Diisopropylamine

101.19

101.19

605284

203-558-5

BR9JLI40NO

0449

6758

1158

DTXSID9025085

Colorless liquid ...

2921199020

12

1.64

Clear colorless Liquid

0.7169 g/cm³ @ Temp: 20 °C

-61 °C

84 °C @ Press: 760 Torr

1.4 °F

n20/D 1.392(lit.)

H2O: 100 g/L (20 ºC)

Store at RT.

50 mm Hg ( 20 °C)

3.5 (vs air)

Oral-mouse LD50: 2120 mg/kg; inhalation-rat LC50: 4800 mg/m3/2 hours

Inflammable in case of open flame, high temperature, oxidant; burning produces toxic nitrogen oxide fumes

vol% in air: 0.8.1

... Ammonia or fish-like odor.

Strongly alkaline

pKa: 11.07 (in water) at 25 °C|pKb = 3.43 at 20 °C

1 ppm equals 4.14 mg/cu m|RATIO OF SPECIFIC HEAT OF VAPOR (GAS): (EST) 1.064|HEAT OF SOLN: -76 CAL/G|Heat of formation = -1.5x10+8 J/kmol|For more Other Experimental Properties (Complete) data for DIISOPROPYLAMINE (6 total), please visit the HSDB record page.

Highly flammable. Soluble in water. Sensitive to heat and air.

Amines, Phosphines, and Pyridines

Highly Flammable

DIISOPROPYLAMINE can react violently with oxidizing agents and strong acids. Readily eutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

600 °F (USCG, 1999)|600 °F (316 °C)|316 °C

-11000 CAL/G

7.73 eV

Lower flammable limit: 1.1% by volume; Upper flammable limit: 7.1% by volume|Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.

The vapour is heavier than air and may travel along the ground; distant ignition possible.

MAY ATTACK SOME FORMS OF PLASTIC

8.265 kcal/mole @ 25 °C

CRITICAL TEMP: 249.0 °C; CRITICAL PRESSURE: 30 ATM

II

3

UN 1158 3/PG 2

2

11-20/22-34

16-26-36/37/39-45

IM4025000

F,C

The warehouse is ventilated, low temperature and dry; stored separately from oxidants and acids

VOLATILE

P210-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P403 + P233

H225-H302-H314-H331

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|DIISOPROPYLAMINE MAY BE DISPOSED OF BY ATOMIZING IN A SUITABLE COMBUSTION CHAMBER EQUIPPED WITH AN APPROPRIATE EFFLUENT GAS CLEANING DEVICE.

Strong oxidizers, strong acids.

Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fires. Behavior in Fire: Vapor is heavier than air and may travel to a source of ignition and flash back. (USCG, 1999)|Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire. Vapour/air mixtures are explosive. Risk of fire and explosion on contact with strong oxidizing agents.|Flammable - 3rd degree

|Danger|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P330, P363, P370+P378, P403+P235, P405, and P501|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P311, P312, P321, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 511 companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P273, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P310, P311, P321, P330, P363, P370+P378, P391, P403+P233, P403+P235, P405, and P501|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P309+P311, P310, P311, P321, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: Fully encapsulating, vapor-protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material and transfer to containers (except for Hydrazine). Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: If concentration is >5%, wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet should be immediately removed due to its flammability hazard(i.e. for liquids with flash point Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. Provide: Eyewash fountains should be provided (when concentration is >5%) in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. (NIOSH, 2016)|AIR-SUPPLIED MASK; PLASTIC GLOVES; MONOGOGGLES; RUBBER APRON|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact (>5%).|Eyewash fountains should be provided in areas where there is any possbility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. />5%/|For more Personal Protective Equipment (PPE) (Complete) data for DIISOPROPYLAMINE (8 total), please visit the HSDB record page.|(See protection codes)

Flammable; severe fire hazard

83.5-84% BY VOL IN AIR @ 743 MM HG|Vapor may explode if ignited in an enclosed area.|Explosive limits , vol% in air: 0.8-7.1

Use dry chemical, "alcohol resistant" foam, carbon dioxide, or water spray. Water may be ineffective. Use water spray to keep fire-exposed containers cool. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products.|Use dry chemical, alcohol foam or carbon dioxide fire fighting agents. Water may be ineffective, but effective to keep fire-exposed containers cool, to disperse the vapors, to flush spills away from exposures, to dilute spills to nonflammable mixtures and thus to prevent the spread of fires. Wear complete protective clothing.

Vapors are heavier than air and may travel to a source of ignition and flash back.

