 Home > Encyclopedia > Serotonin

Serotonin

Serotonin structure

CAS No:
50-67-9
Formula:
C10H12N2O
Chemical Name:
Serotonin
Synonyms:
1H-Indol-5-ol,3-(2-aminoethyl)-;Indol-5-ol,3-(2-aminoethyl)-;3-(2-Aminoethyl)-1H-indol-5-ol;5-HT;3-(β-Aminoethyl)-5-hydroxyindole;3-(2-Aminoethyl)indol-5-ol;DS substance;Enteramine;5-HTA;5-Hydroxy-3-(β-aminoethyl)indole;5-Hydroxytryptamine;Serotonin;Substance DS;Thrombocytin;Thrombotonin;Tryptamine,5-hydroxy-;Enteramin;5-Hydroxyltryptamine;5-Hydroxytriptamine;33361-47-6
Categories:
Analytical Chemistry > Standard

Description

ChEBI: A primary amino compound that is the 5-hydroxy derivative of tryptamine.

Solid

Serotonin is a primary amino compound that is the 5-hydroxy derivative of tryptamine. It has a role as a human metabolite, a mouse metabolite and a neurotransmitter. It is a monoamine molecular messenger, a primary amino compound, a member of phenols, a member of hydroxyindoles and a member of tryptamines. It derives from a tryptamine. It is a conjugate base of a serotonin(1+).|For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product.|A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.

Serotonin Basic Attributes

Molecular Weight：

176.22

Exact Mass：

176.22

EC Number：

200-058-9

UNII：

333DO1RDJY

DSSTox ID：

DTXSID8075330

HScode：

2933990090

Characteristics

PSA：

XLogP3：

0.21

Appearance：

Solid

Density：

1.011 g/mL at 25 °C(lit.)

Melting Point：

167.5 °C

Boiling Point：

211-212 °C(lit.)

Flash Point：

205 °F

Refractive Index：

n20/D 1.538(lit.)

Water Solubility：

H2O: 0.5 g/100 mL (25 ºC)

Storage Conditions：

2-8°C

Toxicity：

Subcutaneous-rat LD50: 285 mg/kg; oral-mouse LD50: 60 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Collision Cross Section：

135.85 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|151.9 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|150.8 Å² [M+Na]+ [CCS Type: DT, Method: stepped-field]|146.9 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|147.1 Å² [M-H]-

Safety Information

Packing level：

Hazard category：

IRRITANT

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

63-25

safety instructions：

36/37-45

RTECS Number：

NM2450000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P201, P202, P264, P270, P281, P301+P310, P308+P313, P321, P330, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P310, P308+P313, P321, P330, P405, and P501|Aggregated GHS information provided by 128 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)

Metabolism/Metabolites：

Serotonin has known human metabolites that include (2S,3S,4S,5R)-6-[[3-(2-Aminoethyl)-1H-indol-5-yl]oxy]-3,4,5-trihydroxy-2-oxanecarboxylic acid and 3-Ethyl-1H-indol-5-ol.

MeSH Entry Terms：

3-(2-Aminoethyl)-1H-indol-5-ol

Serotonin Use and Manufacturing

neurotransmitter

Computed Properties

Molecular Weight:176.21
XLogP3:0.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:176.094963011
Monoisotopic Mass:176.094963011
Topological Polar Surface Area:62
Heavy Atom Count:13
Complexity:174
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Serotonin

Guangzhou Yaoguang Technology Co., Ltd. Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Custom Synthetic Chemicals,Biological Stains,Pharmaceutical Intermediates,Cosmetic Grade Chemicals,Enzyme,Nucleosides,Indicators,Speciality Chemicals,Biological Chemicals,Enzyme Substrates

50-67-9

CAS No.: 50-67-9

Inquiry