Ramelteon(TAK-375)
196597-26-9
99%
2026-07-20
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Ramelteon(TAK-375) Cat No CEI-0213 Description Ramelteon(TAK-375) Alias Rozerem, TAK-375 CAS No 196597-26-9 Molecular Weight 259.34 Purity >99% Storage 2 years at -20 centigrade Synonyms Rozerem, TAK-375 Targets MT1 receptor, MT2 receptor, MT receptor (chicken) Molecular Formula C16H21NO2 Solubility No In vitro Ramelteon (TAK-375) can inhibit MT1 receptor and MT2 receptor with Ki of 14 pM and 112 pM. Ramelteon has high affinity with recombinant human MT1 and MT2 receptors with pKi of 10.05 and 9.70. Ramelteon (1 nM) increases ERK1/2 phosphorylation not only in MT1/MT2 cerebellar granule cells but also in cerebellar granule cells expressing only one of the two melatonin receptors. category Standard(c2411) cas_num 196597-26-9 Basic Info-
Product Name:
Ramelteon
Other Name:Propanamide,N-[2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]-;Propanamide,N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]-,(S)-;N-[2-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide;TAK 375;Ramelteon;(S)-N-[2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide;Rozerem;(S)-N-[2-(1,6,7,8-Tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionamide;Rozerm
CAS No.:196597-26-9
Molecular Formula:C16H21NO2
InChIKeys:InChIKey=YLXDSYKOBKBWJQ-LBPRGKRZSA-N
Molecular Weight:259.349
Exact Mass:259.34
EC Number:-0
UNII:901AS54I69
DSSTox ID:DTXSID6045951
NCI Thesaurus Code:C66504
Color/Form:Crystals from ethyl acetate
ATC Code:N - Nervous system
Categories:
Characteristics-
PSA:
38.3
XLogP3:2.7
Appearance:Solid
Density:1.119±0.06 g/cm3(Predicted)
Melting Point:113-115 °C @ Solvent: Ethyl acetate
Boiling Point:455.3±24.0 °C(Predicted)
Flash Point:2℃
Refractive Index:1.556
Water Solubility:1.64e-02 g/L
Vapor Pressure:7.4X10-8 mm Hg at 25 deg C (est)
Specific rotation:Specific optical rotation: -57.8 deg at 20 °C/D (concentration = 1.004 g/100 mL in chloroform)
Henrys Law Constant:Henry's Law constant = 8.62X10-11 atm-cu m/mol at 25 °C (est)
Experimental Properties:Hydroxyl radical reaction rate constant = 9.87X10-11 cu cm/molec-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product