 to 8, but partially in the neutral form at pH 8 to 10(2). Volatilization of cationic hexylamine from water surfaces is not expected to be an important fate process since cations do not volatilize(SRC). The Henry's Law constant for neutral hexylamine has been measured as 2.68X10-5 atm-cu m/mole at 25 °C in dilute aqueous solution(3); cationic hexylamine increases the pH of the water solution (1% hexylamine solution increases the pH to 12.9)(4). This Henry's Law constant indicates that neutral hexylamine is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(5) is estimated as 1.5 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(5) is estimated as 14 days(SRC). Hexylamine's Henry's Law constant indicates that volatilization of the neutral form from moist soil surfaces may occur(SRC). Hexylamine is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 7.95 mm Hg at 20 °C(4).

Hexylamine was detected in beer distillates(1) and 24 Italian cheeses(2). Hexylamine has use as odor and/or flavor additive in cereal, cheese, dairy, fish, fruit and meat(3). Food categories include baked goods, breakfast cereals, cheese, condiments, relishes, confection, frosting, fats, oils, fish products, frozen dairy, fruit ices, gravies, meat products, milk products, grains, poultry, processed fruits, seasonings, flavors snack foods and soups; maximum reported food use concentration is 10 ppm(3).

Occupational exposure to hexylamine may occur through inhalation and dermal contact with this compound at workplaces where hexylamine is produced or used. Monitoring and use data indicate that the general population may be exposed to hexylamine via inhalation of ambient air near various plants that emit volatile hexylamine, inhalation of tobacco smoke, and ingestion of food. (SRC)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. (ERG, 2016)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Keep victim calm and warm. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. (ERG, 2016)

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen ... . Treat seizures with diazepam (Valuim) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/Amines and related compounds/

/SIGNS AND SYMPTOMS/ Hexylamine is a moderate to severe irritant for the skin, eyes, and mucous membranes.|/ALTERNATIVE and IN VITRO TESTS/ Exposure to organic solvents may cause narcotic effects. At the cellular level, these narcotic effects have been associated with a reduction in neuronal excitability caused by changes in membrane structure and function. In order to critically test whether changes in membrane geometry contribute to these narcotic effects, cultured human SH-SY5Y neuroblastoma cells have been exposed to selected organic solvents. The solvent-induced changes in cell membrane capacitance were investigated using the whole-cell patch clamp technique for real-time capacitance measurements. Exposure of SH-SY5Y cells to the cyclic hydrocarbons m-xylene, toluene, and cyclohexane caused a rapid and reversible increase of membrane capacitance. The aliphatic, nonpolar n-hexane did not cause a detectable change of whole-cell membrane capacitance, whereas the amphiphiles n-hexanol and n-hexylamine caused an increase of membrane capacitance and a concomitant reduction in membrane resistance. Despite a large difference in dielectric properties, the chlorinated hydrocarbons 1,1,2,2-tetrachoroethane and tetrachloroethylene caused a similar magnitude increase in membrane capacitance. The theory on membrane capacitance has been applied to deduce changes in membrane geometry caused by solvent partitioning. Although classical observations have shown that solvents increase the membrane capacitance per unit area of membrane, i.e., increase membrane thickness, the present results demonstrate that solvent partitioning predominantly leads to an increase in membrane surface area and to a lesser degree to an increase in membrane thickness. Moreover, the present results indicate that the physicochemical properties of each solvent are important determinants for its specific effects on membrane geometry. This implies that the hypothesis that solvent partitioning is associated with a common perturbation of membrane structure needs to be revisited and cannot account for the commonly observed /CNS depressant/ effects of different organic solvents.

hexylamine

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Burning sensation. Cough. Sore throat. Laboured breathing. Shortness of breath. Symptoms may be delayed.

Redness. Pain. Skin burns.

Redness. Pain. Severe deep burns.

1-Hexanamine: ACTIVE

Food additives -> Flavoring Agents|Flavoring Agents -> JECFA Flavorings Index|Fire Hazards -> Flammable - 3rd degree

Flavoring Agents