Andrographolide
2 Inquiries
5508-58-7
98%
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25kg/drum, double-layer plastic bags
2024-10-29
Drospirenone,Tretinoin,Tranexamic acid,Desogestrel,Diosmin,Isotretinoin
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Product Description
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Seller Information
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Inquiry History
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DescriptionKeywords
Andrographolide
Andrographolide high purity
5508-58-7 98%
Quick Details
ProName:Andrographolide
CasNo:5508-58-7
Molecular Formula:C20H30O5
Appearance:brown to white powder
Application:antiviral, anti-inflammatory, and anticancer
DeliveryTime:prompt
PackAge:25kg/drum, double-layer plastic bags
Port:Shanghai
ProductionCapacity:10 Metric Ton/Month
Purity:98%
Storage:cool and dry place avoiding sunlight
Transportation:by sea or by air
Details
Andrographolide is the bitter principle, a colorless and neutral crystalline substance. It is the major labdane diterpenoid isolated from Andrographis paniculate. It exhibits antiviral, anti-inflammatory, and anticancer activities. The underlying mechanism is the inhibition of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling (specifically p38 MAPK/ERK1/2) pathway and downstream transcription factors such as nuclear factor kappa B (NF-κB) and nuclear factor of activated T cells (NFAT). Andrographolide is also confirmed with chemopreventive effects against and the inhibitory effects on cancer cell growth in breast, colon, epidermoid, gastric, liver, leukemia, myeloma, peripheral blood lymphocytes, and prostate cancers. Andrographolide has been used for liver complaints and fever, and as an anti-inflammatory and immunostimulant. Andrographolide exerts anti-growth and pro-apoptotic effects on human rheumatoid arthritis fibroblast- like synoviocytes, the main cellular constituent of pannus, that combined with a massive infiltration of lymphocytes and macrophages, invades and destroys the local articular structure. Thereby, andrographolide is proposed to be used in Rheumatoid Arthritis and other autoimmune diseases.
Basic Info-
Product Name:
Andrographolide
Other Name:2(3H)-Furanone,3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-,(3E,4S)-;5β,9βH,10α-Labda-8(20),12-dien-16-oic acid,3α,14,15,18-tetrahydroxy-,γ-lactone;2(3H)-Furanone,3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-,[1R-[1α[E(S*)],4aβ,5α,6α,8aα]]-;Andrographis;(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone;Andrographolide;Andrographolid;3-dehydroandrographolide or 19-dehydroandrographolide? p. 1388;Andrographiside aglycon;101060-34-8;5953-53-7
CAS No.:5508-58-7
Molecular Formula:C20H30O5
InChIKeys:InChIKey=BOJKULTULYSRAS-OTESTREVSA-N
Molecular Weight:350.44900
Exact Mass:350.45
EC Number:226-852-5
HScode:29322980
Categories:
Characteristics-
PSA:
86.99000
XLogP3:2.2
Appearance:powder
Density:1.2317 g/cm3 @ Temp: 21 °C
Melting Point:218 °C (decomp)
Boiling Point:557.3ºC at 760 mmHg
Flash Point:195.5±23.6 °C
Refractive Index:1.567
Storage Conditions:Keep tightly closed. Store in a cool dry place.
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Drospirenone,Tretinoin,Tranexamic acid,Desogestrel,Diosmin,Isotretinoin
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Location:
1115JINGUI MANSION, GUDUN RD, HANGZHOU, CHINA
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
15
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
51-100
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Year of Establishment:
2005
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
Thailand
andrographolide
1 KG Jun 26, 2024 
India
andrographolidae
1 KG Jun 25, 2026 Post an enquiry for this product
