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59-05-2 | ChemExpress

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CAS No.:

59-05-2

Port:

shanghai

Packaging:

10 kg

Price valid (until):

2024-04-01

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ChemExpress

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

CRO

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Product Description
Seller Information
Inquiry History

Description

Methotrexate
Payload
We can provide high-quality Methotrexate and its derived impurities.

Brand：ChemExpress
CAS：59-05-2
Catalog_No：HY-14519

Contact:
TEL：+1-970-439-2030 (USA)、+86 (21) 5895-0125 (Global)
Email：info@chemexpress.com

Brand Introduction:
ChemExpress focuses on providing small molecule and new modalities CDMO services for both pharmaceutical and biotech clients. Our comprehensive CRO & CDMO platform is engaged in the research and development, manufacturing and supply of regulatory starting materials, novel building blocks, intermediates, reference compounds, APIs and drug products. We are a one-stop service platform to support our client’s projects from early drug discovery, process development to commercialization.

ChemExpress Services:

Drug Discovery: synthetic chemistry; medicine chemistry; FTE/FFS services.

Process Development: APIs and intermediates development; formulation development.

New Modalities Development: ADC; peptide; oligonucleotide and so on.

Manufactory: support production from milligrams to kilograms, both with GMP and non-GMP capabilities.

Analytical Development & Quality Control: R&D testing; stability study; genotoxic impurity research and so on.

Regulatory CMC Support

Eany development services in Synthetic Chemistny:Providing serices related to high qualty compound synthesis,chemical custom synthesis and analytical chemistry.

Pharmaceutical Chemistry eaniy development services: including high-throughput screening, drug synthesis, seding compounds, lead compounds, and IND fling support.

Process development: Covers AP! & intermediates process development, validation, transfer, and formulation development.

Commerial producion:it hasa research and development base forthe producion otapis intermediates and prenarations and provdes commeria prouction semices.

CMC services: Provide one-stop CMC services, from lND to NDA stage of pharmaceutical research and development and dedlaration services, accelerate IND declaration.

ADC drug and highly active drug development and production: Provides a one-stop CRO & CDMO service for the small molecule aspect of ADC drugs, as well as customized ADC conjugation services.

Oligonucleotide drug process development and production: Provide oligonucleotide customized products and services to meet different needs.

Analytical testing services and quality control: Provide integrated analytical testing services and drug quality research support

ChemExpress committed to being a steadfast companion for our clients, gaining profound insight into their needs. Our focus is on accelerating the empowerment of global partners across the full spectrum, from preclinical stages to commercial production. This commitment aims for more streamlined drug development, swifter market entry, and an earlier positive impact on human health.

Product details：https://www.chemexpress.com/product/HY-14519

Basic Info

Product Name:

Methotrexate

Other Name:

METHOTREXATEFORINJECTION;sodium 4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]am ino]-5-hydroxy-5-oxo-pentanoate;METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID);4-Amino-N10-methylfolic acid;Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI);L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI);L-Methotrexate;Methotrexat-Ebewe

CAS No.:

59-05-2

Molecular Formula:

C20H22N8O5

InChIKeys:

FBOZXECLQNJBKD-ZDUSSCGKSA-N

Molecular Weight:

454.44

Exact Mass:

454.44

BRN:

70669

EC Number:

200-413-8

UNII:

YL5FZ2Y5U1

NSC Number:

740

UN Number:

3249

TSCA:

TSCA listed

DSSTox ID:

DTXSID4020822

NCI Thesaurus Code:

C642

Color/Form:

Light yellow to yellow

ATC Code:

L04AX03|L01BA01|L - Antineoplastic and immunomodulating agents

HScode:

29335995

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

211

XLogP3:

-1.8

Appearance:

powder

Density:

1.4080 (rough estimate)

Melting Point:

195°C

Boiling Point:

561.26°C (rough estimate)

Flash Point:

11℃

Refractive Index:

1.6910 (estimate)

Water Solubility:

Insoluble. <0.1 g/100 mL at 19 ºC

Storage Conditions:

−20°C

Vapor Pressure:

2.1X10-19 mm Hg at 25 deg C /Estimated/

Toxicity:

LD50 oral in rat: 135mg/kg

Specific rotation:

Specific optical rotation: 20.4 + or - 0.6 deg at 21 °C/589 D (concentration by 0.1 N sodium hydroxide) maximum absorption: 243nm, A1= 388;307 nm, A1 = 475 (in 0.1 n hydrogen chloride). 258 nm, A1= 544; 303 nm, A1= 546; 372 nm, A1= 177 (in 0.1 N sodium hydroxide)

PKA:

pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)

Henrys Law Constant:

Henry's Law constant = 1.5X10-31 atm-cu m/mol at 25 °C /Estimated/

Dissociation Constants:

4.7|pKa = 4.70 (carboxylic acid)|pKa = 3.5 carboxylic acid; pKa2 = 8.8, pKa3 = 9.2 (amines) /Estimated/

Collision Cross Section:

196.2 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|194.8 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Yellow crystals from dilute hydrogen chloride; decomp 185-204 °C (bath preheated to 160 °C). Max absorption (0.1 n hydrogen chloride): 244, 307 nm; max absorption (0.1 N sodium hydroxide): 257, 302, 370 nm; soluble in alkaline solns with decomposition /Methotrexate monohydrate/|Yellow powder; soluble in water. /Methotrexate sodium/|Hydroxyl radical reaction rate constant = 3.2X10-10 cu cm/molec-sec at 25 °C /Estimated/

Air and Water Reactions:

Methotrexate is sensitive to hydrolysis, oxidation and light. Insoluble in water.

Reactive Group:

Acids, Carboxylic

Reactivity Profile:

Methotrexate decomposes in very acidic or alkaline conditions. Methotrexate is incompatible with strong oxidizing agents and strong acids.

Critical Temperature & Pressure:

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

See More Methotrexate Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Reproductive toxicity, Category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H360 May damage fertility or the unborn child
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P203 Obtain, read and follow all safety instructions before use.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Methotrexate sodium tablets should be protected from light and stored in well-closed containers at 15-30 deg C. Methotrexate sodium injection and powder for injection should be protected from light and stored at 15-30 deg C. Methotrexate sodium

See More Methotrexate Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
CRO

Location:
1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA

Payment Terms:
TT against copy of documents

Average lead Time:
3

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
Above 1000

Year of Establishment:
2006

Company Profile
Founded in 2006, ChemExpress focuses on providing small molecule and new modalities CDMO services for both pharmaceutical and biotech clients. Our comprehensive CRO & CDMO platform is engaged in the research and development, manufacturing and supply of regulatory starting materials, novel building blocks, intermediates, reference compounds, APIs and drug products. We are a one-stop service platform to support our client’s projects from early drug discovery, process development to commercialization.

Over the past 17 years, we have established a state-of-the-art QC/QA system aligning with ICH guidelines for pharmaceutical manufacturing. We provide our clients with high-quality products and CMC services across the entire life-cycle of drug development.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	METHOTREXATE IP/BP/USP	1.00 KG	Jul 4, 2025
India	Methotrexate	1.00 KG	Dec 11, 2023

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