China origin PEGylated lipid ((4-Hydroxybutyl)Azanediyl)Bis(Hexane-6,1-Diyl)Bis(2-Hexyldecanoate) used in non-viral gene delivery systems

Product Name: ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate)

Synonyms: ALC-0315; Lipid ALC-0315; ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl) bis(2-hexyldecanoate); 6-[6-(2-hexyldecanoyloxy)hexyl-(4-hydroxybutyl)amino]hexyl 2-hexyldecanoate; Decanoic acid, 2-hexyl-, 1,1-[[(4-hydroxybutyl)imino]di-6,1-hexanediyl] ester; Decanoic acid, 2-hexyl-, 1,1′-[[(4-hydroxybutyl)imino]di-6,1-hexanediyl] ester

Abbreviation: DHA

CAS No.: 2036272-55-4

Molecular Formula: C48H95NO5

Molecular Weight: 766.272

Brief Introduction:

     Cationic liposome ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), also known as: ALC-0315, is a synthetic cationic lipid (or ionizable lipid). As a PEGylated lipid, it is a colourless oily substance.

     At physiological pH, ALC-0315 is protonated at the nitrogen atom to produce ammonium cations, which are attracted to messenger RNA (mRNA) (messenger RNA is anionic). This property enables cationic liposomes to bind to drugs, genes and other bioactive substances to form positively charged complexes, which help these molecules cross the cell membrane and enter the cell.

Characteristics of ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate):

     ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate) has the ability to self-assemble, making the preparation process relatively simple. At the same time, by forming complexes with negatively charged drugs and binding to cell membranes using electrostatic interactions, these complexes can then enter cells through endocytosis or fusion to achieve effective drug delivery.

     ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate) also has high stability and the ability to protect drugs from enzymatic degradation. Its liposome structure has high stability and can maintain its structural and functional integrity under different environmental conditions. In addition, cationic liposomes can effectively protect negatively charged drugs from enzymatic degradation, thereby improving the bioavailability of drugs.

Applications of ALC-0315:

♔  Gene Delivery:
    ALC-0315 is often used in non-viral gene delivery systems, such as liposome-mediated gene delivery. By binding to DNA or RNA, these lipids can help nucleic acids escape the cell's degradation mechanism and effectively deliver them into the cell.

♔  Biomedical Research:
     In biomedical research, cationic lipids such as ALC-0315 are also widely used in cell culture, gene expression, and protein function research.

Packaging:

1g/Bottle, 3g/Bottle, 5g/Bottle, 10g/Bottle, 100g/Bag or according to the specific requirements from customers.

Recommended Storage Conditions:

     For short-term storage, it is recommended to store at 2℃ ~ 8℃; it is recommended to keep at -25℃ ~ -15℃ under an inert atmosphere for long-term storage.

     For reducing the absorption of the moisture, it should be slowly warmed to ambient temperature before opened.

Shelf Life:

36 months if stored under above mentioned conditions.