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Compound diisopropylamine dichloroacetate injection

Function and Efficacy

1. Effect on fatty liver: Consume liver fat: This product is decomposed into diisopropylamine and dichloroacetic acid in the body. The former generates methionine under the activation of ATP, and the latter is metabolized to glycine. Under the action of glycine lyase, N5N10-CH2-FH4 (methyltetrahydrofolate) is generated, and energy is provided at the same time. Both can provide methyl groups to promote choline synthesis. Choline reacts with liver fat to generate lecithin and promote the decomposition of liver fat. Transport liver fat: Lecithin, liver fat, cholesterol and apolipoprotein are combined into lipoprotein. Lipoprotein is easily soluble in plasma, thereby transporting fat from the liver to the outside of the liver and reducing the accumulation of fat in the liver. This product can reduce the concentration of glycerol and free fatty acids in arterial blood and reduce the liver's absorption of glycerol. At the same time, it stimulates triglycerides to enter the blood in the form of very low-density lipoprotein (VLDL), thereby effectively inhibiting the synthesis of triglycerides in the liver. 2. Effect on lipid metabolism: This product inhibits fat mobilization by inhibiting the activity of hormone-sensitive lipase; inhibits cholesterol synthesis by inhibiting the activity of the rate-limiting enzyme for cholesterol synthesis (HMGCoA reductase); inhibits fatty acid synthesis by inhibiting the activity of citrate synthase and acetyl-CoA carboxylase in the citrate-pyruvate cycle. 3. Liver protection: Improves the energy metabolism of liver cells. By promoting the sequential methylation of membrane phospholipids, the fluidity of liver cell membranes is enhanced, and the activity of Na-K-ATPase, which is the main driving force for bile secretion and flow, is increased; promotes the functional repair of damaged liver cells, improves the respiratory function and oxygen utilization of tissue cells; increases the metabolic activity of fatty acids, accelerates the oxidation of fatty acids, and creates conditions for the recovery of liver function.

Ingredients

This product is a compound preparation, and its composition is: each 1ml contains 20mg of diisopropylamine dichloroacetate and 19mg of sodium gluconate.

Name Description Content CAS NO. Manufacturer
Diisopropylammonium dichloroacetateIngredients

Effect on fatty liver: decomposed into diisopropylamine and dichloroacetic acid in the body, promoting choline synthesis and consuming liver fat; Effect on lipid metabolism: inhibit fat mobilization, cholesterol synthesis and fatty acid synthesis; Liver protection effect: improve liver cell energy metabolism, enhance liver cell membrane fluidity, increase Na-K-ATPase activity, promote damaged liver cell function repair, and accelerate fatty acid oxidation.

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660-27-5 14
Sodium gluconateIngredients

Participates in energy metabolism and supports liver function recovery.

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527-07-1 13

Indication

Liver-protecting medicine. Used for fatty liver, intrahepatic cholestasis, and general liver dysfunction. Used for acute and chronic hepatitis, hepatomegaly, and early cirrhosis.

Usage and Dosage

Intramuscular injection: 40 mg (1 vial), 1-2 times a day. Intravenous injection: 40 mg (1 vial), 1-2 times a day. Intravenous drip: 40-80 mg (1-2 vials), 1-2 times a day, diluted to an appropriate amount (50-100 ml) with 5% or 10% glucose solution or 0.9% sodium chloride solution. The course of treatment is as prescribed by the doctor.

Adverse Reactions

Occasionally, you may experience dizziness, thirst, loss of appetite, etc., but these symptoms may disappear on their own.

Precautions

People who are allergic to this product are prohibited from using it. If an allergic reaction occurs, the symptoms will disappear after stopping the drug.

Drug Interactions

Not yet clear

Storage

Keep away from light and store in a sealed container.

Packaging Specification

2ml: diisopropylamine dichloroacetate 40mg, sodium gluconate 38mg

Manufacturer

Dalian Huali Jingang Pharmaceutical Co., Ltd.

  • Founded in:

    1992-12-03
  • Address:

    No. 8 Chengen Street, Jinzhou District, Dalian City, Liaoning Province
  • Tax NO.:

    912102136048258717
  • Registered Funds:

    8.88 million yuan
  • Website:

  • Email:

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