N-TERT-BUTYL-ALPHA-PHENYLNITRONE
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N-TERT-BUTYL-ALPHA-PHENYLNITRONE
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CAS No:
3376-24-7
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Formula:
C11H15NO
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Chemical Name:
N-TERT-BUTYL-ALPHA-PHENYLNITRONE
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Synonyms:
c-phenyl-n-tert-butylnitrone;n-tert-butyl-2-phenylnitrone;n-tert-butyl-alpha-phenyl-nitron;n-tert-butyl-c-phenylnitrone;(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide;PHENYL N-TERT-BUTYLNITRONE;N-BENZYLIDENE-TERT-BUTYLAMINE N-OXIDE;N-T-BUTYL-ALPHA-PHENYLNITRONE
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CAS No:
Description
white to light beige fine crystalline powder
Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Crystallise PBN from hexane. It is a free radical trap. [cf Janzen Methods Enzymology 105 188 1984, Beilstein 7 IV 519.]
N-TERT-BUTYL-ALPHA-PHENYLNITRONE Basic Attributes
177.24
177.24
2044028
222-168-6
TSCA listed
DTXSID8040648
white
2929 90 00
Characteristics
28.8
2.93750
white powder
0.990
73-74 °C(lit.)
283℃
119℃
1.5480 (estimate)
Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml).
2-8°C
1.50±0.53(Predicted)
Store at <= 20°C.
Drug Information
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)
alpha phenyl-tert-butyl nitrone
N-TERT-BUTYL-ALPHA-PHENYLNITRONE Use and Manufacturing
Spin trap reagent for carbon- or oxygen- or nitrogen-centered free radicals.
N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
N-tert-Butyl-α-phenylnitrone has been used:as a component of Dneasy Blood&Tissue buffer to preserve the oxidized state of DNA extracted from human non-tumorigenic epithelial breast (MCF10A) cellsas a free radical scavenger of reactive oxygen species (ROS) in microglial (MG) cell linesto attenuate fibroblast senescence in unstable oral squamous cell carcinomas (GU-OSCC)
2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide: INACTIVE
Computed Properties
Molecular Weight:177.24
XLogP3:1.3
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:177.115364102
Monoisotopic Mass:177.115364102
Topological Polar Surface Area:28.8
Heavy Atom Count:13
Complexity:185
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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N-TERT-BUTYL-ALPHA-PHENYLNITRONE
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