Dihexa, dihexa, PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide 99% white powder 1401708-83-5 Senwayer

Dihexa, also known by its developmental code name PNB-0408, is a nootropic drug derived from angiotensin IV. Angiotensin IV is a peptide hormone that affects the central nervous system and assists in the regulation of insulin and memory acquisition and recall. As a derivative of this hormone, Dihexa has been found to potentially assist in the improvement of the cognitive functions that decline as a result of Alzheimer’s disease, or other similar dementias, by augmenting synaptic connectivity. It was found to be more effective than that of brain-derived neurotrophic factor, or BDNF, and has the ability to penetrate the blood-brain barrier.

Dihexa has also been found to activate the formation of dendritic spines (responsible for transmitting electric signals to neuron cells).

For these reasons, some scientists speculate that Dihexa may be useful for treating dementia.

Dihexa requires more testing and clinical trials to prove both its safety and the benefits that it can provide. As only animal testing has currently been done on the nootropic, the potential benefits of the drug are not guaranteed. The possible benefits of the nootropic drug include:

• An improvement in critical thinking- Restoration of the synapses between neurons in the nervous system
• Improved production of dopamine and noradrenaline
• Increased mental stamina
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• Enhanced articulation
• Improved circulation
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• Accelerated wound healing
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• An increase in muscle growth
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• Reduction of cognitive decline in patients with Alzheimer’s disease or other degenerative cognitive diseases
• Enhanced creative thinking
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• Improvement of problem-solving abilities
• Improved cardiovascular health
• Increased motivation

Dihexa has only been lab and animal tested, so the inherent risk factors of the drug are not widely known. Personal accounts of individuals taking the drug give some insight into the possible risks, but the overall safety of long term use is still unclear. The use of the drug short term does pose the possibility of side effects. Potential side effects include a reduced attention span, irritability, mood swings, change of taste, increased anxiety, nausea, and insomnia.

Long term use of the drug poses an increased risk for certain cancers due to its mechanism of action. The drug should also not be taken with any other nootropic or psychoactive substances. Women who are pregnant or breastfeeding are recommended to avoid the drug as there is not enough conclusive evidence of its safety.

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