1. REMOVE ALL IGNITION SOURCES. 2. VENTILATE AREA OF SPILL OR LEAK. 3. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN SAFE PLACE (SUCH AS FUME HOOD). ALLOW SUFFICIENT TIME FOR EVAPORATING VAPORS TO COMPLETELY CLEAR HOOD DUCTWORK. BURN PAPER IN SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS. LARGE QUANTITIES CAN BE RECLAIMED OR COLLECTED AND ATOMIZED IN A SUITABLE COMBUSTION CHAMBER EQUIPPED WITH AN APPROPRIATE EFFLUENT GAS CLEANING DEVICE.|DIISOPROPYLAMINE SHOULD NOT BE ALLOWED TO ENTER A CONFINED SPACE, SUCH AS A SEWER, BECAUSE OF THE POSSIBILITY OF AN EXPLOSION. SEWERS DESIGNED TO PRECLUDE THE FORMATION OF EXPLOSIVE CONCN OF...VAPORS ARE PERMITTED.|Eliminate all ignition sources. Stop or control the leak, if this can be done without undue risk. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Absorb in noncombustible material for proper disposal.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|The worker should immediately wash the skin when it becomes contaminated.|For more Preventive Measures (Complete) data for DIISOPROPYLAMINE (6 total), please visit the HSDB record page.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.|/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.|/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.|For more DOT Emergency Guidelines (Complete) data for DIISOPROPYLAMINE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Diisopropylamine vapor is a respiratory irritant and a severe eye irritant.|A skin and severe eye irritant.

Permissible Exposure Limit: Table Z-1 8-hr Time-Weighted Avg: 5 ppm (20 mg/cu m). Skin Designation.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 ppm (20 mg/cu m), skin.

Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Cover the spilled material with inert absorbent or sand. Then store and dispose of according to local regulations. Do NOT wash away into sewer.

Fireproof. Separated from strong oxidants, strong acids and food and feedstuffs. Store only in original container. Store in an area without drain or sewer access.

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Contact of the vapour with the eyes may cause visual disturbances. Exposure could cause asphyxiation due to swelling in the throat. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest.

Repeated or prolonged contact with skin may cause dermatitis.

NO open flames, NO sparks and NO smoking. NO contact with strong oxidizing agents. Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding).

PREVENT GENERATION OF MISTS! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Diisopropylamine was qualitatively identified in soil samples taken from the region of Moscow(1).

moderately

LD50 Mouse oral 2,120 mg/kg|LD50 Rabbit oral 4,700 mg/kg|LD50 Rat oral 770 mg/kg|LD50 Guinea pig oral 2800 mg/kg|For more Non-Human Toxicity Values (Complete) data for DIISOPROPYLAMINE (6 total), please visit the HSDB record page.

In persons with impaired pulmonary function, expecially those with obstructive airway diseases, the breathing of diisopropylamine might cause exacerbation of symptoms due to its irritant properties. ... Persons with pre-existing skin disorders may be more susceptible to the effects of this agent. ... Those with pre-existing eye problems may be at increased risk from exposure.

Diisopropylamine was detected as a volatile constituent of raw beef(1).

Diisopropylamine's production and use as a chemical intermediate and catalyst(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 140(SRC) from a log Kow of 1.4(2) and a regression derived equation(3) indicates that diisopropylamine is expected to have high mobility in soil(SRC). A pKa value of 11.07(4) indicates that the protonated form of diisopropylamine will be the dominant species in moist soil surfaces and cations generally adsorb to organic carbon and clays more strongly than their neutral counterparts(SRC). Volatilization of diisopropylamine from moist soil surfaces is not expected to be an important fate process since the cation will not volatilize. The potential for volatilization of diisopropylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 79.4 mm Hg at 25 °C(5). Based on screening tests(6,7), biodegradation may be an important fate process in soil, providing sufficient acclimation has occured. However, high concns of diisopropylamine (> 50 ppm) appear to be toxic to microorganisms and, thus, may reduce biodegradation(6,7).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 140(SRC) from a log Kow of 1.4(2) and a regression derived equation(3) indicates that diisopropylamine is not expected to adsorb to suspended solids and sediment in water(SRC). A pKa value of 11.07(4) indicates that the protonated form of diisopropylamine will be the predominant species in water and cations generally adsorb more strongly than their neutral counterparts. Volatilization from water surfaces is not expected to be important fate process(SRC) since the protonated form is not expected to volatilize at environmental pH. According to a classification scheme(5), an estimated BCF of 2(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Based on screening tests(7,8), biodegradation may be an important fate process in aquatic systems providing sufficient acclimation has occurred.|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diisopropylamine, which has a vapor pressure of 79.4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diisopropylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4 hours(SRC), from its rate constant of 9.7X10-11 cu cm/molecule-sec at 25 °C(3). Diisopropylamine is not expected to directly photolyze due to the lack of absorption in the environmental UV spectrum(SRC).

The rate constant for the vapor-phase reaction of diisopropylamine with photochemically-produced hydroxyl radicals has been estimated as 9.7X10-11 cu cm/molecule-sec at 25 °C(SRC)(1). This corresponds to an atmospheric half-life of about 4 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Diisopropylamine will exist predominantly in the protonated form in the environment based on a pKa value of 11.07(2). Diisopropylamine is not expected to directly photolyze due to the lack of absorption in the environmental UV spectrum(SRC).

