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Flavonoids

Isorhamnetin 3-O-glucoside

(5041-82-7)
Isorhamnetin-3-O-glucoside, a natural compound widely contained in many vegetables and rice, could be metabolized in intestinal microbiota after digestion[1].

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Tiliroside

(20316-62-5)
Tiliroside, a glycosidic flavonoid, possesses anti-diabetic activities. Tiliroside is a noncompetitive inhibitor of α-amylase with a Ki value of 84.2  μM. Tiliroside inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract[1].

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(11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1Z)-1-propen-1-ylestra-4,9-dien-3-one

(124478-60-0)
Aglepristone is labeled (in the U.K. and elsewhere) for pregnancy termination in bitches up to 45 days after mating.
In dogs, aglepristone may prove useful in inducing parturition or treating pyometra complex (often in combination with a prostaglandin F analog such as cloprostenol).
In cats, it may be of benefit for pregnancy termination (one study documented 87% efficacy when administered at the recommended dog dose at day 25) or in treating mammary hyperplasias or pyometras.

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Kaempferide

(491-54-3)
Kaempferide is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga (aromatic ginger). The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide. P-glycoproteins.

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Bavachin

(19879-32-4)
Bavachin, a flavonoid first isolated from seeds of P. corylifolia, acts as a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC50s of 320 and 680 nM, respectively.

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Rhoifolin

(17306-46-6)
Rhoifolin is a flavone, a type of flavonoid, a new natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea. Rhoifolin has been shown to be an apigenin-7-rhamnoglucoside. Rhoifolin apparently is identical with the apigenin-7-rhamnoglucoside obtained by the bromination and dehydrobromination of Naringin (N378980).

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Prunetin

(552-59-0)
Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor[1][2].

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Isoxanthohumol

(70872-29-6)
(2S)-Isoxanthohumol is a microbial biotransformed metabolite of the hop prenylflavanone Isoxanthohumol[1].

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Jaceosidin

(18085-97-7)
Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression[1]. Jaceosidin exhibits anti-cancer[2], anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation[3].

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Kaempferol 3-O-rutinoside

(17650-84-9)
Nicotiflorin is a flavonoid glycoside extracted from a traditional Chinese medicine Flos Carthami. Nicotiflorin shows potent antiglycation activity and neuroprotection effects.

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Flavonoids, also known as bioflavonoids (bioflavonoids), are a type of compound that exists in nature and has a 2-phenyl flavonone structure. Widely distributed in the plant kingdom, it is a large class of important natural compounds. Flavonoids mostly have colors, and their different colors add more colors to the family of natural pigments.

Frequently Asked Questions

What are flavonoids and why are they important?

Flavonoids are a diverse group of phytonutrients found in almost all fruits and vegetables. They are known for their antioxidant, anti-inflammatory, and immune-supporting properties. Common subclasses include flavones, flavonols, flavanones, isoflavones, and anthocyanidins. Due to their health-promoting effects, flavonoids are widely used in dietary supplements, functional foods, and natural therapeutics.

What are the common natural sources of flavonoids?

Flavonoids occur naturally in a wide variety of plant-based foods and beverages. Rich sources include citrus fruits (flavanones), berries (anthocyanidins), onions and apples (flavonols), soybeans (isoflavones), and tea—especially green and black tea (catechins and theaflavins). Including a colorful diet with diverse fruits, vegetables, legumes, and herbs helps ensure adequate flavonoid intake.

What should buyers consider when sourcing high-quality flavonoid extracts?

When sourcing flavonoid extracts, buyers should evaluate:1. Purity and concentration levels (e.g., HPLC-certified assays).2. Botanical origin and extraction method (e.g., solvent-free or ethanol-based).3. Compliance with regulatory standards like ISO, GMP, or FDA GRAS status.4. Supplier transparency regarding heavy metals, pesticides, and microbial testing.5. Batch-to-batch consistency and documentation (Certificates of Analysis).These factors ensure safety, efficacy, and suitability for end-use applications.

Are there different types of flavonoid compounds used commercially?

Yes, several flavonoid compounds are commonly used in commercial products. Key examples include quercetin (a flavonol with strong antioxidant activity), hesperidin (a citrus flavanone supporting vascular health), epigallocatechin gallate (EGCG from green tea, known for metabolism support), genistein (a soy isoflavone used in hormonal health formulations), and rutin (used for capillary strength and anti-edema effects). Each type offers distinct biological activities and application benefits.

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