Ethambutol Hydrochloride Capsules

This product is a synthetic antibacterial anti-tuberculosis drug. It has strong activity against bacteria in the growth and reproduction stage, but almost no effect on bacteria in the dormant stage. It has high antibacterial activity against various types of mycobacteria. There is no cross-resistance between tuberculosis bacteria and this product and other drugs. The mechanism of action of this product has not been fully elucidated. It may be related to inhibiting the metabolism of sensitive bacteria, inhibiting the synthesis of RNA, and interfering with the protein metabolism of tuberculosis bacteria, thereby leading to bacterial death.

The main component of this product is ethambutol hydrochloride, and its chemical name is [2R, 2[S-(R*, R*)]-R]-()2,2'-(1,2-ethylenediimino)-bis-1-butanol dihydrochloride. Its structural formula is: Molecular formula: C10H24N2O22HCl Molecular weight: 277.23

This product is in the form of capsules.

This product is suitable for the treatment of pulmonary tuberculosis and extrapulmonary tuberculosis caused by Mycobacterium tuberculosis in combination with other anti-tuberculosis drugs, and can also be used to treat atypical Mycobacterium tuberculosis infection.

It needs to be used in combination with other anti-tuberculosis drugs. 1. Initial treatment: Oral, 15 mg/kg per body weight, once a day; or 25-30 mg/kg per time, up to 2.5 g, 3 times a week; or 50 mg/kg per body weight, up to 2.5 g twice a week. 2. Re-treatment: Oral, 25 mg/kg per body weight, once a day, for 60 consecutive days, followed by 15 mg/kg per body weight, once a day. 3. Atypical tuberculosis infection: 15-25 mg/kg per body weight, once a day.

1. Common optic nerve damage, such as retrobulbar optic neuritis and damage to the central fibers of the optic nerve. This may be related to the decrease in the content of these metal elements caused by the chelation of this product with copper, zinc and other metal elements. The incidence of retrobulbar optic neuritis is about 0.8%, which is related to the dosage and course of treatment. It is easy to occur when taking the drug for a long time and the daily dose is greater than 25mg/kg. The incidence rate is 1% at a daily dose of 15mg/kg, 6% at 25mg/kg, and 15% at 35mg/kg. Manifestations include blurred vision, eye pain, red-green color blindness or decreased vision, and narrowed visual field. If the above reactions are discovered early and the drug is stopped in time, they will disappear on their own within weeks or months, and permanent loss of visual function rarely occurs. 2. Rare chills, joint swelling and pain (especially the big toe, condyle, and knee joints), and fever and tension on the surface of the affected joint skin (acute gout, hyperuricemia). 3. Gastrointestinal discomfort, nausea, vomiting, diarrhea, liver damage, peripheral neuritis (often manifested as numbness, tingling, burning pain, or weakness in the hands and feet) and allergic reactions (often manifested as rash, itching, headache, fever, joint pain), etc. are occasionally seen.

People who are allergic to this product, patients with known optic neuritis, ethanol poisoning, and those under 13 years old should use it with caution.

1. Aluminum salts, including DDI buffer, can reduce the absorption of this product. 2. Combination of this product with verapamil can reduce the absorption of the latter. 3. Combination with neurotoxic drugs can increase the neurotoxicity of this product, such as optic neuritis or peripheral neuritis. 4. Combination with ethionamide can increase adverse reactions such as icteric hepatitis and optic neuritis.

Keep away from light, sealed and stored in a dry place.

0.25g

Hebei Yineng Pu Pharmaceutical Co., Ltd.

• Founded in:

  2003-09-04

• Address:

  No. 1 Yinengpu Avenue, Zhuolu County

• Tax NO.:

  91130731754015073N

• Registered Funds:

  20 million yuan

• Email:

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