An estimated BCF of 2 was calculated for diisopropylamine(SRC), using a log Kow of 1.4(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of diisopropylamine was estimated as 140(SRC), using a log Kow of 1.4(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that diisopropylamine is expected to have high mobility in soil(SRC). The pKa of diisopropylamine is 11.07(4), indicating that the protonated form will be the predominant species in moist soils and cationic molecules generally adsorb to organic carbon and clays more strongly than their neutral counterparts(SRC).

With a pKa of 11.07(1), diisopropylamine will exist predominantly in its protonated form in the environment and the protonated form of diisopropylamine will not volatilize from water or moist soil surfaces at environmental pH(2). Diisopropylamine may volatilize from dry soil surfaces(SRC) based on its vapor pressure of 79.4 mm Hg at 25 °C(3).

Diisopropylamine was detected in raw beef at a concn of 0.05 ug/kg(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 4,354 workers (729 of these are female) are potentially exposed to diisopropylamine in the US(1). Occupational exposure to diisopropylamine may occur through inhalation and dermal contact with this compound at workplaces where diisopropylamine is produced or used(SRC).

Antihypertensive Agents; Indicators and Reagents|EXPTL USE: BLOOD PRESSURE IN RENAL HYPERTENSIVE DOGS WAS LOWERED AND NORMALIZED AFTER GASTRIC INFUSION OF 50-100 MG DIISOPROPYLAMINE SALICYLATE FOR 2 WK. /DIISOPRPPYLINE SALICYLATE/|EXPTL USE: DIISOPROPYLAMINE HYDROCHLORIDE DECR BLOOD PRESSURE OF PT WITH HYPERTENSION FOR 6 HR @ DOSES GREATER THAN OR EQUAL TO 12.5 MG IV. /DIISOPROPYLAMINE HYDROCHLORIDE/

Inhalation of vapors causes irritation, sometimes with nausea and vomiting; can also cause burns to the respiratory system. Ingestion causes irritation of mouth and stomach. Vapor irritates eyes; liquid causes severe burn, like caustic. Contact with skin causes irritation. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)|(See procedures)

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.

Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes. Refer immediately for medical attention.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/amines and related cmpds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconsious or has severe pulmonary edema. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's of hypovolemia are present. Watch for signs of fluid overload. Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/amines and related cmpds/

Symptoms: Nausea in low concentrations and pulmonary edema in high concentrations.|Inhalation of vapors causes irritation, sometimes with nausea and vomiting; can also cause burns to the respiratory system. ... /Liquid/ causes smarting of the skin and first-degree burns on short exposure; may cause second-degree burns on long exposure.|In humans, diisopropylamine is an eye irritant. When exposed to concentrations between 25 and 50 ppm, workers complained of disturbances of vision. There were also complaints of nausea and headache.|Edema of the epithelium of the cornea, generally without pain, has been produced by amine vapors, causing colored haloes to be seen around lights, usually in the evening, after industrial exposure to the vapors of various amines including ... diisopropylamine.|TEMPORARY IMPAIRMENT OF VISION HAS OCCURRED IN MEN AFTER EXPOSURE TO VAPOR CONCN...AS LOW AS 25 TO 50 PPM IN AIR DURING DISTILLATION OF DIISOPROPYLAMINES /PRESUMABLY DUE TO INJURY TO CORNEAL EPITHELIUM/...

diisopropylamine

Serious local effects by all routes of exposure.|inhalation, skin absorption, ingestion, skin and/or eye contact

irritation eyes, skin, respiratory system; nausea, vomiting; headache; visual disturbance

Cough. Sore throat. Burning sensation. Shortness of breath. Laboured breathing.

Redness. Pain. Serious skin burns.

Redness. Pain. Blurred vision. Severe burns.

Eyes, skin, respiratory system

GRADES OR PURITY: COMMERCIAL, 100%.|Grade: Technical.

Agriculture, forestry, fishing and hunting|2-Propanamine, N-(1-methylethyl)-: ACTIVE

ANALYTE: DIISOPROPYLAMINE. MATRIX: AIR. PROCEDURE: COLLECTION IN 0.1 N SULFURIC ACID IMPINGERS, GAS CHROMATOGRAPHY/FLAME IONIZATION DETECTION. RANGE: 8.5-37.4 MG/CU M.|GC OF SECONDARY AMINES IN FOODS WITH FLAME PHOTOMETRIC DETECTION AFTER DERIVATIZATION WITH BENZENESULFONYL CHLORIDE.|DETERMINATION OF DIISOPROPYLAMINE BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY, USING SODIUM NAPHTHALENE-2-SULFONATE AS COUNTER ION IN THE AQ STATIONARY PHASE.|The retention behavior for mixtures of n-alkanes and diisopropylaminoalkanes was examined on 4 fused silica capillary columns in a splitless injection mode.|For more Analytic Laboratory Methods (Complete) data for DIISOPROPYLAMINE (6 total), please visit the HSDB record page.

Fire Hazards -> Flammable - 3rd degree