Isotretinoin capsules

1. Pharmacology: The mechanism of action of this drug is not yet fully understood. When used to treat acne, it can shrink sebaceous gland tissue, inhibit sebaceous gland activity, reduce sebum secretion, reduce epithelial cell keratinization and keratin plugging at the mouth of hair follicle sebaceous glands, and inhibit the growth and reproduction of Propionibacterium acnes. Recent studies have also shown that this drug can regulate inflammatory immune mediators related to the pathogenesis of acne and selectively bind to retinoic acid nuclear receptors to exert a therapeutic effect. 2. Toxicology: Tests have shown that it has severe teratogenic effects.

The main ingredient of this product is: isotretinoin, also known as 13-cis retinoic acid.

This product is dark brown capsules, and the contents are orange-yellow oily suspension.

It is suitable for severe acne, especially nodular cystic acne, and can also be used for diseases such as pityriasis rubra pilaris.

This product should be used under the guidance of a doctor. The oral dose for the treatment of acne should vary from person to person, ranging from 0.1 to 1 (mg/kg)/day. The generally recommended starting dose is 0.5 (mg/kg)/day, taken orally twice. This drug is fat-soluble, and taking it with meals can promote absorption. After 2 to 4 weeks of treatment, the dose can be adjusted as appropriate based on clinical effects and adverse reactions. A course of treatment is 6 to 8 weeks, and the drug can be discontinued for 8 weeks between courses. Symptoms can be continuously improved in the short term after discontinuation of the drug.

1. The side effects of this drug are similar to the clinical manifestations of vitamin A overdose. Common side effects include dry lips and skin, cheilitis, desquamation, itching, pain, rash, increased skin fragility, peeling of the palms and soles, ecchymosis, and secondary infection may also occur. 2. Conjunctivitis, and in severe cases, corneal opacities, visual impairment, papilledema, headache, dizziness, mental symptoms, depression, and benign intracranial hypertension. 3. Loose hair and soft nails. 4. Osteoporosis, muscle weakness, pain, gastrointestinal symptoms, epistaxis, etc. 5. Taking the drug during pregnancy may lead to spontaneous abortion and fetal malformations. 6. Laboratory tests may cause rapid erythrocyte sedimentation rate, elevated liver enzymes, elevated blood lipids, elevated blood sugar, and decreased platelets. Most of the above side effects are reversible and can be gradually recovered after stopping the drug. Mild side effects

It is contraindicated for use by pregnant women, lactating women, patients with liver and kidney dysfunction, vitamin A excess and hyperlipidemia.

Precautions for children: The safety for children is not yet known. Overdose may cause changes in bone structure, including premature fusion of epiphyseal discs in children. Precautions for pregnancy and lactation: Women of childbearing age and their spouses should strictly practice contraception during medication, before medication, and within 3 months after stopping medication. A pregnancy test should be performed 2 weeks before treatment and once a month thereafter to ensure that there is no pregnancy. Precautions for the elderly: It is contraindicated for patients with impaired liver and kidney function.

1. The combination of isotretinoin and tetracycline antibiotics can lead to pseudo-"brain tumors" and cause benign intracranial hypertension, with clinical manifestations of hypertension accompanied by headaches, dizziness and visual impairment. 2. The simultaneous use of isotretinoin and vitamin A can produce symptoms similar to those of vitamin A overdose. 3. The simultaneous use of isotretinoin and carbamazepine can lead to a decrease in the blood concentration of carbamazepine. The simultaneous use of isotretinoin and warfarin can enhance the therapeutic effect of warfarin. The simultaneous use of isotretinoin and methotrexate (MTX) can increase liver damage due to the increase in the blood concentration of MTX.

Seal and store in a cool place.

10 mg

24 months

Shanghai Donghai Pharmaceutical Co., Ltd.

• Founded in:

  1995-11-06

• Address:

  Area A, 2nd Floor, Building 6, No. 88 Chenxiang Road, Jiading District, Shanghai

• Tax NO.:

  91310000132244461T

• Registered Funds:

  68.75 million yuan

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