Genistein
9 Inquiries
446-72-0
2026-06-28
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName Genistein Cat No CEI-0900 Description Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. CAS No 446-72-0 Molecular Weight 270.24 Storage 2 years -20 centigrade Powder; 2 weeks 4 centigrade in DMSO; 6 months -80 centigrade in DMSO. Targets PTK Molecular Formula C15H10O5 Chemical Name 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one Solubility DMSO 54 mg/mL; Water <1 mg/mL; Ethanol 2 mg/mL In vitro Genistein is an ATP competitive inhibitor. Genistein inhibits tyrosine phosphorylation in isolated enzyme and receptor preparations and in whole cells including platelets, lymphocytes and a variety of cultured cells. It also inhibits EGF-stimulated phosphorylation in cultured cells as well as inhibition of Topo II (topoisomerase II). Genistein inhibits EGF-stimulated tyrosine phosphorylation in cultured A431 epidermoid carcinoma cells. Inhibition is competitive with ATP and noncompetitive with substrate. Genistein blocks the mitogenic effect mediated by EGF, insulin and thrombin on NIH-3T3 cells.Genistein also acts as an agonist at the GPR30 receptor and binds to PPARγ and estrogen receptors. Genistein also binds to PPARγ, acting as an agonist at this receptor with Ki of 5.7 μM. In vivo Genistein has chemopreventive effects on breast, prostate, and other endocrine-dependent tumors in adult animals. Genistein in the diet reduced the incidence of poorly differentiated prostatic adenocarcinomas in a dose-dependent manner and down-regulated androgen receptor, estrogen receptor-alpha, progesterone receptor, epidermal growth factor receptor, insulin-like growth factor-I, and extracellular signal-regulated kinase-1 but not estrogen receptor-beta and transforming growth factor-alpha mRNA expressions. Dietary genistein protects against mammary and prostate cancers by regulating specific sex steroid receptors and growth factor signaling pathways.Genistein combined with prostate tumor irradiation causes greater inhibition of primary tumor growth and increases control of spontaneous metastasis to para-aortic lymph nodes, increasing mouse survival. Paradoxically, treatment with genistein alone increases metastasis to lymph nodes. category Biosynthetic Natural Products(c1523) cas_num 446-72-0 Basic Info-
Product Name:
Genistein
Other Name:4H-1-Benzopyran-4-one,5,7-dihydroxy-3-(4-hydroxyphenyl)-;Genistein;Isoflavone,4′,5,7-trihydroxy-;5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;C.I. 75610;Genisteol;Prunetol;Sophoricol;4′,5,7-Trihydroxyisoflavone;Genisterin;5,7,4′-Trihydroxyisoflavone;NPI 031L;Baichanin A;SIPI 807-1;NSC 36586;Bonistein;FW 635I-2;GeniVida;Climagen F;5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one;Genistin aglycone;CSU-1999;CSU 1999;BIO 300;944110-99-0
CAS No.:446-72-0
Molecular Formula:C15H10O5
InChIKeys:InChIKey=TZBJGXHYKVUXJN-UHFFFAOYSA-N
Molecular Weight:270.24
Exact Mass:270.24
BRN:263823
EC Number:207-174-9
HScode:2932999099
Categories:
Characteristics-
PSA:
87
XLogP3:2.84 (est)
Appearance:off-white powder
Density:1.5±0.1 g/cm3
Melting Point:301.5 °C (decomp)
Boiling Point:555.5±50.0 °C at 760 mmHg
Flash Point:217.1±23.6 °C
Refractive Index:1.732
Water Solubility:H2O: insoluble ;DMSO: soluble
Storage Conditions:−20°C
Vapor Pressure:5.2X10-12 mm Hg at 25 deg C (est)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
P391 Collect spillage.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History9 Inquiries
Country Product Purchase Quantity Date Posted 
Poland
Genistein 98%
1 KG Jan 6, 2025
Poland
genisteina
1 KG Jan 6, 2025
Poland
genistein
1 KG Jan 6, 2025 
India
Genistein
2 G Jan 21, 2024
India
Genistein
500 G Mar 25, 2026 
China
Genistein
25 KG Mar 13, 2026 
South Korea
Genistein
10 KG Nov 28, 2025
India
Genistein
20 G Aug 29, 2025 
Canada
Sophora japonica extract genistein 98%
1 KG Oct 7, 2023 Post an enquiry for this product