Alprostadil Injection

This product is an intravenous alprostadil preparation with lipid microspheres as drug carriers. Due to the encapsulation of lipid microspheres, alprostadil is not easy to be inactivated. In addition, this product has the targeting characteristics of being easily distributed to damaged blood vessels, thereby exerting the effects of this product in dilating blood vessels and inhibiting platelet aggregation.

The main ingredient is alprostadil. Its chemical name is (1R, 2R, 3R)-3-hydroxy-2[(E)-(3S)-3-hydroxy-1-octenyl]-5-oxocyclopentaneheptanoic acid. Molecular formula: C20H34O5. Molecular weight: 354.49.

This product is a white milky liquid.

Treat limb ulcers caused by chronic arterial occlusive disease (thromboangiitis obliterans, arteriosclerosis obliterans) and limb rest pain caused by microvascular circulatory disorders, and improve cardiovascular and cerebrovascular microcirculatory disorders. Antithrombotic therapy after organ transplantation to inhibit thrombosis in transplanted blood vessels. Patent ductus arteriosus in children with congenital heart disease is used to relieve hypoxemia and maintain ductal blood flow to wait for the opportunity for surgical treatment.

For adults, once a day, 1-2 ml (alprostadil 5-10 μg) + 10 ml normal saline (or 5% glucose) intravenously or directly into a small pot.

1 Shock: Shock may occur occasionally. Please pay attention to observation. If any abnormality is found, stop the drug immediately and take appropriate measures. 2 Injection site: Sometimes there may be pain and redness in the blood vessels, and occasionally hardening and itching. 3 Circulatory system: Sometimes there may be worsening of heart failure, pulmonary edema, chest tightness, and decreased blood pressure. If these symptoms occur, stop the drug immediately. In addition, redness and vasculitis may occur occasionally, and facial flushing and palpitations may occur occasionally. 4 Digestive system: Sometimes there may be diarrhea, bloating, and discomfort, and occasionally abdominal pain, loss of appetite, vomiting, and constipation. 5 Liver: Occasionally there may be abnormal liver function such as increased GOT and GPT. 6 Mental and nervous system: Sometimes there may be dizziness, headache, fever, fatigue, and occasionally numbness. 7 Skin: Sometimes there may be rashes or itching, and occasionally urticaria.

1. Patients with severe heart failure (heart failure). 2. Women who are pregnant or may become pregnant. 3. Patients with a history of allergy to this preparation.

Precautions for children: For children with congenital heart disease, the recommended infusion rate is 5ng/kg/min. Precautions for pregnancy and lactation: Women who are pregnant or may become pregnant. Precautions for the elderly: No special instructions, please follow the doctor's advice.

Avoid mixing with plasma expanders (dextran, gelatin preparations, etc.).

Keep in a light-proof and airtight container.

2ml:10μg

12 months.

Beijing Tide Pharmaceutical Co., Ltd.

• Founded in:

  1995-05-29

• Address:

  No. 8 Rongjing East Street, Beijing Economic and Technological Development Zone, Beijing

• Tax NO.:

  911103026000314683

• Registered Funds:

  500 million yuan

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