Azathioprine 99.0% White crystalline powder Yuanjinchem
446-86-6
Pharmaceutical Grade
99%
Shanghai
Yuanjinchem
25kg/drum
2022-06-25
Pharmaceutical intermedaite,Agricultural chemical intermediate
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Product Description
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Seller Information
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DescriptionBasic Info
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Product Name:
Azathioprine
Other Name:9H-Purine,6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-;Purine,6-[(1-methyl-4-nitroimidazol-5-yl)thio]-;1H-Purine,6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-;6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine;NSC 39084;Azathioprine;Azothioprine;Imuran;6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine;6-(1-Methyl-4-nitromidazol-5-ylthio)purine;Muran;BW 57-322;Imurel;Imurek;Azathioprin;Azanin;Azoran;Azamune;Azathropine;Azafor;Azasan;6165-04-4;11120-16-4;33609-91-5
CAS No.:446-86-6
Molecular Formula:C9H7N7O2S
InChIKeys:InChIKey=LMEKQMALGUDUQG-UHFFFAOYSA-N
Molecular Weight:277.27
Exact Mass:277.26
EC Number:207-175-4
UNII:MRK240IY2L
NSC Number:755900|39084
DSSTox ID:DTXSID4020119
NCI Thesaurus Code:C290
Color/Form:Pale yellow crystals from 50% aq acetone
ATC Code:L04AX01|L - Antineoplastic and immunomodulating agents
HScode:2933990090
Categories:
Characteristics-
PSA:
143
XLogP3:0.1
Appearance:Azathioprine appears as pale yellow crystals or yellowish powder. Decomposes at 243-244°C. Used for the treatment of rheumatoid arthritis. A known carcinogen.
Density:1.9±0.1 g/cm3
Melting Point:243.5 °C
Boiling Point:555.8°C at 760 mmHg
Flash Point:368.5±31.5 °C
Refractive Index:1.924
Water Solubility:H2O: <0.1 g/100 mL at 23 ºC;soluble in Dichloromethane and dimethyl sulfoxide.
Storage Conditions:Freezer
Vapor Pressure:7.98E-12mmHg at 25°C
Toxicity:Oral-rat LD50: 535 mg/kg; Oral-Mouse LD50: 1389 mg/kg
Flammability characteristics:It can burn and produce toxic nitrogen and sulfur oxide fumes; side effects of patients after use: changes in liver function, excessive gastrointestinal movement, nausea, vomiting, diarrhea, increased body temperature, low blood pressure, low urine output, no urine
PKA:7.87(at 25 °C)
Dissociation Constants:7.87 (at 25 °C)|pKa = 8.2
Collision Cross Section:155.1 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Soly in water: 10 mg/ml /Sodium salt/
Air and Water Reactions:Sensitive to oxidation in the air. Insoluble in water.
Reactive Group:Amines, Phosphines, and Pyridines
Reactivity Profile:AZATHIOPRINE may react exothermically with acids. Incompatible with isocyanates, peroxides, phenols, epoxides, anhydrides, and acid halides. Hydrolyzed by strongly basic solutions (NTP, 1992). May react with strong reducing agents to generate flammable gaseous hydrogen or hydrogen sulfide.
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
Germ cell mutagenicity, Category 1A
Carcinogenicity, Category 1A
Reproductive toxicity, Category 1A
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H340 May cause genetic defects
H350 May cause cancer
H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P203 Obtain, read and follow all safety instructions before use.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
P318 IF exposed or concerned, get medical advice.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Storage of the constituted soln in the original vial and in plastic syringes (Jelco) at 20-25 deg C under fluorescent light resulted in no decomp or precipitation in 16 days. At 4 deg C in the dark, a visible precipitate formed after four days. Azathioprine sodium
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Seller Information
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Business Type:
Manufactory
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Main Products:
Pharmaceutical intermedaite,Agricultural chemical intermediate
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Location:
Jingxin building, No. 111 Lijiang Road, Xinchang County, Zhejiang Province
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A
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Average lead Time:
300
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
51-100
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Year of Establishment:
2014
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
